Evidence map›Paper›PMID 33077489›Full record

ArticleGenetics2020

Hmx3a Has Essential Functions in Zebrafish Spinal Cord, Ear and Lateral Line Development.

Samantha J England, Gustavo A Cerda, Angelica Kowalchuk, Taylor Sorice, Ginny Grieb, Katharine E Lewis

Open access · hybridAbstract read
In one paragraph

Article in Genetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Samantha J EnglandDepartment of Biology, Syracuse University, New York 13244.ORCID 0000-0002-0566-643X
Gustavo A CerdaDepartment of Physiology, Development and Neuroscience, University of Cambridge, CB2 3DY, UK.
Angelica KowalchukDepartment of Biology, Syracuse University, New York 13244.ORCID 0000-0003-1331-2321
Taylor SoriceDepartment of Biology, Syracuse University, New York 13244.ORCID 0000-0003-2261-7426
Ginny GriebDepartment of Biology, Syracuse University, New York 13244.ORCID 0000-0002-3358-2081
Katharine E LewisDepartment of Biology, Syracuse University, New York 13244 kelewi02@syr.edu.ORCID 0000-0002-3934-2281
Syracuse University · USUniversity of Cambridge · GB

Funding

Specification of Functional Characteristics of Spinal Cord InterneuronsR01NS077947 · NINDS · SYRACUSE UNIVERSITY · PI LEWIS, KATHARINE EMMA · 2014 to 2019
$1.6M
NINDS NIH HHS R01 NS077947
6 · The paper itself

Abstract

Transcription factors that contain a homeodomain DNA-binding domain have crucial functions in most aspects of cellular function and embryonic development in both animals and plants. Hmx proteins are a subfamily of NK homeodomain-containing proteins that have fundamental roles in development of sensory structures such as the eye and the ear. However, Hmx functions in spinal cord development have not been analyzed. Here, we show that zebrafish (

Indexed as

AnimalsBinding SitesEar, InnerInterneuronsLateral Line SystemNeurogenesisSpinal CordTranscription FactorsZebrafishZebrafish Proteinshmx3a protein, zebrafishTranscription FactorsZebrafish ProteinsdI2genetic compensationHmx2interneuronmorpholino

Identifiers

PMID33077489
PMCPMC7768253
OpenAlexW3092707381

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.