Evidence map›Paper›PMID 33074447›Full record

ArticleEsophagus : official journal of the Japan Esophageal Society2021

Upper mediastinal lymph node dissection based on mesenteric excision in esophageal cancer surgery: confirmation by near-infrared image-guided lymphatic mapping and the impact on locoregional control.

Hisahiro Hosogi, Daisuke Yagi, Masazumi Sakaguchi, Shin Akagawa, Yukinari Tokoro, Seiichiro Kanaya

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In one paragraph

Article in Esophagus : official journal of the Japan Esophageal Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Neoadjuvant Chemoradiotherapy Followed by Minimally Invasive Esophagectomy for Borderline Resectable Esophageal Squamous Cell Carcinoma.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2023
    Article
  6. Review
  7. Article
  8. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Hisahiro Hosogi *Department of Surgery, Japanese Red Cross Osaka Hospital, 5-30 Fudegasakicho, Tennoji Ward, Osaka, 543-8555, Japan. hisahoso@kuhp.kyoto-u.ac.jp.ORCID 0000-0002-1039-6139
Daisuke Yagi *Department of Surgery, Japanese Red Cross Osaka Hospital, 5-30 Fudegasakicho, Tennoji Ward, Osaka, 543-8555, Japan.
Masazumi SakaguchiDepartment of Surgery, Japanese Red Cross Osaka Hospital, 5-30 Fudegasakicho, Tennoji Ward, Osaka, 543-8555, Japan.
Shin AkagawaDepartment of Surgery, Japanese Red Cross Osaka Hospital, 5-30 Fudegasakicho, Tennoji Ward, Osaka, 543-8555, Japan.
Yukinari TokoroDepartment of Surgery, Japanese Red Cross Osaka Hospital, 5-30 Fudegasakicho, Tennoji Ward, Osaka, 543-8555, Japan.
Seiichiro KanayaDepartment of Surgery, Japanese Red Cross Osaka Hospital, 5-30 Fudegasakicho, Tennoji Ward, Osaka, 543-8555, Japan.
Osaka Hospital · JPKitakyushu Municipal Medical Center · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWe previously reported a novel method of mesenteric excision for esophageal cancer surgery. The esophagus, trachea, recurrent laryngeal nerves (RLNs), and surrounding lymph nodes (LNs) are contained in a common mesenterium, which we termed the "mesotracheoesophagus". In addition, near-infrared (NIR) image-guided lymphatic mapping has recently been used. The purpose of this study was to confirm the feasibility of NIR image-guided lymphatic mapping for upper mediastinal LN dissection, and to confirm the oncological feasibility of our surgical approach.

methodsFifteen patients with resectable esophageal cancer underwent submucosal injection of indocyanine green (ICG), and underwent robot-assisted esophagectomy. The frequency of ICG positivity in the LN basins along the RLNs, and metastatic frequency were assessed. Regarding the oncological feasibility of our thoracoscopic esophagectomy, the recurrence patterns and survival of 72 consecutive patients who underwent curative resection from 2011 to 2016 were analyzed.

resultsICG-positive LN basins along the right and left RLNs were found in 12 (80% of 15) patients (3 patients positive for metastatic LNs) and 11 (73% of 15) patients (2 positive for metastatic LNs and 1 false-negative), respectively. All ICG-positive LN basins were found within the mesotracheoesophagus. The sensitivity was 5/6 (83%), and the negative predictive value was 6/7 (86%). Among the 72 patients, with a median follow-up period of 1644 days, only 3 (4.2%) patients developed locoregional recurrence.

conclusionsThe NIR image-guided lymphatic mapping was feasible. Our results with no ICG-positive basins outside of the '"mesotracheoesophagus", supported our surgical approach. It might become standard, with acceptable locoregional control.

Indexed as

Esophageal NeoplasmsNeoplasm Recurrence, LocalEsophagectomyHumansLymph Node ExcisionLymph NodesEsophageal cancerLymphatic mappingMesenteric excisionRecurrence

Identifiers

PMID33074447
OpenAlexW3092737445

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.