Evidence map›Paper›PMID 33076477›Full record

ReviewInternational journal of molecular sciences2020

Synthetic Biology on Acetogenic Bacteria for Highly Efficient Conversion of C1 Gases to Biochemicals.

Sangrak Jin, Jiyun Bae, Yoseb Song, Nicole Pearcy, Jongoh Shin, Seulgi Kang, Nigel P Minton, Philippe Soucaille, Byung-Kwan Cho

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Valine overproduction inMetabolic engineering communications · 2026
    Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Genome-wide CRISPRi screen identifies enhanced autolithotrophic phenotypes in acetogenic bacteriumProceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  13. Deletion of genes linked to the CFrontiers in bioengineering and biotechnology · 2023
    Article
  14. Article
  15. EstablishingApplied and environmental microbiology · 2022
    Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sangrak JinDepartment of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 34141, Korea.ORCID 0000-0003-4363-5148
Jiyun BaeDepartment of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 34141, Korea.
Yoseb SongDepartment of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 34141, Korea.
Nicole PearcyBBSRC/EPSRC Synthetic Biology Research Centre (SBRC), School of Life Sciences, University Park, The University of Nottingham, Nottingham NG7 2RD, UK.
Jongoh ShinDepartment of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 34141, Korea.
Seulgi KangDepartment of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 34141, Korea.
Nigel P MintonBBSRC/EPSRC Synthetic Biology Research Centre (SBRC), School of Life Sciences, University Park, The University of Nottingham, Nottingham NG7 2RD, UK.ORCID 0000-0002-9277-1261
Philippe SoucailleBBSRC/EPSRC Synthetic Biology Research Centre (SBRC), School of Life Sciences, University Park, The University of Nottingham, Nottingham NG7 2RD, UK.
Byung-Kwan ChoDepartment of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 34141, Korea.

Funding

The C1 Gas Refinery Program 2018M3D3A1A01055733The Korea-France Partnership Program for C1 Refinery 2018K1A3A1A21044063
6 · The paper itself

Abstract

Synthesis gas, which is mainly produced from fossil fuels or biomass gasification, consists of C1 gases such as carbon monoxide, carbon dioxide, and methane as well as hydrogen. Acetogenic bacteria (acetogens) have emerged as an alternative solution to recycle C1 gases by converting them into value-added biochemicals using the Wood-Ljungdahl pathway. Despite the advantage of utilizing acetogens as biocatalysts, it is difficult to develop industrial-scale bioprocesses because of their slow growth rates and low productivities. To solve these problems, conventional approaches to metabolic engineering have been applied; however, there are several limitations owing to the lack of required genetic bioparts for regulating their metabolic pathways. Recently, synthetic biology based on genetic parts, modules, and circuit design has been actively exploited to overcome the limitations in acetogen engineering. This review covers synthetic biology applications to design and build industrial platform acetogens.

Indexed as

AcetatesBiodegradation, EnvironmentalClostridiumGenetic EngineeringIndustrial MicrobiologyNatural GasSynthetic BiologyAcetatesNatural Gasacetogenic bacteriaC1 gas fixationCRISPR-Cassynthetic biology

Identifiers

PMID33076477
PMCPMC7589590

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.