ArticleBMC complementary medicine and therapies2020
Assessment of the anti-virulence potential of extracts from four plants used in traditional Chinese medicine against multidrug-resistant pathogens.
Article in BMC complementary medicine and therapies, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9 citing papers in PubMed, 22 citations in OpenAlex.
- Prevention and Treatment ofPathogens (Basel, Switzerland) · 2026Review
- Chinese herbal medicine as adjunct therapy improves clinical recovery and reduces multidrug-resistant bacterial load in older adults with pulmonary infection: a retrospective cohort study.Frontiers in medicine · 2026Article
- Quorum sensing inhibition by South African medicinal plants species: an in vitro and an untargeted metabolomics study.BMC complementary medicine and therapies · 2025Article
- Characterization of tryptanthrin as an antibacterial reagent inhibiting Vibrio splendidus.Applied microbiology and biotechnology · 2024Article
- Artemisinins inhibit oral candidiasis caused by Candida albicans through the repression on its hyphal development.International journal of oral science · 2023Article
- Chemical profiling and rapid discrimination ofChinese herbal medicines · 2023Article
- Simultaneous Determination and Pharmacokinetics Study of Three Triterpenes fromMolecules (Basel, Switzerland) · 2022Article
- Combination of Sanguisorbigenin and Conventional Antibiotic Therapy for Methicillin-ResistantInternational journal of molecular sciences · 2022Article
- Total Saponins Isolated from Corni Fructus via Ultrasonic Microwave-Assisted Extraction Attenuate Diabetes in Mice.Foods (Basel, Switzerland) · 2021Article
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7 authors at 1 institution in 1 country.
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Abstract
backgroundMultidrug-resistant pathogens are resistant to many antibiotics and associated with serious infections. Amomum tsaoko Crevost et Lemaire, Sanguisorba officinalis, Terminalia chebula Retz and Salvia miltiorrhiza Bge, are all used in Traditional Chinese Medicine (TCM) against multidrug-resistant pathogens, and the purpose of this study was to evaluate the antibacterial and anti-virulence activity of extracts derived from them.
methodsThe antibacterial activity of ethanol and aqueous extracts from these four plants was examined against several multi-drug resistant bacterial strains, and their anti-virulence potential (including quorum quenching activity, biofilm inhibition, and blocking production of virulence factor δ-toxin) was assessed against different S. aureus strains. The chemical composition of the most effective extract was determined by LC-FTMS.
resultsOnly extracts from S. officinalis and A. tsaoko were shown to exhibit limited growth inhibition activity at a dose of 256 μg·mL-1. The S. officinalis ethanol extract, the ethanol and aqueous extract of A. tsaoko, and the aqueous extract of S. miltiorrhiza all demonstrated quorum quenching activity, but didn't significantly inhibit bacterial growth. The ethanol extract of S. officinalis inhibited bacterial toxin production and biofilm formation at low concentrations. Chemical composition analysis of the most effective extract of S. officinalis showed that it mainly contained saponins.
conclusionsThe most active extract tested in this study was the ethanol root extract of S. officinalis. It inhibited δ-toxin production and biofilm formation at low concentrations and saponins may be its key active components. While the four plants showed no direct antibacterial effects, their anti-virulence properties may be key to fighting bacterial infections.
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