Evidence map›Paper›PMID 33077027›Full record

ArticleeLife2020

Neuronal octopamine signaling regulates mating-induced germline stem cell increase in female

Yuto Yoshinari, Tomotsune Ameku, Shu Kondo, Hiromu Tanimoto, Takayuki Kuraishi, Yuko Shimada-Niwa, Ryusuke Niwa

Open access · goldAbstract read
In one paragraph

Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 47 citations in OpenAlex.

  1. Article
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  4. Octopamine receptors inFrontiers in molecular neuroscience · 2026
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  6. Female membrane proteins regulate postmating ovulation inProceedings of the National Academy of Sciences of the United States of America · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Yuto YoshinariGraduate School of Life and Environmental Sciences, University of Tsukuba, Tsukuba, Japan.
Tomotsune AmekuGraduate School of Life and Environmental Sciences, University of Tsukuba, Tsukuba, Japan.
Shu KondoInvertebrate Genetics Laboratory, National Institute of Genetics, Mishima, Japan.
Hiromu TanimotoGraduate School of Life Sciences, Tohoku University, Sendai, Japan.ORCID 0000-0001-5880-6064
Takayuki KuraishiFaculty of Pharmacy, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan.
Yuko Shimada-NiwaLife Science Center for Survival Dynamics, Tsukuba Advanced Research Alliance (TARA), University of Tsukuba, Tsukuba, Japan.ORCID 0000-0001-5757-4329
Ryusuke NiwaLife Science Center for Survival Dynamics, Tsukuba Advanced Research Alliance (TARA), University of Tsukuba, Tsukuba, Japan.ORCID 0000-0002-1716-455X
University of Tsukuba · JPKanazawa University · JPNational Institute of Genetics · JPTohoku University · JP

Funding

Japan Agency for Medical Research and Development 17gm6010011h0001Japan Agency for Medical Research and Development 19gm1110001h0003Japan Society for the Promotion of Science KAKENHI 15J00652Japan Society for the Promotion of Science KAKENHI 17H01378Japan Society for the Promotion of Science KAKENHI 18J20572Japan Society for the Promotion of Science KAKENHI 19H05240Japan Society for the Promotion of Science KAKENHI 26250001
6 · The paper itself

Abstract

Stem cells fuel the development and maintenance of tissues. Many studies have addressed how local signals from neighboring niche cells regulate stem cell identity and their proliferative potential. However, the regulation of stem cells by tissue-extrinsic signals in response to environmental cues remains poorly understood. Here we report that efferent octopaminergic neurons projecting to the ovary are essential for germline stem cell (GSC) increase in response to mating in female

Indexed as

Cell ProliferationSexual Behavior, AnimalSignal TransductionAnimalsDrosophila melanogasterFemaleNeuronsOctopamineStem CellsOctopamineacetylcholinedevelopmental biologyD. melanogastergermline stem cellmatingmatrix metalloproteinaseoctopaminestem cell niche

Identifiers

PMID33077027
PMCPMC7591258
OpenAlexW3092969945

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.