Evidence map›Paper›PMID 33076854›Full record

ArticleBMC medical genetics2020

Investigation of INDEL variants in apoptosis: the relevance to gastric cancer.

Giovanna Chaves Cavalcante, Milene Raiol de Moraes, Cristina Maria Duarte Valente, Caio Santos Silva, Antônio André Conde Modesto, Paula Baraúna de Assumpção, Paulo Pimentel de Assumpção, Sidney Santos, Ândrea Ribeiro-Dos-Santos

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC medical genetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
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  3. Investigation ofBiomedicines · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Giovanna Chaves CavalcanteLaboratório de Genética Humana e Médica, Programa de Pós-Graduação em Genética e Biologia Molecular, Universidade Federal do Pará, Av. Augusto Correa 01, Belém, Pará, 66075-110, Brazil.
Milene Raiol de MoraesLaboratório de Genética Humana e Médica, Programa de Pós-Graduação em Genética e Biologia Molecular, Universidade Federal do Pará, Av. Augusto Correa 01, Belém, Pará, 66075-110, Brazil.
Cristina Maria Duarte ValenteLaboratório de Genética Humana e Médica, Programa de Pós-Graduação em Genética e Biologia Molecular, Universidade Federal do Pará, Av. Augusto Correa 01, Belém, Pará, 66075-110, Brazil.
Caio Santos SilvaLaboratório de Genética Humana e Médica, Programa de Pós-Graduação em Genética e Biologia Molecular, Universidade Federal do Pará, Av. Augusto Correa 01, Belém, Pará, 66075-110, Brazil.
Antônio André Conde ModestoNúcleo de Pesquisas em Oncologia, Programa de Pós-Graduação em Oncologia e Ciências Médicas, Universidade Federal do Pará, Belém, Pará, 66073-005, Brazil.
Paula Baraúna de AssumpçãoNúcleo de Pesquisas em Oncologia, Programa de Pós-Graduação em Oncologia e Ciências Médicas, Universidade Federal do Pará, Belém, Pará, 66073-005, Brazil.
Paulo Pimentel de AssumpçãoNúcleo de Pesquisas em Oncologia, Programa de Pós-Graduação em Oncologia e Ciências Médicas, Universidade Federal do Pará, Belém, Pará, 66073-005, Brazil.
Sidney SantosLaboratório de Genética Humana e Médica, Programa de Pós-Graduação em Genética e Biologia Molecular, Universidade Federal do Pará, Av. Augusto Correa 01, Belém, Pará, 66075-110, Brazil.
Ândrea Ribeiro-Dos-SantosLaboratório de Genética Humana e Médica, Programa de Pós-Graduação em Genética e Biologia Molecular, Universidade Federal do Pará, Av. Augusto Correa 01, Belém, Pará, 66075-110, Brazil. akelyufpa@gmail.com.ORCID 0000-0001-7001-1483
Universidade Federal do Pará · BR

Funding

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 3381/2013
6 · The paper itself

Abstract

backgroundApoptosis is a type of cell death involved in different pathways inherent to the cell and the evasion from this mechanism has been related to cancer, although this process remains not very well comprehended. Gastric cancer (GC) is one of the most incident and aggressive types of cancer worldwide. In this study, we analyzed the distribution of INDEL variants in GC patients (Case) and individuals from the general population (Control) from the Amazon region, in which GC is remarkably frequent.

methodsA panel of nine INDEL markers in apoptosis-related genes (BCL2 rs11269260, CASP3 rs4647655, CASP8 rs3834129 and rs59308963, CASP9 rs4645982 and rs61079693, FADD rs4197, FAS rs10562972 and TP53 rs17880560) was developed and genotyped by multiplex PCR in both groups.

resultsIn our analyses, only marker rs4197 (FADD gene) was associated to GC development as follows: INS/DEL genotype of rs4197 increasing in about 2-fold the chances of developing this type of cancer (P = 0.046; OR = 1.940; 95%CI = 1.011-3.725).

conclusionOur results suggest that rs4197 (FADD gene) might play a role in gastric carcinogenesis in the investigated population. More studies are needed to clarify this relation. Here, we highlight the importance of investigating INDEL variants in genes involved in apoptosis.

Indexed as

INDEL MutationPolymorphism, Single NucleotideApoptosisBiomarkers, TumorCaspase 3Caspase 8Caspase 9Fas-Associated Death Domain Proteinfas ReceptorGenetic Predisposition to DiseaseGenotypeProto-Oncogene Proteins c-bcl-2Stomach NeoplasmsTumor Suppressor Protein p53Biomarkers, TumorCASP3 protein, humanCASP8 protein, humanCASP9 protein, humanCaspase 3Caspase 8Caspase 9FADD protein, humanFas-Associated Death Domain ProteinFAS protein, humanfas ReceptorProto-Oncogene Proteins c-bcl-2Tumor Suppressor Protein p53ApoptosisFADDGastric CancerINDEL

Identifiers

PMID33076854
PMCPMC7574166
OpenAlexW3092968804

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.