Evidence map›Paper›PMID 33075725›Full record

ArticleBiosensors & bioelectronics2021

Ultra-sensitive viral glycoprotein detection NanoSystem toward accurate tracing SARS-CoV-2 in biological/non-biological media.

Seyyed Alireza Hashemi, Nader Ghaleh Golab Behbahan, Sonia Bahrani, Seyyed Mojtaba Mousavi, Ahmad Gholami, Seeram Ramakrishna, Mohammad Firoozsani, Mohsen Moghadami, Kamran Bagheri Lankarani, Navid Omidifar

Open access · greenAbstract readEvaluation Study
In one paragraph

Article in Biosensors & bioelectronics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 1 synthesis or guideline pooled it, 117 citations in OpenAlex.

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  4. Two-Dimensional (2D) materials in the detection of SARS-CoV-2.Microchemical journal : devoted to the application of microtechniques in all branches of science · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Seyyed Alireza HashemiDepartment of Medical Nanotechnology, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran; Center for Nanofibers and Nanotechnology, National University of Singapore, Singapore. Electronic address: sa_hashemi@sums.ac.ir.
Nader Ghaleh Golab BehbahanDepartment of Poultry Disease, Razi Vaccine and Serum Research Institute, Shiraz Branch, Agricultural Research, Education and Extension Organization (AREEO), Shiraz, Iran. Electronic address: n.ghalehgolab@rvsri.ac.ir.
Sonia BahraniDepartment of Medical Nanotechnology, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address: s_bahrani@sums.ac.ir.
Seyyed Mojtaba MousaviDepartment of Medical Nanotechnology, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran; Department of Chemical Engineering, National Taiwan University of Science and Technology, Taiwan.
Ahmad GholamiBiotechnology Research Center and Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Shiraz University of Medical Science, Shiraz, Iran.
Seeram RamakrishnaCenter for Nanofibers and Nanotechnology, National University of Singapore, Singapore. Electronic address: seeram@nus.edu.sg.
Mohammad FiroozsaniMember of Board of Trustees, Zand Institute of Higher Education, Shiraz, Iran.
Mohsen MoghadamiNon-Communicable Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address: moghadami@sums.ac.ir.
Kamran Bagheri LankaraniHealth Policy Research Center, Health Institute, Shiraz University of Medica Sciences, Shiraz, Iran.
Navid OmidifarDepartment of Pathology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Shiraz University of Medical Sciences · IRNational University of Singapore · SGRazi Vaccine and Serum Research Institute · IRShiraz University · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rapid person-to-person transfer of viruses such as SARS-CoV-2 and their occasional mutations owing to the human activity and climate/ecological changes by the mankind led to creation of wrecking worldwide challenges. Such fast transferable pathogens requiring practical diagnostic setups to control their transfer chain and stop sever outbreaks in early stages of their appearance. Herein, we have addressed this urgent demand by designing a rapid electrochemical diagnostic kit composed of fixed/screen printed electrodes that can detect pathogenic viruses such as SARS-CoV-2 and/or animal viruses through the differentiable fingerprint of their viral glycoproteins at different voltage positions. The working electrode of developed sensor is activated upon coating a layer of coupled graphene oxide (GO) with sensitive chemical compounds along with gold nanostars (Au NS) that can detect the trace of viruses in any aquatic biological media (e.g., blood, saliva and oropharyngeal/nasopharyngeal swab) through interaction with active functional groups of their glycoproteins. The method do not require any extraction and/or biomarkers for detection of target viruses and can identify trace of different pathogenic viruses in about 1 min. The nanosensor also demonstrated superior limit of detection (LOD) and sensitivity of 1.68 × 10

Indexed as

Clinical Laboratory TechniquesAnimalsBetacoronavirusBiosensing TechniquesCoronavirus InfectionsCOVID-19COVID-19 TestingElectrochemical TechniquesElectrodesEquipment DesignGoldGraphiteHumansLimit of DetectionMetal NanoparticlesPandemicsGoldgraphene oxideGraphiteSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2Electrochemical detectionNanosensorOutbreakSARS-CoV-2Virus

Identifiers

PMID33075725
PMCPMC7558249
OpenAlexW3092886840

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.