Evidence map›Paper›PMID 33076218›Full record

ReviewInternational journal of molecular sciences2020

Pathophysiology and Treatment of Stroke: Present Status and Future Perspectives.

Diji Kuriakose, Zhicheng Xiao

7 registry-linked trialsAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 7 registered trials, which are not on this map. Cited by 560 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
560citing papers in PubMed, 13 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05449951 naunknown statusnot on this mapstarted 2022, after this paper: background citation

Effect of Dry Needling on Spasticity in Stroke Survivors

TypeinterventionalSponsorShifa Tameer-e-Millat UniversityRan2022 to 2022Enrolled34ConditionsSpastic HemiplegiaArmsDry needling, sustained stretching
NCT05856045 naunknown statusnot on this mapstarted 2023, after this paper: background citation

Effects of Proprioceptive Neuromuscular Facilitation Exercises Versus Perturbation-based Balance Training on Balance, Coordination and Proprioception in Subacute Stroke Patients

TypeinterventionalSponsorRiphah International UniversityRan2023 to 2023Enrolled40ConditionsStrokeArmsPNF(proprioceptive neuromuscular facilitation exercises), PBBT (pertubation based balance training), PNF and PBBT intervention group
NCT05931172 naunknown statusnot on this mapstarted 2023, after this paper: background citation

Comparative Effects of Dual Task and Proprioceptive Neuromuscular Facilitation on Balance ,Cognition and Motor Function in Chronic Stroke Patients

TypeinterventionalSponsorRiphah International UniversityRan2023 to 2023Enrolled32ConditionsStrokeArmsDual tasking, PNF(proprioceptive neuromuscular facilitation exercises)
NCT06108440 nacompletednot on this mapstarted 2023, after this paper: background citation

Comparative Effects of Action Observation and Motor Imagery Training on Upper Limb Function in Chronic Stroke Patients

TypeinterventionalSponsorRiphah International UniversityRan2023 to 2024Enrolled44ConditionsStroke, Upper Extremity Paresis, Motor ActivityArmsaction observation training, motor imagery training
NCT06715098 nacompletednot on this mapstarted 2023, after this paper: background citation

Comparison of Robot Assisted Gait Training and Body Weight Supported Treadmill Training in Chronic Stroke Patients Using Gait Analysis and SEMG Measurements

TypeinterventionalSponsorPamukkale UniversityRan2023 to 2024Enrolled45ConditionsStroke, IschemicArmsRoboGait, RehaWalk, Conventional
NCT06845683 nacompletednot on this mapstarted 2024, after this paper: background citation

Effects of Dual-Task and Progressive Wall Squat Training on Cognition, Balance and Functional Mobility in Stroke Survivors

TypeinterventionalSponsorRiphah International UniversityRan2024 to 2025Enrolled50ConditionsStroke IschemicArmsGroup A, Group B
NCT07331714 nacompletednot on this mapstarted 2025, after this paper: background citation

Comparative Effects of Proprioceptive Neuromuscular Facilitation and Modified Constraint Induced Movement Therapy on Lower Limb Function in Patient With Stroke

TypeinterventionalSponsorRiphah International UniversityRan2025 to 2025Enrolled54ConditionsStrokeArmsPNF, mCIMT
3 · Its place in the literature

Who cites it

560 citing papers in PubMed, 13 syntheses or guidelines pooled it.

  1. Pooled it
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  6. Safety and effectiveness of Co-careldopa for motor recovery in post-stroke patients: A Systematic Review.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Pooled it
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  14. Trial
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  17. IBRO neuroscience reports · 2026
    Article
  18. Review
  19. Article
  20. Review

500 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Diji KuriakoseDevelopment and Stem Cells Program, Monash Biomedicine Discovery Institute and Department of Anatomy and Developmental Biology, Monash University, Melbourne, VIC 3800, Australia.ORCID 0000-0003-1067-7296
Zhicheng XiaoDevelopment and Stem Cells Program, Monash Biomedicine Discovery Institute and Department of Anatomy and Developmental Biology, Monash University, Melbourne, VIC 3800, Australia.

Funding

Apex Biotech Research NA
6 · The paper itself

Abstract

Stroke is the second leading cause of death and a major contributor to disability worldwide. The prevalence of stroke is highest in developing countries, with ischemic stroke being the most common type. Considerable progress has been made in our understanding of the pathophysiology of stroke and the underlying mechanisms leading to ischemic insult. Stroke therapy primarily focuses on restoring blood flow to the brain and treating stroke-induced neurological damage. Lack of success in recent clinical trials has led to significant refinement of animal models, focus-driven study design and use of new technologies in stroke research. Simultaneously, despite progress in stroke management, post-stroke care exerts a substantial impact on families, the healthcare system and the economy. Improvements in pre-clinical and clinical care are likely to underpin successful stroke treatment, recovery, rehabilitation and prevention. In this review, we focus on the pathophysiology of stroke, major advances in the identification of therapeutic targets and recent trends in stroke research.

Indexed as

AnimalsFibrinolytic AgentsHumansNeuroprotective AgentsRisk FactorsStem Cell TransplantationStrokeStroke RehabilitationFibrinolytic AgentsNeuroprotective Agentsneurological deficitpathophysiologyrecoveryrehabilitationstroketreatment

Identifiers

PMID33076218
PMCPMC7589849

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

and 1 more above

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.