ArticleJournal of clinical medicine2020
Normative Database for All Retinal Layer Thicknesses Using SD-OCT Posterior Pole Algorithm and the Effects of Age, Gender and Axial Lenght.
Article in Journal of clinical medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Estimating Accelerated Retinal Decline in Mental Health Disorders Through Normative Modeling.Schizophrenia bulletin · 2026Article
- Red-green disease: overreliance on color-coded OCT RNFL analysis in glaucoma diagnosis.Eye (London, England) · 2026Article
- Comments on "Comparative analysis of retinal thickness between type 1 and type 2 diabetes mellitus patients with similar disease duration: A cross-sectional study".Indian journal of ophthalmology · 2026Article
- Retinal peripapillary nerve fiber and retinal ganglion cell layer thickening preceed atrophy in children and teenagers with optic disc drusen.Scientific reports · 2025Observational
- Normative prospective data on automatically quantified retinal morphology correlated to retinal function in healthy ageing eyes by two microperimetry devices.Acta ophthalmologica · 2025Article
- Macular perfusion alterations in people with recent-onset diabetes and novel diabetes subtypes.Diabetologia · 2025Observational
- Retinal neurodegeneration, neuroretinal rim analysis and choroid thickness in pseudoexfoliation syndrome with spectral domain optical coherence tomography.Scientific reports · 2025Article
- Exploring the impact of age and gender on retinal and choroidal thickness and vascular densities: a comprehensive analysis.International journal of retina and vitreous · 2025Article
- Deep Learning-Based SD-OCT Layer Segmentation Quantifies Outer Retina Changes in Patients With Biallelic RPE65 Mutations Undergoing Gene Therapy.Investigative ophthalmology & visual science · 2025Article
- Macular thickness measured via optic coherence tomography in healthy adults aged 45 years and older: The Brazilian Amazon Region Eye Survey.Arquivos brasileiros de oftalmologia · 2025Article
- Idiopathic Parkinson's Disease and Neuro-ophthalmological Findings: A Study on Neurodegeneration in the Retinal Nerve Fiber Layer and Cognitive Functions.Noro psikiyatri arsivi · 2025Article
- Optic Nerve Head Morphology and Macula Ganglion Cell Inner Plexiform Layer Thickness in Axially Anisometropic Rhesus Monkeys.Investigative ophthalmology & visual science · 2024Article
- Choroidal and Retinal Thicknesses in Healthy Eyes Measured with Ultra-Wide-Field Optical Coherence Tomography.Diagnostics (Basel, Switzerland) · 2024Article
- Characterisation of the normal human ganglion cell-inner plexiform layer using widefield optical coherence tomography.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2024Article
- Association of retinal neurodegeneration with the progression of cognitive decline in Parkinson's disease.NPJ Parkinson's disease · 2024Article
- Analysis of the outer retinal thickness pixel maps for the screening of hydroxychloroquine retinopathy.International ophthalmology · 2023Article
- Evaluation of Retinal Nerve Fiber Layer and Macular Ganglion Cell Layer Thickness in Relation to Optic Disc Size.Journal of clinical medicine · 2023Article
- Optical coherence tomography in multiple sclerosis.Medical hypothesis, discovery & innovation ophthalmology journal · 2023Article
- Sex-related difference in the retinal structure of young adults: a machine learning approach.Frontiers in medicine · 2023Article
- Mapping the thickness of retinal layers using Spectralis spectral domain optical coherence tomography in Indian eyes.Indian journal of ophthalmology · 2022Article
Corrections and comments
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Authors and funding
6 authors.
Funding
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Abstract
Our aim was to provide, for the first time, reference thickness values for the SD-OCT posterior pole algorithm (PPA) available for Spectralis OCT device (Heidelberg Engineering, Heidelberg, Germany) and to analyze the correlations with age, gender and axial length. We recruited 300 eyes of 300 healthy Caucasian subjects between 18 and 84 years. By PPA, composed of 64 (8 × 8) cells, we analyzed the thickness of the following macular layers: retinal nerve fiber layer (RNFL), ganglion cell layer (GCL), inner plexiform layer (IPL), inner nuclear layer (INL), outer plexiform layer (OPL), outer nuclear layer (ONL), retinal pigment epithelium (RPE), inner retina, outer retina and full retina. Mean ± SD, 1st, 5th, 95th percentiles were obtained for each cell at all macular layers. Significant negative correlations were found between age and thickness for most macular layers. The mean thickness of most macular layers was thicker for men than women, except for RNFL, OPL and RPE, with no gender differences. GCL, IPL and INL thicknesses positively correlated with axial length in central cells, and negatively in the cells near the optic disk. The mean RNFL thickness was positively associated with axial length. This is the first normative database for PPA. Age, gender and axial length should be taken into account when interpreting PPA results.
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