ArticleNeurology2020
Derivation and utility of an Aβ-PET pathology accumulation index to estimate Aβ load.
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Article in Neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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11citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
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Who cites it
11 citing papers in PubMed, 17 citations in OpenAlex.
- AI-enhanced Centiloid quantification of amyloid PET images.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Revisiting Centiloids using AI.Research square · 2025Article
- A new method for community-based intelligent screening of early Alzheimer's disease populations based on digital biomarkers of the writing process.Frontiers in computational neuroscience · 2025Article
- Validation of quantitative assessment of florbetaben PET scans as an adjunct to the visual assessment across 15 software methods.European journal of nuclear medicine and molecular imaging · 2023Article
- CSF 14-3-3β is associated with progressive cognitive decline in Alzheimer's disease.Brain communications · 2023Article
- β-amyloid PET harmonisation across longitudinal studies: Application to AIBL, ADNI and OASIS3.NeuroImage · 2022Article
- Quantification of amyloid PET for future clinical use: a state-of-the-art review.European journal of nuclear medicine and molecular imaging · 2022Review
- The Use, Standardization, and Interpretation of Brain Imaging Data in Clinical Trials of Neurodegenerative Disorders.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2021Review
- Alzheimer's disease heterogeneity revealed by neuroanatomical normative modeling.Alzheimer's & dementia (Amsterdam, Netherlands)Article
- Quantification of global gray matter amyloid-β plaque fromAlzheimer's & dementia (Amsterdam, Netherlands)Article
- A universal neocortical mask for Centiloid quantification.Alzheimer's & dementia (Amsterdam, Netherlands)Article
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Authors and funding
13 authors at 1 institution in 4 countries.
Antoine LeuzyFrom the Clinical Memory Research Unit (A.L., J.L., R.O., S.P., S.J., E.S., O.S., R.S., O.H.), Department of Clinical Sciences, Lund University, Malmö; Department of Surgical Sciences, Nuclear Medicine and PET (J.L.), Uppsala University; Hermes Medical Solutions (J.L.), Stockholm, Sweden; GE Healthcare Life Sciences (C.J.B., M.B., G.F.), Amersham, UK; VU University Medical Center (R.O.), Neuroscience Campus Amsterdam, the Netherlands; Department of Neurology (S.P., R.S.) and Memory Clinic (E.S., O.H.), Skåne University Hospital, Lund, Sweden; Department of Imaging and Pathology (D.R.T.), Laboratory of Neuropathology, and Leuven Brain Institute (D.R.T.), Campus Gasthuisberg; and Department of Pathology (D.R.T.), UZ-Leuven, Belgium. antoine.leuzy@med.lu.se.
Johan LiljaFrom the Clinical Memory Research Unit (A.L., J.L., R.O., S.P., S.J., E.S., O.S., R.S., O.H.), Department of Clinical Sciences, Lund University, Malmö; Department of Surgical Sciences, Nuclear Medicine and PET (J.L.), Uppsala University; Hermes Medical Solutions (J.L.), Stockholm, Sweden; GE Healthcare Life Sciences (C.J.B., M.B., G.F.), Amersham, UK; VU University Medical Center (R.O.), Neuroscience Campus Amsterdam, the Netherlands; Department of Neurology (S.P., R.S.) and Memory Clinic (E.S., O.H.), Skåne University Hospital, Lund, Sweden; Department of Imaging and Pathology (D.R.T.), Laboratory of Neuropathology, and Leuven Brain Institute (D.R.T.), Campus Gasthuisberg; and Department of Pathology (D.R.T.), UZ-Leuven, Belgium.ORCID 0000-0002-9752-6142
Christopher J BuckleyFrom the Clinical Memory Research Unit (A.L., J.L., R.O., S.P., S.J., E.S., O.S., R.S., O.H.), Department of Clinical Sciences, Lund University, Malmö; Department of Surgical Sciences, Nuclear Medicine and PET (J.L.), Uppsala University; Hermes Medical Solutions (J.L.), Stockholm, Sweden; GE Healthcare Life Sciences (C.J.B., M.B., G.F.), Amersham, UK; VU University Medical Center (R.O.), Neuroscience Campus Amsterdam, the Netherlands; Department of Neurology (S.P., R.S.) and Memory Clinic (E.S., O.H.), Skåne University Hospital, Lund, Sweden; Department of Imaging and Pathology (D.R.T.), Laboratory of Neuropathology, and Leuven Brain Institute (D.R.T.), Campus Gasthuisberg; and Department of Pathology (D.R.T.), UZ-Leuven, Belgium.
Rik OssenkoppeleFrom the Clinical Memory Research Unit (A.L., J.L., R.O., S.P., S.J., E.S., O.S., R.S., O.H.), Department of Clinical Sciences, Lund University, Malmö; Department of Surgical Sciences, Nuclear Medicine and PET (J.L.), Uppsala University; Hermes Medical Solutions (J.L.), Stockholm, Sweden; GE Healthcare Life Sciences (C.J.B., M.B., G.F.), Amersham, UK; VU University Medical Center (R.O.), Neuroscience Campus Amsterdam, the Netherlands; Department of Neurology (S.P., R.S.) and Memory Clinic (E.S., O.H.), Skåne University Hospital, Lund, Sweden; Department of Imaging and Pathology (D.R.T.), Laboratory of Neuropathology, and Leuven Brain Institute (D.R.T.), Campus Gasthuisberg; and Department of Pathology (D.R.T.), UZ-Leuven, Belgium.
