ArticleEuropean journal of nutrition2021
The association between periconceptional folic acid supplementation and the risk of preterm birth: a population-based retrospective cohort study of 200,000 women in China.
Article in European journal of nutrition, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 15 citations in OpenAlex.
- Trends, disparities, and socioeconomic inequalities in periconceptional folic acid supplementation in China: a nationwide survey analysis.BMC pregnancy and childbirth · 2026Observational
- Factors associated with preterm birth and low birth weight among infants with congenital heart disease in Changsha City, China, 2022-2024.Scientific reports · 2026Article
- The roles of folate, MTHFR genetics, vitamin B12 in pregnancy outcomes.Frontiers in nutrition · 2026Review
- Maternal Folic Acid Supplement Use, Folate Intake, and Preterm Birth Among Infants With Spina Bifida.Birth defects research · 2025Article
- Single-cell-level digital twins for preterm birth prevention strategies.bioRxiv : the preprint server for biology · 2025Article
- Preterm Birth as a Risk Factor for Cerebral Palsy in Children: A Systematic Review and Meta-Analysis.Neurology research international · 2025Review
- The association of preconceptional folic acid supplementation with gestational age and preterm birth risk in twin pregnancies: a prospective cohort study in China.European journal of nutrition · 2024Article
- Preterm Birth and Its Association with Maternal Diet, and Placental and Neonatal Telomere Length.Nutrients · 2023Review
- Advances in Folic Acid Biosensors and Their Significance in Maternal, Perinatal, and Paediatric Preventive Medicine.Biosensors · 2023Review
- [Association between periconceptional supplementation of folic acid or multiple-micronutrients containing folic acid and preterm delivery in women].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2023Article
- Association between season of conception, month of conception with preterm birth in China: a population-based retrospective cohort study.Reproductive health · 2023Article
- The interaction between no folic acid supplementation during early pregnancy and preeclampsia increased the risk of preterm birth.Saudi medical journal · 2023Article
- Prevalence of preterm birth and risk factors associated with it at different gestational ages: A multicenter retrospective survey in China.Saudi medical journal · 2022Article
- Nationwide-free preconception care strategy: Experience from China.Frontiers in public health · 2022Review
- Does Folic Acid Intake Play Role as a Potential Indicator of Modifiable Maternal Risk Factors in Preconception Period?: A Cross-Sectional Study.Women's health reports (New Rochelle, N.Y.)Article
- Periconceptional folic acid usage and its associated factors in eastern Sudan: A cross-sectional study.Women's health (London, England)Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
purposeThe aim of this study was to examine the association between periconceptional folic acid (FA) supplementation and risk of preterm birth.
methodsWe conducted a retrospective cohort study in women aged 18-49 who participated in the NFPHEP from 2010 to 2018, and had a singleton livebirth in 129 counties in southwest China. Participants were divided into four groups according to the time period starting FA use: no use, after the last menstrual period, at least 1-2 months before the last menstrual period, at least 3 months before the last menstrual period. The outcomes were preterm birth (gestation < 37 weeks) and early preterm birth (gestation < 34 weeks).
results201,477 women were included and 191,809 (95.2%) had taken FA during periconception. Compared with women who did not take FA, women who started taking FA 1-2 months before their last menstrual period had a 15% lower risk of preterm birth (aOR = 0.85, 95% CI 0.79-0.92), and women who started taking FA at least 3 months before their last menstrual period had a 20% lower risk of preterm birth (aOR = 0.80, 95% CI 0.75-0.87), but women who started taking FA after their last menstrual period did not appear to reduce the risk of preterm birth.
conclusionsIn this study of 200,000 Chinese women, periconceptional supplementation with FA was associated with a lower risk of preterm birth. Women who started taking FA at least 3 months before their last menstrual period were more likely to reduce the risk of preterm birth.
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