Evidence map›Paper›PMID 33077405›Full record

ReviewSeminars in cell & developmental biology2021

RNA processing in neurological tissue: development, aging and disease.

Ryan A Szeto, Timothy Tran, Justin Truong, Priscilla D Negraes, Cleber A Trujillo

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Seminars in cell & developmental biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. MicroRNA-1: Diverse role of a small player in multiple cancers.Seminars in cell & developmental biology · 2022
    Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Ryan A SzetoDepartment of Pediatrics, School of Medicine, University of California San Diego, La Jolla, CA 92037, USA.
Timothy TranDepartment of Pediatrics, School of Medicine, University of California San Diego, La Jolla, CA 92037, USA.
Justin TruongDepartment of Pediatrics, School of Medicine, University of California San Diego, La Jolla, CA 92037, USA.
Priscilla D NegraesDepartment of Pediatrics, School of Medicine, University of California San Diego, La Jolla, CA 92037, USA.
Cleber A TrujilloDepartment of Pediatrics, School of Medicine, University of California San Diego, La Jolla, CA 92037, USA. Electronic address: ctrujillo@ucsd.edu.
University of California, San Diego · US

Funding

A human neurodevelopmental model of Fetal Alcohol Spectrum DisordersK01AA026911 · NIAAA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI TRUJILLO, CLEBER A · 2019 to 2020
$289k
NIAAA NIH HHS K01 AA026911
6 · The paper itself

Abstract

Gene expression comprises a diverse array of enzymes, proteins, non-coding transcripts, and cellular structures to guide the transfer of genetic information to its various final products. In the brain, the coordination among genes, or lack thereof, characterizes individual brain regions, mediates a variety of brain-related disorders, and brings light to fundamental differences between species. RNA processing, occurring between transcription and translation, controls an essential portion of gene expression through splicing, editing, localization, stability, and interference. The machinery to regulate transcripts must operate with precision serving as a blueprint for proteins and non-coding RNAs to derive their identity. Therefore, RNA processing has a broad scope of influence in the brain, as it modulates cell morphogenesis during development and underlies mechanisms behind certain neurological diseases. Here, we present these ideas through recent findings on RNA processing in development and post-developmental maturity to advance therapeutic discoveries and the collective knowledge of the RNA life cycle.

Indexed as

AgingGene ExpressionHumansNervous System DiseasesRNA Processing, Post-TranscriptionalBrain developmentNeurological disorderRNA processingTherapy

Identifiers

PMID33077405
PMCPMC8050165
OpenAlexW3093278508

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.