Evidence map›Paper›PMID 33074399›Full record

ReviewCurrent neurology and neuroscience reports2020

The Regulation of Cerebral Spinal Fluid Flow and Its Relevance to the Glymphatic System.

Colin D McKnight, Renee M Rouleau, Manus J Donahue, Daniel O Claassen

Abstract readReview
In one paragraph

Review in Current neurology and neuroscience reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. The parasagittal dural space of the human brain.Brain : a journal of neurology · 2025
    Review
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. [1-Fluids and barriers of the CNS · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Colin D McKnightDepartment of Radiology, Vanderbilt University Medical Center, Nashville, TN, USA.
Renee M RouleauDepartment of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA.
Manus J DonahueDepartment of Radiology, Vanderbilt University Medical Center, Nashville, TN, USA.
Daniel O ClaassenDepartment of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA. daniel.claassen@vumc.org.

Funding

Quantification of Glymphatic Dysfunction in Patients with Alzheimer's Disease and Related DementiasR01NR015079 · NINR · VANDERBILT UNIVERSITY MEDICAL CENTER · PI DONAHUE, MANUS J · 2014 to 2022
$3.9M
Quantitative Imaging of Brain Glymphatic Function in HumansR01AG062574 · NIA · VANDERBILT UNIVERSITY MEDICAL CENTER · PI CLAASSEN, DANIEL OLIVER, DONAHUE, MANUS J · 2020 to 2024
$3.0M
NIA NIH HHS R01 AG062574NINR NIH HHS R01 NR015079
6 · The paper itself

Abstract

purpose of reviewThe glymphatic system is a relatively new concept that has been associated with regulation of cerebrospinal fluid (CSF), as well as brain waste clearance. Novel techniques to study glymphatic dysfunction have in turn prompted a reassessment of brain physiology and underlying elements of neurological disease. This review incorporates a contemporary imaging perspective focused on understanding the regulation of CSF flow, thus expanding the putative clinical relevance of this system and the relationships between CSF flow and glymphatic function. RECENT

findingsMR imaging studies, especially those that employ intrathecal gadolinium contrast, have identified potentially new pathways regulating CSF production, absorption, and clearance. These studies, when viewed in the context of more historical anatomic descriptors of CSF production and absorption, provide a more robust description of CSF physiology and waste clearance. CSF production and resorption are under-investigated and could be related to various pathophysiologic processes in neurodegeneration. Anatomically based clinical exemplars of CSF clearance are discussed. Future studies should focus on linking glymphatic functionality with neurological disease.

Indexed as

Glymphatic SystemNervous System DiseasesBrainHumansMagnetic Resonance ImagingArachnoid granulationsGlymphaticNeurodegenerationNeuroimagingPerivascular space

Identifiers

PMID33074399
PMCPMC7864223

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.