Evidence map›Paper›PMID 33076385›Full record

ArticleBiomolecules2020

TRPA1 Expression in Synovial Sarcoma May Support Neural Origin.

Francesco De Logu, Filippo Ugolini, Chiara Caporalini, Annarita Palomba, Sara Simi, Francesca Portelli, Domenico Andrea Campanacci, Giovanni Beltrami, Daniela Massi, Romina Nassini

Open access · goldAbstract read
In one paragraph

Article in Biomolecules, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Primary Intraosseous Synovial Sarcoma in the Mandible.Case reports in oncological medicine · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Francesco De LoguSection of Clinical Pharmacology and Oncology, Department of Health Sciences, University of Florence, 50139 Florence, Italy.ORCID 0000-0001-8360-6929
Filippo UgoliniSection of Pathological Anatomy, Department of Health Sciences, University of Florence, 50139 Florence, Italy.
Chiara CaporaliniPathology Unit, Meyer Children's Hospital, 50139 Florence, Italy.
Annarita PalombaSection of Pathological Anatomy, Department of Health Sciences, University of Florence, 50139 Florence, Italy.
Sara SimiSection of Pathological Anatomy, Department of Health Sciences, University of Florence, 50139 Florence, Italy.
Francesca PortelliSection of Pathological Anatomy, Department of Health Sciences, University of Florence, 50139 Florence, Italy.
Domenico Andrea CampanacciOrthopedics and Traumatology Section, Department of Health Sciences, University of Florence, 50139 Florence, Italy.ORCID 0000-0002-3912-3943
Giovanni BeltramiOrthopedics and Traumatology Section, Department of Health Sciences, University of Florence, 50139 Florence, Italy.
Daniela MassiSection of Pathological Anatomy, Department of Health Sciences, University of Florence, 50139 Florence, Italy.
Romina NassiniSection of Clinical Pharmacology and Oncology, Department of Health Sciences, University of Florence, 50139 Florence, Italy.ORCID 0000-0002-9223-8395
University of Florence · ITMeyer Children's Hospital · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Synovial sarcoma (SS) is a malignant mesenchymal soft tissue neoplasm. Despite its name, the cells of origin are not synovial cells, but rather neural, myogenic, or multipotent mesenchymal stem cells have been proposed as possible cells originators. Unlike other sarcomas, an unusual presentation of long-term pain at the tumor site has been documented, but the exact mechanisms have not been fully clarified yet. The transient receptor potential ankyrin 1 (TRPA1) is a nonselective cation channel mainly expressed in primary sensory neurons, where it functions as a pain sensor. TRPA1 have also been described in multiple non-excitable cells, including those derived from neural crest stem cells such as glial cells and, in particular, Schwann cell oligodendrocytes and astrocytes. We evaluated TRPA1 expression in SS. We selected a cohort of 41 SSs, and by immunohistochemistry, we studied TRPA1 expression

Indexed as

AdolescentAdultAgedBiomarkers, TumorFemaleGene Expression Regulation, NeoplasticHumansMaleMesenchymomaMiddle AgedNeural Stem CellsSarcoma, SynovialSoft Tissue NeoplasmsTRPA1 Cation ChannelYoung AdultBiomarkers, TumorTRPA1 Cation ChannelTRPA1 protein, humanneural stem cellssynovial sarcomaTRPA1

Identifiers

PMID33076385
PMCPMC7602570
OpenAlexW3092694927

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.