Evidence map›Paper›PMID 33075312›Full record

ArticleBiochemical pharmacology2021

Small cyclic sodium channel inhibitors.

Steve Peigneur, Cristina da Costa Oliveira, Flávia Cristina de Sousa Fonseca, Kirsten L McMahon, Alexander Mueller, Olivier Cheneval, Ana Cristina Nogueira Freitas, Hana Starobova, Igor Dimitri Gama Duarte, David J Craik and 4 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemical pharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 38 citations in OpenAlex.

  1. Article
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  8. Apamin structure and pharmacology revisited.Frontiers in pharmacology · 2022
    Article
  9. Article
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 4 countries.

Steve PeigneurToxicology and Pharmacology, Katholieke Universiteit (KU) Leuven, Campus Gasthuisberg, Leuven, Belgium; Department de Bioquímica e Imunologia, Laboratório de Venenos e Toxinas Animais, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo-Horizonte, Brazil.
Cristina da Costa OliveiraDepartment of Pharmacology, Institute of Biological Sciences, Federal University of Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brazil.
Flávia Cristina de Sousa FonsecaDepartment of Pharmacology, Institute of Biological Sciences, Federal University of Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brazil.
Kirsten L McMahonInstitute for Molecular Bioscience, The University of Queensland, Brisbane, Qld 4072, Australia.
Alexander MuellerInstitute for Molecular Bioscience, The University of Queensland, Brisbane, Qld 4072, Australia.
Olivier ChenevalInstitute for Molecular Bioscience, The University of Queensland, Brisbane, Qld 4072, Australia.
Ana Cristina Nogueira FreitasDepartment de Bioquímica e Imunologia, Laboratório de Venenos e Toxinas Animais, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo-Horizonte, Brazil.
Hana StarobovaInstitute for Molecular Bioscience, The University of Queensland, Brisbane, Qld 4072, Australia.
Igor Dimitri Gama DuarteDepartment of Pharmacology, Institute of Biological Sciences, Federal University of Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brazil.
David J CraikInstitute for Molecular Bioscience, The University of Queensland, Brisbane, Qld 4072, Australia.
Irina VetterInstitute for Molecular Bioscience, The University of Queensland, Brisbane, Qld 4072, Australia; School of Pharmacy, The University of Queensland, Woolloongabba, Qld 4102, Australia.
Maria Elena de LimaDepartment de Bioquímica e Imunologia, Laboratório de Venenos e Toxinas Animais, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo-Horizonte, Brazil; Santa Casa de Belo Horizonte: Instituto de Ensino e Pesquisa, Brazil.
Christina I SchroederInstitute for Molecular Bioscience, The University of Queensland, Brisbane, Qld 4072, Australia; National Cancer Institute, National Institutes of Health, Frederick, MD 21702, USA. Electronic address: christina.schroeder@nih.gov.
Jan TytgatToxicology and Pharmacology, Katholieke Universiteit (KU) Leuven, Campus Gasthuisberg, Leuven, Belgium. Electronic address: jan.tygat@kuleuven.be.
The University of Queensland · AUUniversidade Federal de Minas Gerais · BRKU Leuven · BENational Institutes of Health · US

Funding

Discovery and development of voltage-gated sodium channel inhibitorsZIABC012003 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI SCHROEDER, INGRID · 2020 to 2022
$291k
Intramural NIH HHS ZIA BC012003
6 · The paper itself

Abstract

Voltage-gated sodium (Na

Indexed as

AnimalsFemaleMaleMiceMice, Inbred C57BLPeptide FragmentsScorpion VenomsVoltage-Gated Sodium Channel BlockersVoltage-Gated Sodium ChannelsXenopus laevisOD1 toxin, Odonthobuthus doriaePeptide FragmentsScorpion VenomsVoltage-Gated Sodium Channel BlockersVoltage-Gated Sodium ChannelsCone snail toxinCyclic peptideNociceptionPainSpider toxinVoltage gated sodium channel

Identifiers

PMID33075312
PMCPMC9116130
OpenAlexW3092789660

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.