ArticleIrish journal of medical science2021
Objective evaluation of the nasal mucosal secretion in COVID-19 patients with anosmia.
Article in Irish journal of medical science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.
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Who cites it
8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 13 citations in OpenAlex.
- Pooled it
- Pathophysiological relationship between COVID-19 and olfactory dysfunction: A systematic review.Brazilian journal of otorhinolaryngologyPooled it
- Effect of intranasal nitrilotriacetic acid trisodium salt in lowering elevated calcium cations and improving olfactory dysfunction in COVID-19 patients.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2022Article
- Article
- Frequency and Severity of Ear-Nose-Throat (ENT) Symptoms during COVID-19 Infection.Medicina (Kaunas, Lithuania) · 2022Article
- Evidence of SARS-CoV-2 in nasal brushings and olfactory mucosa biopsies of COVID-19 patients.PloS one · 2022Article
- Consequences of FFP3 mask usage on venous blood gases.Irish journal of medical science · 2021Article
- Reply to Eisenhut.American journal of physiology. Lung cellular and molecular physiology · 2021Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCOVID-19 is a new disease caused by the SARS-CoV-2 virus. The olfactory dysfunction linked to COVID-19 is not associated with rhinorrhea but there is no objective evaluation.
aimsTo evaluate nasal mucosal secretion objectively in COVID-19 patients with anosmia.
methodsFifty-two COVID-19 patients with anosmia and 51 healthy individuals included. Anosmia was diagnosed by subjective questionnaires. Nasal Schirmer test was done to the left and the right nasal cavity separately.
resultsAll patients had anosmia and 82.6% had gustatory dysfunction. In group 1, the mean of the nasal Schirmer test results in the right cavity was 12.4 mm, 12.01 mm in the left nasal cavity. The median wetting distance (right plus left divided by two) was calculated 12.21 mm. In group 2, the mean of the nasal Schirmer test results in the right cavity was 12.1 mm, 11.8 mm in the left nasal cavity. The median wetting distance (right plus left divided by two) was calculated11.97 mm. There was no difference between the two groups in terms of nasal schirmer.
conclusionOlfactory dysfunction and gustatory dysfunction are the two of the unknown for this disease. We evaluated the nasal mucosa secretions in COVID-19 patients with anosmia objectively to evaluate if there is inflammation in the nasal mucosa. We found no difference between healthy individuals. According to our study, SARS-CoV-2 causes anosmia without causing nasal mucosal inflammation. Invasion of the olfactory bulb and central nervous system by SARS-CoV-2 may lead to anosmia in COVID-19, which may cause olfactory dysfunction.
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