ArticleScientific reports2020
Fecal microbiota transplantation from warthog to pig confirms the influence of the gut microbiota on African swine fever susceptibility.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 38 citations in OpenAlex.
- A manually curated pig gut microbiome dataset for precision feeding.Scientific data · 2026Article
- Fecal microbiota transplantation from different pig breeds alters fat deposition and gut microbiota in mice.Applied microbiology and biotechnology · 2026Article
- Metagenomic insights into the global wild boar faecal microbiome reveal novel taxa and carbohydrate degraders distinguishing wild and domesticated Sus.Microbiome · 2026Article
- Unlocking the Black Box: The Molecular Dialogue Between ASFV and Its Tick Host.Pathogens (Basel, Switzerland) · 2026Review
- Innate resistance to African swine fever virus: current knowledge and future directions.BMC veterinary research · 2025Review
- Intestinal microbiota dynamics in piglets: the interplay with swine enteric coronavirus infections and implications for disease control.Animal microbiome · 2025Review
- Fecal microbiota transplantation in pigs: current status and future perspective.Animal microbiome · 2025Review
- Fecal Microbiota Changes in Angus Beef Cows Persistently Infected by Bovine Viral Diarrhea Virus.Veterinary sciences · 2025Article
- Identification ofMicrobiology spectrum · 2025Article
- Spatial prediction of wild boar distribution in Thailand applications for African swine fever prevention and control.Scientific reports · 2025Article
- The impact of wild-boar-derived microbiota transplantation on piglet microbiota, metabolite profile, and gut proinflammatory cytokine production differs from sow-derived microbiota.Applied and environmental microbiology · 2025Article
- Fecal microbiota transplantation modulates jejunal host-microbiota interface in weanling piglets.Microbiome · 2025Article
- InactivatedFrontiers in immunology · 2025Article
- A comparison of wild boar and domestic pig microbiota does not reveal a loss of microbial species but an increase in alpha diversity and opportunistic genera in domestic pigs.Microbiology spectrum · 2024Article
- Identification of Signatures of Positive Selection That Have Shaped the Genomic Landscape of South African Pig Populations.Animals : an open access journal from MDPI · 2024Article
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- Role of genetic factors in different swine breeds exhibiting varying levels of resistance/susceptibility to PRRSV.Virus research · 2023Review
- Cross-protection against African swine fever virus upon intranasal vaccination is associated with an adaptive-innate immune crosstalk.PLoS pathogens · 2022Article
- African Swine Fever Virus pI215L Inhibits Type I Interferon Signaling by Targeting Interferon Regulatory Factor 9 for Autophagic Degradation.Journal of virology · 2022Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
African swine fever virus (ASFV) is the causative agent of a devastating hemorrhagic disease (ASF) that affects both domestic pigs and wild boars. Conversely, ASFV circulates in a subclinical manner in African wild pigs, including warthogs, the natural reservoir for ASFV. Together with genetic differences, other factors might be involved in the differential susceptibility to ASF observed among Eurasian suids (Sus scrofa) and African warthogs (Phacochoerus africanus). Preliminary evidence obtained in our laboratory and others, seems to confirm the effect that environmental factors might have on ASF infection. Thus, domestic pigs raised in specific pathogen-free (SPF) facilities were extremely susceptible to highly attenuated ASFV strains that were innocuous to genetically identical domestic pigs grown on conventional farms. Since gut microbiota plays important roles in maintaining intestinal homeostasis, regulating immune system maturation and the functionality of the innate/adaptive immune responses, we decided to examine whether warthog fecal microbiota transplantation (FMT) to domestic pigs affects host susceptibility to ASFV. The present work demonstrates that warthog FMT is not harmful for domestic weaned piglets, while it modifies their gut microbiota; and that FMT from warthogs to pigs confers partial protection against attenuated ASFV strains. Future work is needed to elucidate the protective mechanisms exerted by warthog FMT.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.