Sebastian PalmqvistFrom the Clinical Memory Research Unit (A.L., J.L., R.O., S.P., S.J., E.S., O.S., R.S., O.H.), Department of Clinical Sciences, Lund University, Malmö; Department of Surgical Sciences, Nuclear Medicine and PET (J.L.), Uppsala University; Hermes Medical Solutions (J.L.), Stockholm, Sweden; GE Healthcare Life Sciences (C.J.B., M.B., G.F.), Amersham, UK; VU University Medical Center (R.O.), Neuroscience Campus Amsterdam, the Netherlands; Department of Neurology (S.P., R.S.) and Memory Clinic (E.S., O.H.), Skåne University Hospital, Lund, Sweden; Department of Imaging and Pathology (D.R.T.), Laboratory of Neuropathology, and Leuven Brain Institute (D.R.T.), Campus Gasthuisberg; and Department of Pathology (D.R.T.), UZ-Leuven, Belgium.
Mark BattleFrom the Clinical Memory Research Unit (A.L., J.L., R.O., S.P., S.J., E.S., O.S., R.S., O.H.), Department of Clinical Sciences, Lund University, Malmö; Department of Surgical Sciences, Nuclear Medicine and PET (J.L.), Uppsala University; Hermes Medical Solutions (J.L.), Stockholm, Sweden; GE Healthcare Life Sciences (C.J.B., M.B., G.F.), Amersham, UK; VU University Medical Center (R.O.), Neuroscience Campus Amsterdam, the Netherlands; Department of Neurology (S.P., R.S.) and Memory Clinic (E.S., O.H.), Skåne University Hospital, Lund, Sweden; Department of Imaging and Pathology (D.R.T.), Laboratory of Neuropathology, and Leuven Brain Institute (D.R.T.), Campus Gasthuisberg; and Department of Pathology (D.R.T.), UZ-Leuven, Belgium.
Gill FarrarFrom the Clinical Memory Research Unit (A.L., J.L., R.O., S.P., S.J., E.S., O.S., R.S., O.H.), Department of Clinical Sciences, Lund University, Malmö; Department of Surgical Sciences, Nuclear Medicine and PET (J.L.), Uppsala University; Hermes Medical Solutions (J.L.), Stockholm, Sweden; GE Healthcare Life Sciences (C.J.B., M.B., G.F.), Amersham, UK; VU University Medical Center (R.O.), Neuroscience Campus Amsterdam, the Netherlands; Department of Neurology (S.P., R.S.) and Memory Clinic (E.S., O.H.), Skåne University Hospital, Lund, Sweden; Department of Imaging and Pathology (D.R.T.), Laboratory of Neuropathology, and Leuven Brain Institute (D.R.T.), Campus Gasthuisberg; and Department of Pathology (D.R.T.), UZ-Leuven, Belgium.
Dietmar R ThalFrom the Clinical Memory Research Unit (A.L., J.L., R.O., S.P., S.J., E.S., O.S., R.S., O.H.), Department of Clinical Sciences, Lund University, Malmö; Department of Surgical Sciences, Nuclear Medicine and PET (J.L.), Uppsala University; Hermes Medical Solutions (J.L.), Stockholm, Sweden; GE Healthcare Life Sciences (C.J.B., M.B., G.F.), Amersham, UK; VU University Medical Center (R.O.), Neuroscience Campus Amsterdam, the Netherlands; Department of Neurology (S.P., R.S.) and Memory Clinic (E.S., O.H.), Skåne University Hospital, Lund, Sweden; Department of Imaging and Pathology (D.R.T.), Laboratory of Neuropathology, and Leuven Brain Institute (D.R.T.), Campus Gasthuisberg; and Department of Pathology (D.R.T.), UZ-Leuven, Belgium.ORCID 0000-0002-1036-1075
Shorena JanelidzeFrom the Clinical Memory Research Unit (A.L., J.L., R.O., S.P., S.J., E.S., O.S., R.S., O.H.), Department of Clinical Sciences, Lund University, Malmö; Department of Surgical Sciences, Nuclear Medicine and PET (J.L.), Uppsala University; Hermes Medical Solutions (J.L.), Stockholm, Sweden; GE Healthcare Life Sciences (C.J.B., M.B., G.F.), Amersham, UK; VU University Medical Center (R.O.), Neuroscience Campus Amsterdam, the Netherlands; Department of Neurology (S.P., R.S.) and Memory Clinic (E.S., O.H.), Skåne University Hospital, Lund, Sweden; Department of Imaging and Pathology (D.R.T.), Laboratory of Neuropathology, and Leuven Brain Institute (D.R.T.), Campus Gasthuisberg; and Department of Pathology (D.R.T.), UZ-Leuven, Belgium.
