Evidence map›Paper›PMID 33076908›Full record

ArticleRespiratory research2020

Upper airway lengthening caused by weight increase in obstructive sleep apnea patients.

Hongyi Lin, Huahui Xiong, Changjin Ji, Cunting Wang, Yong Li, Yunqiang An, Geng Li, Jianggui Guo, Xiaoqing Huang, Han Zhang and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Respiratory research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
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  10. [Effect of mouth breathing on upper airway structure in patients with obstructive sleep apnea].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2023
    Article
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  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

Hongyi LinSchool of Biomedical Engineering, Capital Medical University, 10 Xitoutiao, Youanmenwai, Beijing, 100069, China.
Huahui XiongSchool of Biomedical Engineering, Capital Medical University, 10 Xitoutiao, Youanmenwai, Beijing, 100069, China.
Changjin JiSchool of Biomedical Engineering, Capital Medical University, 10 Xitoutiao, Youanmenwai, Beijing, 100069, China.
Cunting WangSchool of Biomedical Engineering, Capital Medical University, 10 Xitoutiao, Youanmenwai, Beijing, 100069, China.
Yong LiSchool of Biomedical Engineering, Capital Medical University, 10 Xitoutiao, Youanmenwai, Beijing, 100069, China.
Yunqiang AnSchool of Biomedical Engineering, Capital Medical University, 10 Xitoutiao, Youanmenwai, Beijing, 100069, China.
Geng LiSchool of Biomedical Engineering, Capital Medical University, 10 Xitoutiao, Youanmenwai, Beijing, 100069, China.
Jianggui GuoSchool of Biomedical Engineering, Capital Medical University, 10 Xitoutiao, Youanmenwai, Beijing, 100069, China.
Xiaoqing HuangSchool of Biomedical Engineering, Capital Medical University, 10 Xitoutiao, Youanmenwai, Beijing, 100069, China.
Han ZhangSchool of Biomedical Engineering, Capital Medical University, 10 Xitoutiao, Youanmenwai, Beijing, 100069, China.
Hong LiuSchool of Biomedical Engineering, Capital Medical University, 10 Xitoutiao, Youanmenwai, Beijing, 100069, China.
Ting LiDepartment of Radiology, Beijing Tongren Hospital, Capital Medical University, No 1 Dongjiaominxiang Street, Beijing, 100730, China.
Zheng LiDepartment of Radiology, Beijing Tongren Hospital, Capital Medical University, No 1 Dongjiaominxiang Street, Beijing, 100730, China.
Junfang XianDepartment of Radiology, Beijing Tongren Hospital, Capital Medical University, No 1 Dongjiaominxiang Street, Beijing, 100730, China. cjr.xianjunfang@vip.163.com.
Yaqi HuangSchool of Biomedical Engineering, Capital Medical University, 10 Xitoutiao, Youanmenwai, Beijing, 100069, China. yqhuang@ccmu.edu.cn.ORCID http://orcid.org/0000-0001-6811-5021
Capital Medical University · CNBeijing Tongren Hospital · CN

Funding

Key Projects in Science and Technology Program of Beijing Municipal Education Commission, China KZ201210025022National Natural Science Foundation of China 31670959, 81171422National Science and Technology Pillar Program of China 2012BAI05B03
6 · The paper itself

Abstract

backgroundThe longer upper airway is more collapsible during sleep. This study aims to reveal relationships among upper airway length, weight, and obstructive sleep apnea (OSA), particularly to answer why the upper airway of OSA patients is longer than that of healthy people and why some obese people suffer from OSA while others do not.

methodsWe perform head and neck MRI on male patients and controls, and measure > 20 morphological parameters, including several never before investigated, to quantify the effect of weight change on upper airway length.

resultsThe upper airway length is longer in patients and correlates strongly to body weight. Weight increase leads to significant fat infiltration in the tongue, causing the hyoid to move downward and lengthen the airway in patients. The apnea-hypopnea index (AHI) strongly correlates to airway length and tongue size. Surprisingly, a distance parameter h and angle β near the occipital bone both show significant differences between healthy males and patients due to their different head backward tilt angle, and strongly correlates with AHI. The contributions of downward hyoid movement and head tilt on airway lengthening are 67.4-80.5% and19.5-32.6%, respectively, in patients. The parapharyngeal fat pad also correlates strongly with AHI.

conclusionsThe findings in this study reveal that the amount of body weight and distribution of deposited fat both affect airway length, and therefore OSA. Fat distribution plays a larger impact than the amount of weight, and is a better predictor of who among obese people are more prone to OSA.

Indexed as

AdultBody Fat DistributionHeadHumansMagnetic Resonance ImagingMaleMiddle AgedNeckPolysomnographySleep Apnea, ObstructiveTongueWeight GainBody weight effectObstructive sleep apneaUpper airway length

Identifiers

PMID33076908
PMCPMC7574450
OpenAlexW3093202675

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.