Evidence map›Paper›PMID 33074153›Full record

ArticleEuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology2021

Invasive assessment of myocardial bridging in patients with angina and no obstructive coronary artery disease.

Vedant Satish Pargaonkar, Takumi Kimura, Ryo Kameda, Shigemitsu Tanaka, Ryotaro Yamada, Jonathan G Schwartz, Leor Perl, Ian S Rogers, Yasuhiro Honda, Peter Fitzgerald and 2 more

Open access · greenAbstract read
In one paragraph

Article in EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 1 pooled it
5.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Evaluation and Treatment of Myocardial Bridging by Clinical Phenotype.Journal of the Society for Cardiovascular Angiography & Interventions · 2026
    Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Coronary Endothelial Dysfunction and Vasomotor Dysregulation in Myocardial Bridging.Journal of cardiovascular development and disease · 2025
    Review
  11. Article
  12. Article
  13. When Is It a Bridge Too Far?Journal of the Society for Cardiovascular Angiography & Interventions · 2024
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Dynamic perfusion SPECT for functional evaluation in symptomatic patients with myocardial bridging.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Vedant Satish PargaonkarDivision of Cardiovascular Medicine, Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, USA.
Takumi Kimura
Ryo Kameda
Shigemitsu Tanaka
Ryotaro Yamada
Jonathan G Schwartz
Leor Perl
Ian S Rogers
Yasuhiro Honda
Peter Fitzgerald
Ingela Schnittger
Jennifer Ann Tremmel
Cardiovascular Institute of the South · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsAngina and no obstructive coronary artery disease (ANOCA) is common. A potential cause of angina in this patient population is a myocardial bridge (MB). We aimed to study the anatomical and haemodynamic characteristics of an MB in patients with ANOCA. METHODS AND

resultsUsing intravascular ultrasound (IVUS), we identified 184 MBs in 154 patients. We evaluated MB length, arterial compression, and halo thickness. MB muscle index (MMI) was defined as MB length×halo thickness. Haemodynamic testing of the MB was performed using an intracoronary pressure/Doppler flow wire at rest and during dobutamine stress. We defined an abnormal diastolic fractional flow reserve (dFFR) as ≤0.76 during stress. The median MB length was 22.9 mm, arterial compression 30.9%, and halo thickness 0.5 mm. The median MMI was 12.1. Endothelial and microvascular dysfunction were present in 85.4% and 22.1%, respectively. At peak dobutamine stress, 94.2% of patients had a dFFR ≤0.76 within and/or distal to the MB. MMI was associated with an abnormal dFFR.

conclusionsIn select patients with ANOCA who have an MB by IVUS, the majority have evidence of a haemodynamically significant dFFR during dobutamine stress, suggesting the MB as being a cause of their angina. A comprehensive invasive assessment of such patients during coronary angiography provides important diagnostic information that can guide management.

Indexed as

Coronary Artery DiseaseFractional Flow Reserve, MyocardialMyocardial BridgingAngina PectorisCoronary AngiographyCoronary VesselsHumans

Identifiers

PMID33074153
PMCPMC9725037
OpenAlexW3092864179

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.