Evidence map›Paper›PMID 33076345›Full record

ArticleNutrients2020

Supplementation with Resveratrol, Piperine and Alpha-Tocopherol Decreases Chronic Inflammation in a Cluster of Older Adults with Metabolic Syndrome.

Raúl Francisco Pastor, Marisa Gabriela Repetto, Fabiana Lairion, Alberto Lazarowski, Amalia Merelli, Zulma Manfredi Carabetti, Isabel Pastor, Elena Pastor, Laura Valeria Iermoli, Carlos Amadeo Bavasso and 1 more

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Nutrients, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05981053 (Biological Effects in Consumers of Resveratrol-enriched Wine), which is not on this map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05981053 completednot on this mapstarted 2022, after this paper: background citation

Biological Effects in Consumers of Resveratrol-enriched Wine

TypeobservationalSponsorPINER Pastor Manfredi WineryRan2022 to 2023Enrolled30ConditionsAging, Healthy Aging, Sarcopenia, ObesityArmsWine enriched with Resveratrol
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Article
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Raúl Francisco PastorUnidad Polifenoles, Vino y Salud, Cuarta Cátedra de Medicina, Hospital de Clínicas "José de San Martín" Facultad de Medicina, Universidad de Buenos Aires, City of Buenos Aires C1120AAF, Argentina.ORCID 0000-0002-1722-8445
Marisa Gabriela RepettoDepartamento de Físicoquímica y Química Analítica, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires; Instituto de Bioquímica y Medicina Molecular (IBIMOL) Consejo Nacional de Ciencia y Tecnología (UBA-CONICET), City of Buenos Aires C1113AAD, Argentina.
Fabiana LairionDepartamento de Físicoquímica y Química Analítica, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires; Instituto de Bioquímica y Medicina Molecular (IBIMOL) Consejo Nacional de Ciencia y Tecnología (UBA-CONICET), City of Buenos Aires C1113AAD, Argentina.
Alberto LazarowskiDepartamento de Bioquímica Clínica, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Instituto de Fisiopatología y Bioquímica Clínica (INFIBIOC), Buenos Aires C1113AAD, Argentina.ORCID 0000-0001-8979-7631
Amalia MerelliDepartamento de Bioquímica Clínica, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Instituto de Fisiopatología y Bioquímica Clínica (INFIBIOC), Buenos Aires C1113AAD, Argentina.
Zulma Manfredi CarabettiUnidad Polifenoles, Vino y Salud, Cuarta Cátedra de Medicina, Hospital de Clínicas "José de San Martín" Facultad de Medicina, Universidad de Buenos Aires, City of Buenos Aires C1120AAF, Argentina.
Isabel PastorUnidad Polifenoles, Vino y Salud, Cuarta Cátedra de Medicina, Hospital de Clínicas "José de San Martín" Facultad de Medicina, Universidad de Buenos Aires, City of Buenos Aires C1120AAF, Argentina.
Elena PastorUnidad Polifenoles, Vino y Salud, Cuarta Cátedra de Medicina, Hospital de Clínicas "José de San Martín" Facultad de Medicina, Universidad de Buenos Aires, City of Buenos Aires C1120AAF, Argentina.
Laura Valeria IermoliUnidad Polifenoles, Vino y Salud, Cuarta Cátedra de Medicina, Hospital de Clínicas "José de San Martín" Facultad de Medicina, Universidad de Buenos Aires, City of Buenos Aires C1120AAF, Argentina.
Carlos Amadeo BavassoUnidad Polifenoles, Vino y Salud, Cuarta Cátedra de Medicina, Hospital de Clínicas "José de San Martín" Facultad de Medicina, Universidad de Buenos Aires, City of Buenos Aires C1120AAF, Argentina.
Roberto Héctor IermoliUnidad Polifenoles, Vino y Salud, Cuarta Cátedra de Medicina, Hospital de Clínicas "José de San Martín" Facultad de Medicina, Universidad de Buenos Aires, City of Buenos Aires C1120AAF, Argentina.
Universidad de Buenos Aires · ARConsejo Nacional de Investigaciones Científicas y Técnicas · AR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Metabolic Syndrome (MetS) is increasing worldwide regardless of culture, genetic, gender, and geographic differences. While multiple individual risk factors, such as obesity, hypertension, diabetes, and hyperlipidemia, can cause cardiovascular disease (CVD), it is the intercurrence of these risk factors that defines MetS as a cluster that creates an environment for atherosclerosis and other manifestations of CVD. Despite the advances in the knowledge and management of each of the components of MetS, there are two molecular biology processes, chronic inflammation and oxidative stress, which are still underdiagnosed and undertreated. In order to assess the effect of a dietary supplement on chronic inflammation in MetS, we conducted a clinical trial with volunteers receiving a formula composed of resveratrol, piperine and alpha tocopherol (FRAMINTROL

Indexed as

Dietary SupplementsAgedAlkaloidsalpha-TocopherolBenzodioxolesBiomarkersChronic DiseaseC-Reactive ProteinFemaleFerritinsHumansInflammationLuminescent MeasurementsMaleMetabolic SyndromeMiddle AgedAlkaloidsalpha-TocopherolBenzodioxolesBiomarkersC-Reactive ProteinFerritinsPiperidinespiperinePolyunsaturated AlkamidesResveratrolalpha-tocopherolchronic inflammationmetabolic syndromepiperineresveratrol

Identifiers

PMID33076345
PMCPMC7602615
OpenAlexW3092671565

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.