Evidence map›Paper›PMID 33077699›Full record

ArticleBiomolecules & therapeutics2021

Antaroide, a Novel Natural Nine-Membered Macrolide, Inhibits Melanin Biosynthesis in B16F10 Murine Melanoma Cells.

Min-Ji Ryu, Eun-Ki Baek, Soyeon Kim, Chi Nam Seong, Inho Yang, Kyung-Min Lim, Sang-Jip Nam

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules & therapeutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Evidence-based complementary and alternative medicine : eCAM · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Min-Ji RyuDepartment of Chemistry and Nanoscience, Ewha Womans University, Seoul 03760, Republic of Korea.
Eun-Ki BaekCollege of Pharmacy, Ewha Womans University, Seoul 03760, Republic of Korea.
Soyeon KimCollege of Pharmacy, Ewha Womans University, Seoul 03760, Republic of Korea.
Chi Nam SeongDepartment of Biology, College of Life Science and Natural Resource, Sunchon National University, Suncheon 57922, Republic of Korea.
Inho YangDepartment of Convergence Study on the Ocean Science and Technology, Korea Maritime and Ocean University, Busan 49112, Republic of Korea.
Kyung-Min LimCollege of Pharmacy, Ewha Womans University, Seoul 03760, Republic of Korea.
Sang-Jip NamDepartment of Chemistry and Nanoscience, Ewha Womans University, Seoul 03760, Republic of Korea.
Ewha Womans University · KRKorea Maritime and Ocean University · KRSunchon National University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

1: ). The chemical structure was established through the interpretation of MS, UV, and NMR spectroscopic data. Antaroide is a nine-membered macrolide with lactone and lactam moieties. To investigate its applicability in skin whitening cosmetics, its anti-melanogenic activity in B16F10 murine melanoma cells was examined. As a result, antaroide displayed strong inhibitory activities against melanin synthesis and also attenuated the dendrite formation induced by the α-melanocyte stimulating hormone (α-MSH). Antaroide suppressed the mRNA expression of the melanogenic enzymes such as tyrosinase, TRP-1 and TRP-2. This suggests that it may serve as a transcriptional regulator of melanogenesis. Collectively, the discovery of this novel natural nine-membered macrolide and its anti-melanogenic activity could give new insights for the development of skin whitening agents.

Indexed as

Marine natural productMelanin synthesis inhibitorNine-membered macrolideSkin whitening agentStreptomyces sp.

Identifiers

PMID33077699
PMCPMC7771842
OpenAlexW3092858052

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.