Evidence map›Paper›PMID 33075479›Full record

ArticleNeurobiology of learning and memory2020

Acute exercise enhances fear extinction through a mechanism involving central mTOR signaling.

Nicolette A Moya, Margaret K Tanner, Abigail M Smith, Aleezah Balolia, Jazmyne K P Davis, Kelsey Bonar, Jennifer Jaime, Troy Hubert, Jorge Silva, William Whitworth and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of learning and memory, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Nicolette A MoyaDepartment of Psychology, University of Colorado Denver, USA; Department of Integrative Biology, University of Colorado Denver, USA.
Margaret K TannerDepartment of Psychology, University of Colorado Denver, USA; Department of Integrative Biology, University of Colorado Denver, USA.
Abigail M SmithDepartment of Psychology, University of Colorado Denver, USA.
Aleezah BaloliaDepartment of Psychology, University of Colorado Denver, USA; Department of Integrative Biology, University of Colorado Denver, USA.
Jazmyne K P DavisDepartment of Psychology, University of Colorado Denver, USA.
Kelsey BonarDepartment of Psychology, University of Colorado Denver, USA.
Jennifer JaimeDepartment of Psychology, University of Colorado Denver, USA.
Troy HubertDepartment of Psychology, University of Colorado Denver, USA.
Jorge SilvaDepartment of Psychology, University of Colorado Denver, USA.
William WhitworthDepartment of Psychology, University of Colorado Denver, USA.
Esteban C LoetzDepartment of Psychology, University of Colorado Denver, USA.
Sondra T BlandDepartment of Psychology, University of Colorado Denver, USA.
Benjamin N GreenwoodDepartment of Psychology, University of Colorado Denver, USA.
University of Colorado Denver · US

Funding

PILOT STUDY--SUBSTRATE METABOLISM IN EXTREMELY LOW BIRTH WEIGHT INFANTSP30DK048520 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI Edward L Melanson · 1995 to 2026
$32.6M
Nigrostriatal Dopaminergic Modulation of Fear ExtinctionR15MH114026 · NIMH · UNIVERSITY OF COLORADO DENVER · PI GREENWOOD, BEN N · 2017 to 2020
$933k
NIDDK NIH HHS P30 DK048520NIMH NIH HHS R15 MH114026
6 · The paper itself

Abstract

Impaired fear extinction, combined with the likelihood of fear relapse after exposure therapy, contributes to the persistence of many trauma-related disorders such as anxiety and post-traumatic stress disorder. Identifying mechanisms to aid fear extinction and reduce relapse could provide novel strategies for augmentation of exposure therapy. Exercise can enhance learning and memory and augment fear extinction of traumatic memories in humans and rodents. One factor that could contribute to enhanced fear extinction following exercise is the mammalian target of rapamycin (mTOR). mTOR is a translation regulator involved in synaptic plasticity and is sensitive to many exercise signals such as monoamines, growth factors, and cellular metabolism. Further, mTOR signaling is increased after chronic exercise in brain regions involved in learning and emotional behavior. Therefore, mTOR is a compelling potential facilitator of the memory-enhancing and overall beneficial effects of exercise on mental health.The goal of the current study is to test the hypothesis that mTOR signaling is necessary for the enhancement of fear extinction produced by acute, voluntary exercise. We observed that intracerebral-ventricular administration of the mTOR inhibitor rapamycin reduced immunoreactivity of phosphorylated S6, a downstream target of mTOR, in brain regions involved in fear extinction and eliminated the enhancement of fear extinction memory produced by acute exercise, without reducing voluntary exercise behavior or altering fear extinction in sedentary rats. These results suggest that mTOR signaling contributes to exercise-augmentation of fear extinction.

Indexed as

Physical Conditioning, AnimalAnimalsBrainExtinction, PsychologicalFearMaleMemoryRats, Long-EvansSignal TransductionSirolimusTOR Serine-Threonine KinasesmTOR protein, ratSirolimusTOR Serine-Threonine KinasesExposure therapyFear conditioningNucleus accumbensRapamycinS6Wheel running

Identifiers

PMID33075479
PMCPMC7718627
OpenAlexW3093193802

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.