ArticleEpidemiology and psychiatric sciences2020
Parity and the risk of incident dementia: a COSMIC study.
Article in Epidemiology and psychiatric sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 47 citations in OpenAlex.
- Associations between female sex-specific risk factors and cardiometabolic multimorbidity: evidence from the UK Biobank cohort study.BMC public health · 2026Article
- Epigenome-Wide DNA Methylation Levels During Pregnancy: Associations with Parity Across Diverse Populations.Epigenomes · 2026Article
- Women's reproductive life patterns, intrinsic capacity, and the risk of all-cause and cause-specific dementia: a prospective cohort study.Alzheimer's research & therapy · 2026Article
- Lifetime Exposure to Endogenous Estradiol and Markers of Dementia Risk: Associations with Later Life Cognitive, Behavioral, and Functional Complaints.Diagnostics (Basel, Switzerland) · 2026Article
- Multiparity exacerbates Aβ accumulation and promotes cellular senescence in a mouse model of amyloidosis.Immunity & ageing : I & A · 2026Article
- [Association Study of Parity With Adverse Pregnancy Outcomes].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2026Article
- Women's midlife: the front line of Alzheimer prevention.The Journal of clinical investigation · 2026Review
- Adverse childhood experiences, early menopause, cognition, and dementia in older adults in the United States.Communications health · 2026Article
- Pregnancy and breastfeeding are associated with less later-life cognitive decline in a longitudinal, prospective cohort.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Lower birth rate, greater female dementia risk: global and regional patterns and public health implications.Future science OA · 2025Article
- Association Between Menopause Age and Estradiol-Based Hormone Therapy With Cognitive Performance in Cognitively Normal Women in the CLSA.Neurology · 2025Observational
- Article
- Leveraging research into sex differences and steroid hormones to improve brain health.Nature reviews. Endocrinology · 2025Review
- Number of children and dementia risk: a causal mediation analysis using data from the HUNT study linked with national registries in Norway.BMC neurology · 2025Article
- Comprehensive metabolomics profiling reveals novel biomarkers and pathways for early detection of Alzheimer's disease.Brain communications · 2025Article
- Research Note: The Association Between Parity and Odds of Alzheimer's Disease and Dementias Status.Demography · 2024Article
- Impact of the South African Child Support Grant on memory decline and dementia probability in rural and low-income mothers, 2014-2021.Social science & medicine (1982) · 2024Article
- Sex differences in cognitive decline among middle-aged and older adults: a cohort study in Europe.Age and ageing · 2024Article
- Article
- Associations of reproductive factors and exogenous estrogens with global and domain-specific cognition in later life.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
Corrections and comments
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Authors and funding
35 authors at 19 institutions in 8 countries.
Funding
Abstract
aimsTo investigate the association between parity and the risk of incident dementia in women.
methodsWe pooled baseline and follow-up data for community-dwelling women aged 60 or older from six population-based, prospective cohort studies from four European and two Asian countries. We investigated the association between parity and incident dementia using Cox proportional hazards regression models adjusted for age, educational level, hypertension, diabetes mellitus and cohort, with additional analysis by dementia subtype (Alzheimer dementia (AD) and non-Alzheimer dementia (NAD)).
resultsOf 9756 women dementia-free at baseline, 7010 completed one or more follow-up assessments. The mean follow-up duration was 5.4 ± 3.1 years and dementia developed in 550 participants. The number of parities was associated with the risk of incident dementia (hazard ratio (HR) = 1.07, 95% confidence interval (CI) = 1.02-1.13). Grand multiparity (five or more parities) increased the risk of dementia by 30% compared to 1-4 parities (HR = 1.30, 95% CI = 1.02-1.67). The risk of NAD increased by 12% for every parity (HR = 1.12, 95% CI = 1.02-1.23) and by 60% for grand multiparity (HR = 1.60, 95% CI = 1.00-2.55), but the risk of AD was not significantly associated with parity.
conclusionsGrand multiparity is a significant risk factor for dementia in women. This may have particularly important implications for women in low and middle-income countries where the fertility rate and prevalence of grand multiparity are high.
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