Evidence map›Paper›PMID 33074398›Full record

ArticlePflugers Archiv : European journal of physiology2021

Platinum accumulation in the brain and alteration in the central regulation of cardiovascular and respiratory functions in oxaliplatin-treated rats.

Ahmed A Rahman, Vanesa Stojanovska, Paul Pilowsky, Kulmira Nurgali

Abstract read
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In one paragraph

Article in Pflugers Archiv : European journal of physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Navigating the Complexities of Cancer Treatment-Induced Hypertension.Journal of cardiovascular development and disease · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 1 country.

Ahmed A RahmanCollege of Health and Biomedicine, Institute for Health and Sport, Victoria University, Melbourne, Australia.
Vanesa StojanovskaCollege of Health and Biomedicine, Institute for Health and Sport, Victoria University, Melbourne, Australia.
Paul PilowskyHeart Research Institute, Central Clinical School, The University of Sydney, Sydney, Australia.
Kulmira NurgaliCollege of Health and Biomedicine, Institute for Health and Sport, Victoria University, Melbourne, Australia. kulmira.nurgali@vu.edu.au.ORCID 0000-0002-2597-6929
Hudson Institute of Medical Research · AUThe University of Sydney · AUVictoria University · AUWestern Health · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oxaliplatin is a platinum-based alkylating chemotherapeutic agent used for cancer treatment. Neurotoxicity is one of its major adverse effects that often demands dose limitation. However, the effects of chronic oxaliplatin on the toxicity of the autonomic nervous system regulating cardiorespiratory function and adaptive reflexes are unknown. Male Sprague Dawley rats were treated with intraperitoneal oxaliplatin (3 mg kg

Indexed as

AnimalsAntineoplastic AgentsBaroreflexBloodCardiovascular Physiological PhenomenaChemoreceptor CellsDrug Administration ScheduleHeart RateMaleOxaliplatinPlatinumRandom AllocationRatsRats, Sprague-DawleyRespiratory Physiological PhenomenaSplanchnic NervesAntineoplastic AgentsOxaliplatinPlatinumBlood pressureChemotherapyOxaliplatinPlatinumSympathetic nerve

Identifiers

PMID33074398
OpenAlexW3093127717

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.