Evidence map›Paper›PMID 33077513›Full record

ArticleJournal for immunotherapy of cancer2020

The Society for Immunotherapy of Cancer (SITC) clinical practice guideline on immunotherapy for the treatment of acute leukemia.

Michael M Boyiadzis, Ivan Aksentijevich, Daniel A Arber, John Barrett, Renier J Brentjens, Jill Brufsky, Jorge Cortes, Marcos De Lima, Stephen J Forman, Ephraim J Fuchs and 7 more

Open access · goldAbstract read
In one paragraph

Article in Journal for immunotherapy of cancer, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Guideline
  2. Review
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 15 institutions in 2 countries.

Michael M BoyiadzisDepartment of Medicine, UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA boyiadzism@upmc.edu.
Ivan AksentijevichVirginia Cancer Specialists, Fairfax, Virginia, USA.
Daniel A ArberDepartment of Pathology, University of Chicago, Chicago, Illinois, USA.
John BarrettStem Cell Allotransplantation Section, Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA.
Renier J BrentjensDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Jill BrufskyDepartment of Medicine, UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Jorge CortesDepartment of Medicine, Division of Hematology/Oncology, Georgia Cancer Center, Augusta, Georgia, USA.
Marcos De LimaDivision of Hematology, University Hospitals of Cleveland and Case Western Reserve University, Cleveland, Ohio, USA.
Stephen J FormanHematologic Malignancies Research Institute, City of Hope National Medical Center, Duarte, California, USA.
Ephraim J FuchsSidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Linda J FukasClinical Research Services, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
Steven D GoreInvestigational Drug Branch, Cancer Therapy Evaluation Program, National Cancer Institute, Bethesda, Maryland, USA.
Mark R LitzowDivision of Hematology, Mayo Clinic, Rochester, Minnesota, USA.
Jeffrey S MillerDivision of Hematology, Oncology and Transplantation, Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA.
John M PagelCenter for Blood Disorders and Stem Cell Transplantation, Swedish Cancer Institute, Seattle, Washington, USA.
Edmund K WallerDepartment of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, Georgia, USA.
Martin S TallmanDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Memorial Sloan Kettering Cancer Center · USUPMC Hillman Cancer Center · USCity Of Hope National Medical Center · USEmory University · USMayo Clinic · USNational Cancer Center of Georgia · GENational Cancer Institute · USNational Institutes of Health · USSidney Kimmel Comprehensive Cancer Center · USSwedish Medical Center · USUniversity Hospitals of Cleveland · USUniversity of Chicago · USUniversity of Minnesota Medical Center · USUniversity of Pittsburgh Medical Center · USVirginia Cancer Specialists · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
NCATS NIH HHS UL1 TR001863
6 · The paper itself

Abstract

Acute leukemia is a constellation of rapidly progressing diseases that affect a wide range of patients regardless of age or gender. Traditional treatment options for patients with acute leukemia include chemotherapy and hematopoietic cell transplantation. The advent of cancer immunotherapy has had a significant impact on acute leukemia treatment. Novel immunotherapeutic agents including antibody-drug conjugates, bispecific T cell engagers, and chimeric antigen receptor T cell therapies have efficacy and have recently been approved by the US Food and Drug Administration (FDA) for the treatment of patients with acute leukemia. The Society for Immunotherapy of Cancer (SITC) convened a panel of experts to develop a clinical practice guideline composed of consensus recommendations on immunotherapy for the treatment of acute lymphoblastic leukemia and acute myeloid leukemia.

Indexed as

Guidelines as TopicHumansImmunotherapyLeukemia, Myeloid, AcuteMaleantineoplastic protocolschimeric antigenguidelines as topichematological neoplasmsimmunotherapyreceptors

Identifiers

PMID33077513
PMCPMC7574947
OpenAlexW3093301124

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.