Evidence map›Paper›PMID 33077748›Full record

ArticleScientific reports2020

Force-of-infection of Taenia solium porcine cysticercosis: a modelling analysis to assess global incidence and prevalence trends.

Matthew A Dixon, Peter Winskill, Wendy E Harrison, Charles Whittaker, Veronika Schmidt, Elsa Sarti, Saw Bawm, Michel M Dione, Lian F Thomas, Martin Walker and 1 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 6 countries.

Matthew A DixonDepartment of Infectious Disease Epidemiology and London Centre for Neglected Tropical Disease Research (LCNTDR), Faculty of Medicine, School of Public Health, Imperial College London, London, W2 1PG, UK. m.dixon15@imperial.ac.uk.
Peter WinskillMRC Centre for Global Infectious Disease Analysis, Department of Infectious Disease Epidemiology, Faculty of Medicine, School of Public Health, Imperial College London, London, W2 1PG, UK.
Wendy E HarrisonSCI Foundation, Edinburgh House, 170 Kennington Lane, London, SE11 5DP, UK.
Charles WhittakerMRC Centre for Global Infectious Disease Analysis, Department of Infectious Disease Epidemiology, Faculty of Medicine, School of Public Health, Imperial College London, London, W2 1PG, UK.
Veronika SchmidtDepartment of Neurology, Center for Global Health, Technical University Munich (TUM), Munich, Germany.
Elsa SartiSanofi Pasteur Latin America, Av. Universidad N° 1738, Colonia Coyoacán, 04000, Mexico, D.F., Mexico.
Saw BawmUniversity of Veterinary Science, Yezin, Nay Pyi Taw, 15013, Myanmar.
Michel M DioneInternational Livestock Research Institute, 01 BP 1496, Ouagadougou, Burkina Faso.
Lian F ThomasInternational Livestock Research Institute (ILRI), Old Naivasha Road, PO Box 30709-00100, Nairobi, Kenya.
Martin WalkerDepartment of Pathobiology and Population Sciences and London Centre for Neglected Tropical Disease Research (LCNTDR), Royal Veterinary College, Hatfield, AL9 7TA, UK.
Maria-Gloria BasáñezDepartment of Infectious Disease Epidemiology and London Centre for Neglected Tropical Disease Research (LCNTDR), Faculty of Medicine, School of Public Health, Imperial College London, London, W2 1PG, UK.
Imperial College London · GBInternational Livestock Research Institute · KELondon Centre for Neglected Tropical Disease Research · GBSanofi (Mexico) · MXTechnical University of Munich · DEUniversity of Liverpool · GBUniversity of Veterinary Science · MM

Funding

Biotechnology and Biological Sciences Research Council BB/L019019/1Medical Research Council MR/R015600/1Wellcome Trust
6 · The paper itself

Abstract

The World Health Organization (WHO) called, in 2012, for a validated strategy towards Taenia solium taeniasis/cysticercosis control and elimination. Estimating pig force-of-infection (FoI, the average rate at which susceptible pigs become infected) across geographical settings will help understand local epidemiology and inform effective intervention design. Porcine cysticercosis (PCC) age-prevalence data (from 15 studies in Latin America, Africa and Asia) were identified through systematic review. Catalytic models were fitted to the data using Bayesian methods, incorporating uncertainty in diagnostic performance, to estimate rates of antibody seroconversion, viable metacestode acquisition, and seroreversion/infection loss. There was evidence of antibody seroreversion across 5 studies, and of infection loss in 6 studies measured by antigen or necropsy, indicating transient serological responses and natural resolution of infection. Concerted efforts should be made to collect robust data using improved diagnostics to better understand geographical heterogeneities in T. solium transmission to support post-2020 WHO targets.

Indexed as

Models, TheoreticalAnimalsCysticercosisIncidencePrevalenceSwineSwine DiseasesTaenia solium

Identifiers

PMID33077748
PMCPMC7572398
OpenAlexW3093254777

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.