Evidence map›Paper›PMID 33077625›Full record

ArticleInfection and immunity2020

Silencing of Ac45 Simultaneously Inhibits Osteoclast-Mediated Bone Resorption and Attenuates Dendritic Cell-Mediated Inflammation through Impairing Acidification and Cathepsin K Secretion.

Wenbin Yang, Zheng Zhu, Longjiang Li, Abigail McVicar, Ning Gao, Lin Wang, Yi-Ping Li, Wei Chen

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Infection and immunity, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Review
  6. Exploring the role of cathepsin in rheumatoid arthritis.Saudi journal of biological sciences · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Wenbin Yang *Department of Pathology, The School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Zheng Zhu *Department of Pathology, The School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Longjiang LiState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Sichuan, People's Republic of China.
Abigail McVicarDepartment of Pathology, The School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Ning GaoDepartment of Pathology, The School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Lin WangCollege of Stomatology, Nanjing Medical University, Nanjing, People's Republic of China.
Yi-Ping LiDepartment of Pathology, The School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA yipingli@uabmc.edu weichen@uabmc.edu.
Wei ChenDepartment of Pathology, The School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA yipingli@uabmc.edu weichen@uabmc.edu.ORCID 0000-0003-2143-0117
University of Alabama at Birmingham · USSichuan University · CNNanjing Medical University · CN

Funding

Inhibiting Periodontitis by Targeting Cathepsin K and Attenuating TLR SignalingR01DE023813 · NIDCR · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI LI, YI-PING · 2014 to 2023
$3.9M
Mechanistic basis of the role of Cbx3 in negatively regulating osteoclast differentiation through epigenetic modificationR01AR075735 · NIAMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI LI, YI-PING · 2019 to 2024
$2.4M
Cbfβ mediates articular cartilage regeneration and repair in agingR01AG056438 · NIA · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CHEN, WEI · 2019 to 2023
$2.1M
Gα13 signaling attenuates periodontal inflammation and alveolar bone loss in the mouse model of age-associated periodontitisR01DE028264 · NIDCR · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI LI, YI-PING · 2018 to 2022
$1.8M
Characterizing the negative signaling in dendritic cells and macrophages to attenuate inflammation and bone destruction in Rheumatoid arthritisR01AR074954 · NIAMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI LI, YI-PING · 2020 to 2024
$1.6M
Characterizing the mechanism by which endogenous negative regulators of osteoclasts control bone homeostasis under physiological and pathological conditions in mouse modelsR01AR070135 · NIAMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CHEN, WEI · 2017 to 2021
$1.6M
Cbfβ mediates articular cartilage regeneration and repair in agingR56AG056438 · NIA · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CHEN, WEI · 2017 to 2017
$371k
NIAMS NIH HHS R01 AR070135NIAMS NIH HHS R01 AR074954NIAMS NIH HHS R01 AR075735NIA NIH HHS R01 AG056438NIA NIH HHS R56 AG056438NIDCR NIH HHS R01 DE023813NIDCR NIH HHS R01 DE028264
6 · The paper itself

Abstract

Endodontic disease is characterized by inflammation and destruction of periapical tissues, leading to severe bone resorption and tooth loss. ATP6AP1 (Ac45) has been implicated in human immune diseases, yet the mechanism underlying how Ac45 regulates immune response and reaction in inflammatory diseases remains unknown. We generated endodontic disease mice through bacterial infection as an inflammatory disease model and used adeno-associated virus (AAV)-mediated

Indexed as

Gene SilencingAlveolar Bone LossAnimalsBone ResorptionCathepsin KCell CountCytokinesDendritic CellsDependovirusDisease Models, AnimalGene Knockdown TechniquesHydrogen-Ion ConcentrationInflammationMiceOsteoclastsRNA InterferenceAtp6ap1 protein, mouseCathepsin KCytokinesVacuolar Proton-Translocating ATPasesAc45adeno-associated virusbone resorptionendodontic diseaseinflammationRNAi silencing

Identifiers

PMID33077625
PMCPMC7927931
OpenAlexW3093345462

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.