Trial reportClinical rheumatology2021
Efficacy of high intensity laser therapy in knee osteoarthritis: a double-blind controlled randomized study.
Trial report in Clinical rheumatology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 26 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Additional Effect of High-Intensity Laser Therapy Over Conventional Physiotherapy Related to Pain and Function in Patients With Knee Osteoarthritis: A Randomized, Double-Blind, Placebo-Controlled, 12-Week Follow-up Study
Effects of High-intensity Laser Therapy on Muscle Strength in People With Knee Osteoarthritis
Who cites it
26 citing papers in PubMed, 5 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- Comparison of laser therapy and extracorporeal shock wave therapy in the treatment of patients with plantar fasciitis: a systematic review and meta-analysis of prospective studies.Lasers in medical science · 2026Pooled it
- The importance of power in photobiomodulation: a systematic review and meta-analysis of high-intensity laser therapy.Frontiers in integrative neuroscience · 2026Pooled it
- Randomized Controlled Trials Studying Nonoperative Treatments of Osteoarthritis Often Use Misleading and Uninformative Control Groups: A Systematic Review.Clinical orthopaedics and related research · 2025Pooled it
- Adjunctive therapies in addition to land-based exercise therapy for osteoarthritis of the hip or knee.The Cochrane database of systematic reviews · 2022Pooled it
- Is high intensity laser therapy more effective than other physical therapy modalities for treating knee osteoarthritis? A systematic review and network meta-analysis.Frontiers in medicine · 2022Pooled it
- Comparison of the effectiveness of extracorporeal shock wave therapy and high-intensity laser therapy in patients with knee osteoarthritis: a single-blind randomized clinical trial.Clinical rheumatology · 2026Trial
- Comparison of the effects of high-intensity laser therapy and low-level laser therapy in knee osteoarthritis.Clinical rheumatology · 2025Trial
- Additional effect of high-intensity laser therapy with conventional physiotherapy related to pain and function in patients with knee osteoarthritis: a randomized, double-blind, placebo-controlled, 12-week follow-up study.Lasers in medical science · 2025Trial
- Efficacy of high intensity laser therapy versus sham laser in symptomatic knee osteoarthritis: a double-blind randomized controlled trial.Lasers in medical science · 2025Trial
- The effect of high-intensity laser therapy on pain and lower extremity function in patellofemoral pain syndrome: a single-blind randomized controlled trial.Lasers in medical science · 2024Trial
- Effects of high-intensity laser therapy on pain, functional status, hand grip strength, and median nerve cross-sectional area by ultrasonography in patients with carpal tunnel syndrome.Lasers in medical science · 2023Trial
- Evaluation of the effect of high-intensity laser therapy (HILT) on function, muscle strength, range of motion, pain level, and femoral cartilage thickness in knee osteoarthritis: randomized controlled study.Lasers in medical science · 2023Trial
- Short-Term Efficacy of High-Intensity Laser Therapy in Alleviating Pain in Patients with Knee Osteoarthritis: A Single-Blind Randomised Controlled Trial.Pain research & management · 2022Trial
- Combined ultrasound-guided hyaluronic acid injections, high-power laser therapy and physiotherapy improve hip function in osteoarthritis: A randomized controlled trial.Journal of experimental orthopaedics · 2026Article
- Photobiomodulation for the treatment of knee osteoarthritis: therapeutic effects and molecular mechanism.Frontiers in cell and developmental biology · 2026Review
- Efficacy analysis of high-intensity laser therapy for post lumbar surgery syndrome.Scientific reports · 2025Article
- Photobiomodulation in Promoting Cartilage Regeneration.International journal of molecular sciences · 2025Review
- The effect of high-intensity versus photobiomodulation therapy (PBM) on the regeneration of the sciatic nerve following crush injury: an animal study.Lasers in medical science · 2025Article
- Comparison of the Effect of High-Intensity Laser Therapy and Quadriceps Muscle Strengthening Exercises Using Biofeedback on Pain, Stiffness and Function of Patients with Knee Osteoarthritis: A Randomized Clinical Trial.Anesthesiology and pain medicine · 2024Article
- High-Intensity Laser Therapy in Pain Management of Knee Osteoarthritis.Biomedicines · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe aim of this study is to investigate the effectiveness of high intensity laser therapy on pain, functionality, flexion range of motion (FROM), and ultrasonographic cartilage measurement in patients with knee osteoarthritis.
methodsThis study was designed as a double-blind randomized placebo-controlled study. Forty patients diagnosed with knee osteoarthritis according to the American College of Rheumatology criteria were included in the study. After obtaining written informed consent, patients were randomized into high intensity laser therapy (HILT) + exercise therapy (ET), and placebo laser (PL) + ET groups. Each patient was treated five sessions per week for 2 weeks. The outcomes measured were pain level and functional disability using the visual analog scale (VAS) and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), respectively. The femoral cartilage thickness measurement was made ultrasonographically, and FROM was measured with goniometry.
resultsStatistically significant improvements were detected in VAS, WOMAC scores, femoral cartilage thickness, and FROM at the end of the treatment (in week 2) compared to the pre-treatment period in both groups (p < 0.05). There were significant decreases in the VAS and WOMAC scores of both groups in the 6th week compared to the pre-treatment period, and the results of the FROM and femur cartilage thickness measurements were increased at statistically significant levels (p < 0.05). The VAS and WOMAC scores were significantly lower in the 6th week in HILT + ET group compared to the PL + ET group (p < 0.05). Similarly, statistically significant increases were detected in the FROM and femur cartilage thickness measurements in HILT + ET group (p < 0.05).
conclusionHILT + ET combination was more effective in KOA than the PL + ET combination. Key Points • HILT is an effective modality on pain, functional status and FROM in patients with KOA. • HILT is a modality that increases femoral cartilage thickness in patients with KOA.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.