Evidence map›Paper›PMID 33077659›Full record

ArticleAntimicrobial agents and chemotherapy2020

Optimization of a Noncanonical Anti-infective: Interrogation of the Target Binding Pocket for a Small-Molecule Inhibitor of Escherichia coli Polysaccharide Capsule Expression.

Mehreen Arshad, Grace A Beggs, Richard G Brennan, Patrick C Seed

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 62% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Mehreen Arshad *Department of Pediatrics, Duke University School of Medicine, Durham, North Carolina, USA marshad@luriechildrens.org.ORCID 0000-0002-7517-9274
Grace A Beggs *Department of Biochemistry, Duke University School of Medicine, Durham, North Carolina, USA.ORCID 0000-0003-3537-913X
Richard G BrennanDepartment of Biochemistry, Duke University School of Medicine, Durham, North Carolina, USA.ORCID 0000-0001-7647-485X
Patrick C SeedDepartment of Pediatrics, Duke University School of Medicine, Durham, North Carolina, USA.
Duke University · US

Funding

Center for Molecular &Cellular Studies of Ped DiseaseK12HD043494 · NICHD · DUKE UNIVERSITY · PI REED, ANN M. · 2003 to 2017
$5.2M
Investigating a Novel Co-regulation of Multi-Drug Efflux Pumps and Polysaccharide Capsule in E. coliK08AI123524 · NIAID · LURIE CHILDREN'S HOSPITAL OF CHICAGO · PI ARSHAD, MEHREEN · 2017 to 2021
$942k
NIAID NIH HHS K08 AI123524NICHD NIH HHS K12 HD043494
6 · The paper itself

Abstract

We previously identified a small-molecule inhibitor of capsule biogenesis (designated DU011) and identified its target as MprA, a MarR family transcriptional repressor of multidrug efflux pumps. Unlike other proposed MprA ligands, such as salicylate and 2,4-dinitrophenol (DNP), DU011 does not alter

Indexed as

Escherichia coliEscherichia coli ProteinsAnti-Bacterial AgentsBinding SitesDrug Resistance, MicrobialLigandsPolysaccharidesProtein BindingAnti-Bacterial AgentsEscherichia coli ProteinsLigandsPolysaccharidesEscherichia coliisothermal titration calorimetryMarR familysmall-molecule inhibitor

Identifiers

PMID33077659
PMCPMC7927849
OpenAlexW3093123238

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.