Evidence map›Paper›PMID 33075184›Full record

ArticleChemistry (Weinheim an der Bergstrasse, Germany)2021

Development of ADPribosyl Ubiquitin Analogues to Study Enzymes Involved in Legionella Infection.

Robbert Q Kim, Mohit Misra, Alexis Gonzalez, Ines Tomašković, Donghyuk Shin, Hermann Schindelin, Dmitri V Filippov, Huib Ovaa, Ivan Đikić, Gerbrand J van der Heden van Noort

Open access · hybridAbstract read
In one paragraph

Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Covalent Probes To CaptureJournal of the American Chemical Society · 2024
    Article
  4. CapturingFrontiers in molecular biosciences · 2024
    Article
  5. Article
  6. A new dawn beyond lysine ubiquitination.Nature chemical biology · 2022
    Review
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 4 countries.

Robbert Q KimOncode Institute and Department of Cell and Chemical Biology, Leiden University Medical Centre, Einthovenweg 20, 2333 ZC, Leiden, The Netherlands.
Mohit MisraInstitute of Biochemistry II, Goethe University Faculty of Medicine, Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Germany.
Alexis GonzalezInstitute of Biochemistry II, Goethe University Faculty of Medicine, Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Germany.
Ines TomaškovićInstitute of Biochemistry II, Goethe University Faculty of Medicine, Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Germany.
Donghyuk ShinInstitute of Biochemistry II, Goethe University Faculty of Medicine, Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Germany.
Hermann SchindelinRudolf Virchow Center for Integrative and Translational Bioimaging, University of Würzburg, Josef-Schneider-Strasse 2, 97080, Würzburg, Germany.
Dmitri V FilippovLeiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333 CC, Leiden, The Netherlands.
Huib OvaaOncode Institute and Department of Cell and Chemical Biology, Leiden University Medical Centre, Einthovenweg 20, 2333 ZC, Leiden, The Netherlands.
Ivan ĐikićInstitute of Biochemistry II, Goethe University Faculty of Medicine, Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Germany.
Gerbrand J van der Heden van NoortOncode Institute and Department of Cell and Chemical Biology, Leiden University Medical Centre, Einthovenweg 20, 2333 ZC, Leiden, The Netherlands.ORCID http://orcid.org/0000-0001-5955-6431
Goethe University Frankfurt · DELeiden University · NLUniversity of Würzburg · DE

Funding

Deutsches Forschungszentrum für Gesundheit und Umwelt, Helmholtz Zentrum München GRK2243Horizon 2020 Framework Programme 742720Horizon 2020 Framework Programme 765445Nederlandse Organisatie voor Wetenschappelijk Onderzoek VI.Vidi.192.011ZonMw Off-Road 451001026
6 · The paper itself

Abstract

Legionnaires' disease is caused by infection with the intracellularly replicating Gram-negative bacterium Legionella pneumophila. This pathogen uses an unconventional way of ubiquitinating host proteins by generating a phosphoribosyl linkage between substrate proteins and ubiquitin by making use of an ADPribosylated ubiquitin (Ub

Indexed as

ADP-RibosylationBacterial ProteinsHEK293 CellsHumansHydrolasesLegionella pneumophilaLegionnaires' DiseaseUbiquitinUbiquitin-Activating EnzymesUbiquitinationBacterial ProteinsHydrolasesUBA1 protein, humanUbiquitinUbiquitin-Activating EnzymesADPribosylationclick chemistryLegionellapost-translational modificationsubiquitin

Identifiers

PMID33075184
PMCPMC7898697
OpenAlexW3092915022

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.