ReviewAntioxidants (Basel, Switzerland)2020
Primary Dysmenorrhea in Relation to Oxidative Stress and Antioxidant Status: A Systematic Review of Case-Control Studies.
Review in Antioxidants (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 59 citations in OpenAlex.
- Adjuvant use of melatonin for pain management in dysmenorrhea - a randomized double-blinded, placebo-controlled trial.European journal of clinical pharmacology · 2022Trial
- Pharmacological Effects of Wenjing Decoction in a Rat Model of Cold Coagulation and Blood Stasis Primary Dysmenorrhea: An Integrated Analysis of Serum Pharmacochemistry, Network Pharmacology and Metabolomics.Pharmaceuticals (Basel, Switzerland) · 2026Article
- Study on the Role of the AMPK/PGC-1α Pathway in Cold-Induced Vascular Endothelial Cell Apoptosis and Uterine Damage.Biology · 2026Article
- Daily turmeric and ginger beverage consumption attenuates physical menstrual cycle symptoms in sub-elite female footballers: a pilot study.Physical activity and nutrition · 2026Article
- Evaluating the Therapeutic Effects ofPediatric health, medicine and therapeutics · 2026Review
- Neutrophil extracellular traps in gynecological disease: pathogenic mechanisms and therapeutic opportunities.Frontiers in medicine · 2026Review
- Endogenous mediators in regulating primary dysmenorrhea.Frontiers in cell and developmental biology · 2026Review
- Real-World Evidence Shows Gaps in Awareness, Medical Help-Seeking, and Diagnosis for Primary Dysmenorrhea but Not Premenstrual Syndrome: Cross-Sectional Observational Study.Journal of medical Internet research · 2025Observational
- Primary Dysmenorrhea Induced Using Diethylstilbestrol and Oxytocin Induces Impaired Uterine Reactivity in Virgin Female Wistar Rats.Pharmaceuticals (Basel, Switzerland) · 2025Article
- The influence of primary dysmenorrhea on chronotypes, social jetlag, and night eating habits: a cross-sectional study of anxiety and depression.BMC women's health · 2025Article
- Exploring the role of negative expectations and emotions in primary dysmenorrhea: insights from a case-control study.BMC women's health · 2025Article
- The link between tinnitus and menstrual cycle disorders in premenopausal women.Scientific reports · 2025Article
- Article
- Mangiferin: An effective agent against human malignancies.Food science & nutrition · 2024Review
- Effect of Yoga and Naturopathy on Sleep Quality and Pain in PCOS Patients with Primary Dysmenorrhea: A Case Series.Integrative medicine (Encinitas, Calif.) · 2024Article
- Prevalence of chronic pelvic pain and associated factors among indigenous women of reproductive age in Ecuador.BMC women's health · 2024Article
- The effect of antioxidant supplementation on dysmenorrhea and endometriosis-associated painful symptoms: a systematic review and meta-analysis of randomized clinical trials.Obstetrics & gynecology science · 2024Article
- Article
- The Changes in Menstrual and Menstrual-Related Symptoms among Japanese Female University Students: A Prospective Cohort Study from Three Months to Nine Months after Admission.Healthcare (Basel, Switzerland) · 2023Article
- Adherence to the Mediterranean Diet in Women and Reproductive Health across the Lifespan: A Narrative Review.Nutrients · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Primary dysmenorrhea is defined as painful menstrual cramps of uterine origin in the absence of pelvic pathology and is the most common gynecological disorder among women of reproductive age. The aim of this study was to systematically review case-control studies that have investigated the oxidative stress, antioxidant status, and inflammation markers among women with primary dysmenorrhea and controls. The study protocol was registered with PROSPERO (no. CRD42020183104). By searching PubMed and Scopus databases as well as reference lists, six case-control studies with fifteen eligible markers (seven oxidative stress, seven antioxidant status, one inflammation) were included in this review. The quality of the included studies was assessed as medium or high. The systematic review included 175 women with primary dysmenorrhea and 161 controls. The results indicate an elevated level of oxidative stress, especially of lipid peroxidation among dysmenorrheal women. For the antioxidant status, limited evidence was found for a lower status among primary dysmenorrhea women, and only one study examined one inflammation marker (hs-CRP), which makes it impossible for such a conclusion. To establish whether oxidative stress, antioxidant status or inflammation participate in the pathophysiology of primary dysmenorrhea, high-quality studies with larger study groups and clear case definitions are needed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.