ArticleInvestigative ophthalmology & visual science2020
Effect of Body Position on Intraocular Pressure (IOP), Intracranial Pressure (ICP), and Translaminar Pressure (TLP) Via Continuous Wireless Telemetry in Nonhuman Primates (NHPs).
Article in Investigative ophthalmology & visual science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 15 citations in OpenAlex.
- Associations between Retinal Nerve Fiber Layer Thickness, Axial Length, and Generation in the 2-Continent Eye Study.Ophthalmology science · 2026Article
- Circadian Norepinephrine Rhythm Regulates Outflow Facility and IOP in Rat Eyes.Investigative ophthalmology & visual science · 2026Article
- Article
- Short-term intraocular pressure changes after intravitreal aflibercept 2 mg, aflibercept 8 mg and faricimab: a prospective, comparative study.The British journal of ophthalmology · 2025Observational
- Impact of microgravity on retinal neuroimmune responses and visual dysfunction in rats.International journal of ophthalmology · 2025Article
- Continuous Wireless Telemetric Measurement of Intraocular Pressure (IOP), Ocular Perfusion Pressure (OPP), and Cerebrospinal Fluid Pressure (CSFP) in Nonhuman Primates (NHPs).Methods in molecular biology (Clifton, N.J.) · 2025Article
- Perioperative and postoperative effects of hydrostatic pressure applied to the dura mater on central nervous system in unilateral biportal endoscopic spine surgery.Neurosciences (Riyadh, Saudi Arabia) · 2024Article
- Synchronous functional magnetic resonance eye imaging, video ophthalmoscopy, and eye surface imaging reveal the human brain and eye pulsation mechanisms.Scientific reports · 2024Article
- Effects of head-down tilt on optic nerve sheath diameter in healthy subjects.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2023Article
- Eye-brain axis in microgravity and its implications for Spaceflight Associated Neuro-ocular Syndrome.NPJ microgravity · 2023Review
- Perioperative Care of the Patient with Eye Pathologies Undergoing Nonocular Surgery.Anesthesiology · 2022Article
- Relative Contributions of Intraocular and Cerebrospinal Fluid Pressures to the Biomechanics of the Lamina Cribrosa and Laminar Neural Tissues.Investigative ophthalmology & visual science · 2022Article
- Mathematical modelling of the CSF system: effects of microstructures and posture on optic nerve subarachnoid space dynamics.Fluids and barriers of the CNS · 2022Article
- Posture-Dependent Collapse of the Optic Nerve Subarachnoid Space: A Combined MRI and Modeling Study.Investigative ophthalmology & visual science · 2021Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Purpose: Recent retrospective clinical studies and animal experiments have suggested that cerebrospinal fluid pressure (CSFP) is important in glaucoma, acting through the translaminar pressure (TLP = IOP - CSFP), which directly affects the optic nerve head. In this study, IOP and intracranial pressure (ICP; a surrogate of CSFP) were measured at various body positions to quantify the determinants of TLP. Methods: We have developed an implantable wireless pressure telemetry system based on a small piezoelectric sensor with low temporal drift. Telemetry transducers were placed in the anterior chamber to measure IOP and in the brain parenchyma at eye height to measure ICP. IOP was calibrated against anterior cannulation manometry, and ICP/CSFP was calibrated against an intraparenchymal Codman ICP Express microsensor. We measured IOP, ICP, and TLP = IOP - ICP continuously at 200 Hz in three male nonhuman primates (NHPs) in three trials; pressures were then averaged for 30 seconds per body position. Relative change of IOP, ICP, and TLP from the supine (baseline) position to the seated, standing, and inverted positions were quantified. Results: TLP changed significantly and instantaneously from the supine to seated (+14 mm Hg), supine to standing (+13 mm Hg) and supine to inverted (-12 mm Hg) positions (P < 0.05). There was no significant TLP change for supine to prone. ICP showed greater relative change than IOP. Conclusions: TLP change due to body position change is driven more by ICP/CSFP than IOP. IOP, ICP, and TLP variability, coupled with telemetry, should allow us to test the hypotheses that IOP, ICP, or TLP fluctuations contribute independently to glaucoma onset or progression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.