Evidence map›Paper›PMID 33075595›Full record

Observational studyJournal of the neurological sciences2020

Cerebral venous sinus thrombosis associated with SARS-CoV-2; a multinational case series.

Ashkan Mowla, Banafsheh Shakibajahromi, Shima Shahjouei, Afshin Borhani-Haghighi, Nasrin Rahimian, Humain Baharvahdat, Soheil Naderi, Fariborz Khorvash, Davar Altafi, Seyed Amir Ebrahimzadeh and 6 more

Open access · bronzeAbstract readMulticenter StudyObservational Study
In one paragraph

Observational study in Journal of the neurological sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed, 5 pooled it
6.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 5 syntheses or guidelines pooled it, 84 citations in OpenAlex.

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  5. Sex Differences and Clinical Outcomes of Patients with Coronavirus Disease 2019 Infection and Cerebral Venous Sinus Thrombosis: A Systematic Review.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
    Pooled it
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  20. The Hospitalization Rate of Cerebral Venous Sinus Thrombosis before and during COVID-19 Pandemic Era: A Single-Center Retrospective Cohort Study.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 11 institutions in 4 countries.

Ashkan MowlaDivision of Stroke and Endovascular Neurosurgery, Department of Neurological Surgery, Keck School of Medicine, University of Southern California, California, USA.
Banafsheh ShakibajahromiClinical Neurology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Shima ShahjoueiNeurology Department, Neuroscience Institute, Geisinger Health System, PA, USA.
Afshin Borhani-HaghighiClinical Neurology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address: neuro.ab@gmail.com.
Nasrin RahimianNeurology Department, Yasrebi Hospital, Kashan, Iran.
Humain BaharvahdatDivision of Neuroendovascular Surgery, Department of Neurosurgery, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.
Soheil NaderiNeurosurgery Department, Tehran University of Medical Sciences, Tehran, Iran.
Fariborz KhorvashDepartment of Neurology, Isfahan University of Medical Sciences, Isfahan, Iran.
Davar AltafiDepartment of Neurology, Alavi Hospital, Ardabil University of Medical Sciences, Ardabil, Iran.
Seyed Amir EbrahimzadehDepartment of Radiology, Yasrebi Hospital, Kashan, Iran.
Ghasem FarahmandIranian Center of Neurological Research, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.
Alaleh Vaghefi FarIranian Center of Neurological Research, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.
Vijay K SharmaDivision of Neurology, National University Health System, School of Medicine, National University of Singapore, Singapore.
Saeideh Aghayari Sheikh NeshinNeuroscience Research Center, Guilan University of Medical Sciences, Guilan, Iran.
Georgios TsivgoulisSecond Department of Neurology, National and Kapodistrian University of Athens, School of Medicine, "Attikon" University Hospital, Athens, Greece; Neurology Department, University of Tennessee Health Science Center, TN, USA.
Ramin ZandNeurology Department, Neuroscience Institute, Geisinger Health System, PA, USA; Neurology Department, University of Tennessee Health Science Center, TN, USA. Electronic address: rzand@geisinger.edu.
Tehran University of Medical Sciences · IRShiraz University of Medical Sciences · IRArdabil University of Medical Sciences · IRGeisinger Health System · USGeisinger Neuroscience Institute · USGhaem Hospital · IRGuilan University of Medical Sciences · IRIsfahan University of Medical Sciences · IRNational University Health System · SGUniversity of Southern California · USUniversity of Tennessee Health Science Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSARS-CoV-2 induced coagulopathy can lead to thrombotic complications such as stroke. Cerebral venous sinus thrombosis (CVST) is a less common type of stroke which might be triggered by COVID-19. We present a series of CVST cases with SARS-CoV-2 infection.

methodsIn a multinational retrospective study, we collected all cases of CVST in SARS-CoV-2 infected patients admitted to nine tertiary stroke centers from the beginning of the pandemic to June 30th, 2020. We compared the demographics, clinical and radiological characteristics, risk factors, and outcome of these patients with a control group of non-SARS-CoV-2 infected CVST patients in the same seasonal period of the years 2012-2016 from the country where the majority of cases were recruited.

resultsA total of 13 patients fulfilled the inclusion criteria (62% women, mean age 50.9 ± 11.2 years). Six patients were discharged with good outcomes (mRS ≤ 2) and three patients died in hospital. Compared to the control group, the SARS-CoV-2 infected patients were significantly older (50.9 versus 36.7 years, p < 0.001), had a lower rate of identified CVST risk factors (23.1% versus 84.2%, p < 0.001), had more frequent cortical vein involvement (38.5% versus 10.5%, p: 0.025), and a non-significant higher rate of in-hospital mortality (23.1% versus 5.3%, p: 0.073).

conclusionCVST should be considered as potential comorbidity in SARS-CoV-2 infected patients presenting with neurological symptoms. Our data suggest that compared to non-SARS-CoV-2 infected patients, CVST occurs in older patients, with lower rates of known CVST risk factors and might lead to a poorer outcome in the SARS-CoV-2 infected group.

Indexed as

SARS-CoV-2AdultAgedCOVID-19FemaleHumansLength of StayMaleMiddle AgedPandemicsRetrospective StudiesSinus Thrombosis, IntracranialTertiary Care CentersThrombophiliaCerebral venous sinus thrombosisCerebral venous thrombosisCOVID-19SARS-CoV-2StrokeThrombosis

Identifiers

PMID33075595
PMCPMC7556283
OpenAlexW3092873529

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.