Evidence map›Paper›PMID 33077643›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2020

Evaluation of IL-17D in Host Immunity to Group A

Allen Washington, Nissi Varki, J Andrés Valderrama, Victor Nizet, Jack D Bui

Open access · bronzeAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Allen WashingtonDepartment of Pathology, University of California, San Diego, La Jolla, CA 92093.
Nissi VarkiDepartment of Pathology, University of California, San Diego, La Jolla, CA 92093.ORCID 0000-0001-9839-1254
J Andrés ValderramaDepartment of Pediatrics, University of California, San Diego, La Jolla, CA 92161; and.
Victor NizetDepartment of Pediatrics, University of California, San Diego, La Jolla, CA 92161; and.ORCID 0000-0003-3847-0422
Jack D BuiDepartment of Pathology, University of California, San Diego, La Jolla, CA 92093; jbui@ucsd.edu.ORCID 0000-0002-9324-368X
University of California San Diego · US

Funding

Innate anti-tumor immune responsesR01CA157885 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BUI, JACK D · 2011 to 2015
$1.8M
Elucidating the regulation and function of IL-17D using reporter miceR21AI149023 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BUI, JACK D · 2020 to 2021
$434k
NCI NIH HHS R01 CA157885NIAID NIH HHS R21 AI149023
6 · The paper itself

Abstract

IL-17D is a cytokine that belongs to the IL-17 family and is conserved in vertebrates and invertebrates. In contrast to IL-17A and IL-17F, which are expressed in Th17 cells, IL-17D is expressed broadly in nonimmune cells. IL-17D can promote immune responses to cancer and viruses in part by inducing chemokines and recruiting innate immune cells such as NK cells. Although bacterial infection can induce IL-17D in fish and invertebrates, the role of mammalian IL-17D in antibacterial immunity has not been established. To determine whether IL-17D has a role in mediating host defense against bacterial infections, we studied i.p. infection by group A

Indexed as

AnimalsChemokine CCL2Immunity, InnateInterleukin-27Killer Cells, NaturalMiceMice, Inbred C57BLNeutrophilsPathogen-Associated Molecular Pattern MoleculesStreptococcal InfectionsStreptococcusTh17 CellsChemokine CCL2Interleukin-27Pathogen-Associated Molecular Pattern Molecules

Identifiers

PMID33077643
PMCPMC7686091
OpenAlexW3093378004

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.