Evidence map›Paper›PMID 33077621›Full record

ArticleInfection and immunity2020

GigC, a LysR Family Transcription Regulator, Is Required for Cysteine Metabolism and Virulence in Acinetobacter baumannii.

Michael J Gebhardt, Daniel M Czyz, Shweta Singh, Daniel V Zurawski, Lev Becker, Howard A Shuman

Abstract read
In one paragraph

Article in Infection and immunity, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. ISmLife · 2026
    Article
  2. Article
  3. Article
  4. Arginine utilization inInfection and immunity · 2025
    Article
  5. Recent advances in host models in studying virulence factors and pathogenesis ofFrontiers in cellular and infection microbiology · 2025
    Review
  6. Review
  7. Article
  8. Article
  9. Virulence Factors and Pathogenicity Mechanisms ofAntibiotics (Basel, Switzerland) · 2023
    Review
  10. Review
  11. Review
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Michael J GebhardtDivision of Infectious Diseases, Boston Children's Hospital, Boston, Massachusetts, USA michael.gebhardt@childrens.harvard.edu.ORCID 0000-0002-1213-8408
Daniel M CzyzDepartment of Microbiology and Cell Science, University of Florida, Gainesville, Florida, USA.ORCID 0000-0002-7491-5292
Shweta SinghWound Infections Dept., Bacterial Diseases Branch, Center for Infectious Diseases Research, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.
Daniel V ZurawskiWound Infections Dept., Bacterial Diseases Branch, Center for Infectious Diseases Research, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.ORCID 0000-0002-7920-5601
Lev BeckerBen May Department of Cancer Research, University of Chicago, Chicago, Illinois, USA.ORCID 0000-0002-9663-8038
Howard A ShumanDepartment of Microbiology, University of Chicago, Chicago, Illinois, USA.ORCID 0000-0001-7955-8709

Funding

Regulation of stress resistance and virulence genes in Acinetobacter baumanniiR21AI115203 · NIAID · UNIVERSITY OF CHICAGO · PI SHUMAN, HOWARD A · 2015 to 2016
$423k
NIAID NIH HHS R21 AI115203
6 · The paper itself

Abstract

A critical facet of mammalian innate immunity involves the hosts' attempts to sequester and/or limit the availability of key metabolic products from pathogens. For example, nutritional immunity encompasses host approaches to limit the availability of key heavy metal ions such as zinc and iron. Previously, we identified several hundred genes in a multidrug-resistant isolate of

Indexed as

Acinetobacter baumanniiAcinetobacter InfectionsAnimalsCysteineDisease Models, AnimalEnergy MetabolismGene Expression Regulation, BacterialMiceMultigene FamilyProtein BindingProtein MultimerizationTranscription FactorsVirulenceVirulence FactorsCysteineTranscription FactorsVirulence FactorsAcinetobacter baumanniicysteinetranscription factors

Identifiers

PMID33077621
PMCPMC7927930

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.