ArticleeLife2020
Open access · goldAbstract read
In one paragraph
Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed
5.1field-weighted citation impact, top 4% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
59 citing papers in PubMed, 78 citations in OpenAlex.
- Ovarian somatic tissue rejuvenates circulating apolipoproteins and promotes cognitive health in postreproductive female mice.GeroScience · 2026Article
- Older adult APOE4 mice exhibit modest immunometabolic adaptation following microglial APOE2 replacement.Neurobiology of aging · 2026Article
- Longevity and cognitive resilience in a Colombian family carrying theJournal of Alzheimer's disease : JAD · 2026Article
- Review
- Exceptional Longevity Modifying Allele APOE2 Promotes DNA Signaling Pathways Resisting Cellular Senescence in Human Neurons.Aging cell · 2026Article
- Alzheimer's Disease Risk Factor APOE4 Exerts Dimorphic Effects on Female Bone.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- APOE-stratified Proteomic and Metabolomic Analysis Reveals Mitochondrial Dysfunction Inflammation and Lipid Dysregulation in Alzheimer's Disease.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- PLCG2 signaling and genetic resilience in Alzheimer's disease.Molecular neurodegeneration · 2026Review
- Cerebrospinal fluid proteomic signatures revealResearch square · 2026Article
- Evaluating the association of apolipoprotein E genotype and cognitive resilience in SuperAgers.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Mechanistic role of APOE lipidation in Alzheimer's disease pathogenesis.Theranostics · 2026Review
- Genotype distribution and risk factors for human papillomavirus infection.Journal of gynecologic oncology · 2026Article
- Flipping APOE to reverse Alzheimer's disease traits.Nature neuroscience · 2025Article
- Effects of aging and anti-aging dietary restriction on regulators of the [NADPH]/[NADPFree radical biology & medicine · 2025Review
- ApoE is Secreted as a Lipid Nanoparticle by Mammalian Cells: Implications for Alzheimer's Disease Pathogenesis.Biochemistry · 2025Article
- Interplay between age, APOE Ɛ4 and the metabolome in plasma and brain in Alzheimer's disease.Translational psychiatry · 2025Article
- Sex andInternational journal of molecular sciences · 2025Article
- Aging, Rather than Genotype, Is the Principal Contributor to Differential Gene Expression Within Targeted Replacement APOE2, APOE3, and APOE4 Mouse Brain.Brain sciences · 2025Article
- Compression of cognitive decline and cognitive resilience in extreme longevity.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Differences and overlaps in TDP-43 pathology of 'pure' LATE-NC compared to LATE-NC coexisting with Alzheimer's disease.Acta neuropathologica · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 6 institutions in 2 countries.
Mitsuru ShinoharaDepartment of Neuroscience, Mayo Clinic, Jacksonville, United States.ORCID 0000-0003-3045-7338
Takahisa KanekiyoDepartment of Neuroscience, Mayo Clinic, Jacksonville, United States.
Masaya TachibanaDepartment of Neuroscience, Mayo Clinic, Jacksonville, United States.
Aishe KurtiDepartment of Neuroscience, Mayo Clinic, Jacksonville, United States.
Motoko ShinoharaDepartment of Neuroscience, Mayo Clinic, Jacksonville, United States.
Yuan FuDepartment of Neuroscience, Mayo Clinic, Jacksonville, United States.
Jing ZhaoDepartment of Neuroscience, Mayo Clinic, Jacksonville, United States.
Xianlin HanBarshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, San Antonio, United States.
Patrick M SullivanDuke University School of Medicine, Durham Veterans Health Administration Medical Center's Geriatric Research, Education and Clinical Center, Durham, United States.
G William RebeckDepartment of Neuroscience, Georgetown University Medical Center, Washington, United States.
John D FryerDepartment of Neuroscience, Mayo Clinic, Jacksonville, United States.ORCID 0000-0003-3390-2994
Michael G HeckmanDepartment of Neuroscience, Mayo Clinic, Jacksonville, United States.
Guojun BuDepartment of Neuroscience, Mayo Clinic, Jacksonville, United States.
Mayo Clinic in Florida · USJacksonville College · USDuke University · USGeorgetown University · USThe University of Texas Health Science Center at San Antonio · USWinnMed · US
Funding
Research Education ComponentP30AG062677 · NIA · MAYO CLINIC ROCHESTER · PI NILUFER ERTEKIN-TANER · 2019 to 2026
$33.5MTRANSGENIC COREP30AG013319 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI JAMES FLOYD NELSON · 1995 to 2026
$30.6MViral Vectors CoreP01NS074969 · NINDS · WASHINGTON UNIVERSITY · PI HOLTZMAN, DAVID M. · 2012 to 2021
$13.0MIntegrative translational discovery of vascular risk factors in aging and dementiaRF1AG051504 · NIA · MAYO CLINIC JACKSONVILLE · PI BU, GUOJUN, ERTEKIN-TANER, NILUFER · 2015 to 2019
$9.8MApoE Receptor Pathways to Intraneuronal AbetaR01AG027924 · NIA · WASHINGTON UNIVERSITY · PI LI, YONGHE · 2006 to 2021
$3.7MImpact of ApoE2 on aging-related conditionsRF1AG057181 · NIA · MAYO CLINIC JACKSONVILLE · PI KANEKIYO, TAKAHISA · 2018 to 2018
$3.7MApoE isoform-specific therapy for Alzheimer diseaseRF1AG046205 · NIA · MAYO CLINIC JACKSONVILLE · PI ZHAO, NA · 2019 to 2019
$3.1MApoE pathway in cerebrovascular Aβ clearance in Alzheimer’s diseaseR37AG027924 · NIA · MAYO CLINIC JACKSONVILLE · PI BU, GUOJUN · 2017 to 2020
$2.4MAPOE isoform affects protein structure and function in normal brainR01NS100704 · NINDS · GEORGETOWN UNIVERSITY · PI REBECK, G WILLIAM · 2017 to 2021
$2.0MApoE isoform-specific therapy for Alzheimer diseaseR01AG046205 · NIA · MAYO CLINIC JACKSONVILLE · PI BU, GUOJUN · 2013 to 2017
$1.6MReverse apoE4 effects by apoE2 expression in Alzheimer's diseaseR21AG052423 · NIA · MAYO CLINIC JACKSONVILLE · PI KANEKIYO, TAKAHISA · 2016 to 2017
$430kNIA NIH HHS P30 AG013319NIA NIH HHS P30 AG062677NIA NIH HHS R01 AG027924NIA NIH HHS R01 AG046205NIA NIH HHS R21 AG052423NIA NIH HHS RF1 AG046205NIA NIH HHS RF1 AG051504NIA NIH HHS RF1 AG057181NINDS NIH HHS P01 NS074969NINDS NIH HHS R01 NS100704
Abstract
Although the ε2 allele of apolipoprotein E (
Indexed as
Lipid MetabolismAlzheimer DiseaseAnimalsApolipoprotein E2Disease Models, AnimalHumansLongevityMiceApolipoprotein E2Alzheimer's diseaseAPOEhumanlongevitymedicinemouseneuroscience
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.