Evidence map›Paper›PMID 33076526›Full record

ArticlePolymers2020

Kappa-Carrageenan-Based Dual Crosslinkable Bioink for Extrusion Type Bioprinting.

Wonseop Lim, Gyeong Jin Kim, Hyun Woo Kim, Jiyeon Lee, Xiaowei Zhang, Min Gyeong Kang, Jeong Wook Seo, Jae Min Cha, Hyun Jin Park, Min-Young Lee and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Polymers, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

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  15. A dual-gelling poly(Bioactive materials · 2022
    Article
  16. Review
  17. Article
  18. Review
  19. Bioink Formulation and Machine Learning-Empowered Bioprinting Optimization.Frontiers in bioengineering and biotechnology · 2022
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Wonseop LimKU Convergence Science and Technology Institute, Department of Stem Cell and Regenerative Biotechnology, Konkuk University, Seoul 05029, Korea.
Gyeong Jin KimDepartment of Bioindustrial Technologies, College of Animal Bioscience and Technology, Konkuk University, Seoul 05029, Korea.
Hyun Woo KimDepartment of Biotechnology, College of Life Science and Biotechnology, Korea University, Anam-Dong, Seongbuk-Gu, Seoul 02841, Korea.
Jiyeon LeeKU Convergence Science and Technology Institute, Department of Stem Cell and Regenerative Biotechnology, Konkuk University, Seoul 05029, Korea.
Xiaowei ZhangKU Convergence Science and Technology Institute, Department of Stem Cell and Regenerative Biotechnology, Konkuk University, Seoul 05029, Korea.
Min Gyeong KangDepartment of Bioindustrial Technologies, College of Animal Bioscience and Technology, Konkuk University, Seoul 05029, Korea.
Jeong Wook SeoKU Convergence Science and Technology Institute, Department of Stem Cell and Regenerative Biotechnology, Konkuk University, Seoul 05029, Korea.
Jae Min ChaDepartment of Mechatronics, College of Engineering, Incheon National University, Incheon 22012, Korea.
Hyun Jin ParkDepartment of Biotechnology, College of Life Science and Biotechnology, Korea University, Anam-Dong, Seongbuk-Gu, Seoul 02841, Korea.
Min-Young LeeSmart Healthcare Research Institute, Biomedical Engineering Research Center, Samsung Medical Center, 81, Irwon-ro, Gangnam-gu, Seoul 06351, Korea.
Su Ryon ShinDivision of Engineering in Medicine, Department of Medicine, Harvard Medical School, Brigham and Women's Hospital, Cambridge, MA 02139, USA.
Seon Young ShinKU Convergence Science and Technology Institute, Department of Stem Cell and Regenerative Biotechnology, Konkuk University, Seoul 05029, Korea.
Hojae BaeKU Convergence Science and Technology Institute, Department of Stem Cell and Regenerative Biotechnology, Konkuk University, Seoul 05029, Korea.

Funding

National Research Foundation of Korea NRF-2015R1A5A1009701, NRF-2016M3A9B6946859, NRF-2018R1D1A1B05047274
6 · The paper itself

Abstract

Bioink based 3D bioprinting is a promising new technology that enables fabrication of complex tissue structures with living cells. The printability of the bioink depends on the physical properties such as viscosity. However, the high viscosity bioink puts shear stress on the cells and low viscosity bioink cannot maintain complex tissue structure firmly after the printing. In this work, we applied dual crosslinkable bioink using Kappa-carrageenan (κ-CA) to overcome existing shortcomings. κ-CA has properties such as biocompatibility, biodegradability, shear-thinning and ionic gelation but the difficulty of controlling gelation properties makes it unsuitable for application in 3D bioprinting. This problem was solved by synthesizing methacrylated Kappa-carrageenan (MA-κ-CA), which can be dual crosslinked through ionic and UV (Ultraviolet) crosslinking to form hydrogel using NIH-3T3 cells. Through MA substitutions, the rheological properties of the gel could be controlled to reduce the shear stress. Moreover, bioprinting using the cell-laden MA-κ-CA showed cell compatibility with enhanced shape retention capability. The potential to control the physical properties through dual crosslinking of MA-κ-CA hydrogel is expected to be widely applied in 3D bioprinting applications.

Indexed as

3D bioprintingdual crosslinking hydrogelkappa-carrageenanmethacrylic anhydride

Identifiers

PMID33076526
PMCPMC7602869

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.