Erik StomrudFrom the Clinical Memory Research Unit (A.L., J.L., R.O., S.P., S.J., E.S., O.S., R.S., O.H.), Department of Clinical Sciences, Lund University, Malmö; Department of Surgical Sciences, Nuclear Medicine and PET (J.L.), Uppsala University; Hermes Medical Solutions (J.L.), Stockholm, Sweden; GE Healthcare Life Sciences (C.J.B., M.B., G.F.), Amersham, UK; VU University Medical Center (R.O.), Neuroscience Campus Amsterdam, the Netherlands; Department of Neurology (S.P., R.S.) and Memory Clinic (E.S., O.H.), Skåne University Hospital, Lund, Sweden; Department of Imaging and Pathology (D.R.T.), Laboratory of Neuropathology, and Leuven Brain Institute (D.R.T.), Campus Gasthuisberg; and Department of Pathology (D.R.T.), UZ-Leuven, Belgium.
Olof StrandbergFrom the Clinical Memory Research Unit (A.L., J.L., R.O., S.P., S.J., E.S., O.S., R.S., O.H.), Department of Clinical Sciences, Lund University, Malmö; Department of Surgical Sciences, Nuclear Medicine and PET (J.L.), Uppsala University; Hermes Medical Solutions (J.L.), Stockholm, Sweden; GE Healthcare Life Sciences (C.J.B., M.B., G.F.), Amersham, UK; VU University Medical Center (R.O.), Neuroscience Campus Amsterdam, the Netherlands; Department of Neurology (S.P., R.S.) and Memory Clinic (E.S., O.H.), Skåne University Hospital, Lund, Sweden; Department of Imaging and Pathology (D.R.T.), Laboratory of Neuropathology, and Leuven Brain Institute (D.R.T.), Campus Gasthuisberg; and Department of Pathology (D.R.T.), UZ-Leuven, Belgium.
Ruben SmithFrom the Clinical Memory Research Unit (A.L., J.L., R.O., S.P., S.J., E.S., O.S., R.S., O.H.), Department of Clinical Sciences, Lund University, Malmö; Department of Surgical Sciences, Nuclear Medicine and PET (J.L.), Uppsala University; Hermes Medical Solutions (J.L.), Stockholm, Sweden; GE Healthcare Life Sciences (C.J.B., M.B., G.F.), Amersham, UK; VU University Medical Center (R.O.), Neuroscience Campus Amsterdam, the Netherlands; Department of Neurology (S.P., R.S.) and Memory Clinic (E.S., O.H.), Skåne University Hospital, Lund, Sweden; Department of Imaging and Pathology (D.R.T.), Laboratory of Neuropathology, and Leuven Brain Institute (D.R.T.), Campus Gasthuisberg; and Department of Pathology (D.R.T.), UZ-Leuven, Belgium.
Oskar HanssonFrom the Clinical Memory Research Unit (A.L., J.L., R.O., S.P., S.J., E.S., O.S., R.S., O.H.), Department of Clinical Sciences, Lund University, Malmö; Department of Surgical Sciences, Nuclear Medicine and PET (J.L.), Uppsala University; Hermes Medical Solutions (J.L.), Stockholm, Sweden; GE Healthcare Life Sciences (C.J.B., M.B., G.F.), Amersham, UK; VU University Medical Center (R.O.), Neuroscience Campus Amsterdam, the Netherlands; Department of Neurology (S.P., R.S.) and Memory Clinic (E.S., O.H.), Skåne University Hospital, Lund, Sweden; Department of Imaging and Pathology (D.R.T.), Laboratory of Neuropathology, and Leuven Brain Institute (D.R.T.), Campus Gasthuisberg; and Department of Pathology (D.R.T.), UZ-Leuven, Belgium.
Uppsala University · SE
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate a novel β-amyloid (Aβ)-PET-based quantitative measure (Aβ accumulation index [Aβ index]), including the assessment of its ability to discriminate between participants based on Aβ status using visual read, CSF Aβ
methodsOne thousand one hundred twenty-one participants (with and without cognitive impairment) were scanned with Aβ-PET: Swedish BioFINDER, n = 392, [
resultsStrong associations were observed between Aβ index and SUVR (
conclusionThe proposed Aβ index showed a tight association to SUVR and carries an advantage over the latter in that it does not require the definition of regions of interest or the use of MRI. Aβ index may thus prove simpler to implement in clinical settings and may also facilitate the comparison of findings using different Aβ-PET tracers. CLASSIFICATION OF EVIDENCE: This study provides Class III evidence that the Aβ accumulation index accurately differentiates Aβ-positive from Aβ-negative participants compared to Aβ-PET visual reads, CSF Aβ
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Alzheimer DiseaseAmyloid beta-PeptidesAniline CompoundsBenzothiazolesBrainCognitive DysfunctionHumansMagnetic Resonance ImagingPlaque, AmyloidPositron-Emission TomographyRadiopharmaceuticalsAmyloid beta-PeptidesAniline CompoundsBenzothiazolesflutemetamolRadiopharmaceuticals
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