Evidence map›Paper›PMID 33076994›Full record

ArticleMolecular autism2020

Social attention to activities in children and adults with autism spectrum disorder: effects of context and age.

Dzmitry A Kaliukhovich, Nikolay V Manyakov, Abigail Bangerter, Seth Ness, Andrew Skalkin, Matthew S Goodwin, Geraldine Dawson, Robert L Hendren, Bennett Leventhal, Caitlin M Hudac and 3 more

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Molecular autism, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02668991 (A Study to Assess the Janssen Autism Knowledge Engine in Children and Adults With Autism Spectrum Disorder and in a Normally Developing Cohort), which is not on this map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02668991 completednot on this map

A Study to Assess the Janssen Autism Knowledge Engine in Children and Adults With Autism Spectrum Disorder and in a Normally Developing Cohort

TypeobservationalSponsorJanssen Research & Development, LLCRan2015 to 2016Enrolled186ConditionsAutism Spectrum Disorder
3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Gaze and social functioning associations in autism spectrum disorder: A systematic review and meta-analysis.Autism research : official journal of the International Society for Autism Research · 2022
    Pooled it
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  9. [Machine learning algorithms for identifying autism spectrum disorder through eye-tracking in different intention videos].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2024
    Article
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  12. Unique dynamic profiles of social attention in autistic females.Journal of child psychology and psychiatry, and allied disciplines · 2022
    Article
  13. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 9 institutions in 2 countries.

Dzmitry A KaliukhovichJanssen Pharmaceutica NV, Turnhoutseweg 30, 2340, Beerse, Belgium. dkaliukh@its.jnj.com.ORCID 0000-0002-7476-5730
Nikolay V ManyakovJanssen Pharmaceutica NV, Turnhoutseweg 30, 2340, Beerse, Belgium.ORCID 0000-0001-9037-1400
Abigail BangerterJanssen Research & Development, LLC, 1125 Trenton-Harbourton Road, Titusville, NJ, 08560, USA.
Seth NessJanssen Research & Development, LLC, 1125 Trenton-Harbourton Road, Titusville, NJ, 08560, USA.
Andrew SkalkinDatagrok, INC, 1800 JFK Blvd Suite 300 PMB 90078, Philadelphia, PA, 19103, USA.
Matthew S Goodwin312E Robinson Hall, Department of Health Sciences, Bouvé College of Health Sciences, Northeastern University, 360 Huntington Avenue, Boston, MA, 02115, USA.
Geraldine DawsonDuke Center for Autism and Brain Development and Duke Institute for Brain Sciences, Duke University School of Medicine, 2608 Erwin Road, Suite 30, Durham, NC, 27705, USA.
Robert L HendrenBenioff Children's Hospital, University of California, San Francisco, 401 Parnassus Avenue, Langley Porter, San Francisco, CA, 94143-0984, USA.
Bennett LeventhalBenioff Children's Hospital, University of California, San Francisco, 401 Parnassus Avenue, Langley Porter, San Francisco, CA, 94143-0984, USA.
Caitlin M HudacCenter for Youth Development and Intervention, University of Alabama, Box 870348, Tuscaloosa, AL, 35487-0348, USA.
Jessica BradshawDepartment of Psychology, University of South Carolina, 1512 Pendleton Street, Columbia, SC, 29201, USA.
Frederick ShicDepartment of Pediatrics, Seattle Children's Research Institute, Center for Child Health, Behavior and Development, University of Washington, 6200 NE 74th Street, Ste 110, Seattle, WA, 98115-8160, USA.
Gahan PandinaJanssen Research & Development, LLC, 1125 Trenton-Harbourton Road, Titusville, NJ, 08560, USA.
Janssen (United States) · USJanssen (Belgium) · BEUniversity of California, San Francisco · USDuke University · USGfK (United States) · USNortheastern University · USSeattle Children's Hospital · USUniversity of Alabama · USUniversity of South Carolina · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Heart Defined Attention in Infancy: Predicting Social Communication and ASD SymptomologyK23MH120476 · NIMH · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI BRADSHAW, JESSICA · 2019 to 2023
$939k
Components of Limited Activity Monitoring in Toddlers with ASDR03MH092618 · NIMH · YALE UNIVERSITY · PI CHAWARSKA, KATARZYNA, SHIC, FREDERICK · 2011 to 2012
$166k
NCATS NIH HHS UL1 TR001863NIMH NIH HHS K23 MH120476NIMH NIH HHS R03 MH092618
6 · The paper itself

Abstract

backgroundDiminished visual monitoring of faces and activities of others is an early feature of autism spectrum disorder (ASD). It is uncertain whether deficits in activity monitoring, identified using a homogeneous set of stimuli, persist throughout the lifespan in ASD, and thus, whether they could serve as a biological indicator ("biomarker") of ASD. We investigated differences in visual attention during activity monitoring in children and adult participants with autism compared to a control group of participants without autism.

methodsEye movements of participants with autism (n = 122; mean age [SD] = 14.5 [8.0] years) and typically developing (TD) controls (n = 40, age = 16.4 [13.3] years) were recorded while they viewed a series of videos depicting two female actors conversing while interacting with their hands over a shared task. Actors either continuously focused their gaze on each other's face (mutual gaze) or on the shared activity area (shared focus). Mean percentage looking time was computed for the activity area, actors' heads, and their bodies.

resultsCompared to TD participants, participants with ASD looked longer at the activity area (mean % looking time: 58.5% vs. 53.8%, p < 0.005) but less at the heads (15.2% vs. 23.7%, p < 0.0001). Additionally, within-group differences in looking time were observed between the mutual gaze and shared focus conditions in both participants without ASD (activity: Δ = - 6.4%, p < 0.004; heads: Δ = + 3.5%, p < 0.02) and participants with ASD (bodies: Δ = + 1.6%, p < 0.002). LIMITATIONS: The TD participants were not as well characterized as the participants with ASD. Inclusion criteria regarding the cognitive ability [intelligence quotient (IQ) > 60] limited the ability to include individuals with substantial intellectual disability.

conclusionsDifferences in attention to faces could constitute a feature discriminative between individuals with and without ASD across the lifespan, whereas between-group differences in looking at activities may shift with development. These findings may have applications in the search for underlying biological indicators specific to ASD. Trial registration ClinicalTrials.gov identifier NCT02668991.

Indexed as

Social BehaviorAdolescentAdultAge FactorsAttentionAutism Spectrum DisorderChildFemaleHumansMaleMiddle AgedPhotic StimulationTask Performance and AnalysisYoung AdultActivity monitoringAutism spectrum disorderBiomarkersEye trackingSocial attention

Identifiers

PMID33076994
PMCPMC7574440
OpenAlexW3092986059

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.