Evidence map›Paper›PMID 33073925›Full record

SynthesisHuman brain mapping2022

In vivo hippocampal subfield volumes in bipolar disorder-A mega-analysis from The Enhancing Neuro Imaging Genetics through Meta-Analysis Bipolar Disorder Working Group.

Unn K Haukvik, Tiril P Gurholt, Stener Nerland, Torbjørn Elvsåshagen, Theophilus N Akudjedu, Martin Alda, Dag Alnaes, Silvia Alonso-Lana, Jochen Bauer, Bernhard T Baune and 88 more

Open access · goldAbstract readMeta-AnalysisMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Human brain mapping, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed, 9 pooled it
6.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 9 syntheses or guidelines pooled it, 74 citations in OpenAlex.

  1. Pooled it
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  10. Trial
  11. A 3D Brain Geometry Toolkit for Multisite Neuroimaging Analysis.bioRxiv : the preprint server for biology · 2026
    Article
  12. Article
  13. Article
  14. The Regulatory Potential of Long Non-Coding RNAs in Bipolar Disorder.International journal of molecular sciences · 2026
    Review
  15. Article
  16. Review
  17. Article
  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

98 authors at 20 institutions in 17 countries.

Unn K HaukvikDepartment of Adult Mental Health, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.ORCID 0000-0002-0363-4127
Tiril P GurholtNorwegian Centre for Mental Disorders Research (NORMENT), Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.ORCID 0000-0002-1272-7616
Stener NerlandNorwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Torbjørn ElvsåshagenNorwegian Centre for Mental Disorders Research (NORMENT), Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
Theophilus N AkudjeduCentre for Neuroimaging & Cognitive Genomics (NICOG), Clinical Neuroimaging Laboratory, NCBES Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, Galway, Ireland.
Martin AldaDepartment of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada.
Dag AlnaesNorwegian Centre for Mental Disorders Research (NORMENT), Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
Silvia Alonso-LanaFIDMAG Germanes Hospitalàries Research Foundation, CIBERSAM, Barcelona, Spain.
Jochen BauerInstitute of Clinical Radiology, University of Münster, Münster, Germany.
Bernhard T BauneDepartment of Psychiatry, University of Münster, Münster, Germany.
Francesco BenedettiPsychiatry and Clinical Psychobiology, Scientific Institute Ospedale San Raffaele, Milan, Italy.
Michael BerkDeakin University, IMPACT, the Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Barwon Health, Geelong, Victoria, Australia.
Francesco BettellaNorwegian Centre for Mental Disorders Research (NORMENT), Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
Erlend BøenPsychosomatic and CL Psychiatry, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
Caterina M BonnínBarcelona Bipolar Disorders and Depressive Unit, Hospital Clinic, Institute of Neurosciences, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Spain.
Paolo BrambillaDepartment of Neurosciences and Mental Health, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Erick J Canales-RodríguezFIDMAG Germanes Hospitalàries Research Foundation, CIBERSAM, Barcelona, Spain.
Dara M CannonCentre for Neuroimaging & Cognitive Genomics (NICOG), Clinical Neuroimaging Laboratory, NCBES Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, Galway, Ireland.
Xavier CaserasMRC Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK.
Orwa DandashBrain, Mind and Society Research Hub, Turner Institute for Brain and Mental Health, School of Psychological Sciences, Monash University, Clayton, Victoria, Australia.
Udo DannlowskiDepartment of Psychiatry, University of Münster, Münster, Germany.
Giuseppe DelvecchioDepartment of Pathophysiology and Transplantation, University of Milan, Milan, Italy.
Ana M Díaz-ZuluagaResearch Group in Psychiatry, Department of Psychiatry, Faculty of Medicine, Universidad de Antioquia, Medellín, Antioquia, Colombia.
Theo G M van ErpClinical Translational Neuroscience Laboratory, Department of Psychiatry and Human Behavior, University of California Irvine, Irvine, California, USA.
Mar Fatjó-VilasFIDMAG Germanes Hospitalàries Research Foundation, CIBERSAM, Barcelona, Spain.
Sonya F FoleyCardiff University Brain Research Imaging Centre (CUBRIC), Cardiff University, Cardiff, UK.
Katharina FörsterDepartment of Psychiatry, University of Münster, Münster, Germany.
Janice M FullertonNeuroscience Research Australia, Randwick, New South Wales, Australia.
José M GoikoleaBarcelona Bipolar Disorders and Depressive Unit, Hospital Clinic, Institute of Neurosciences, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Spain.
Dominik GrotegerdDepartment of Psychiatry, University of Münster, Münster, Germany.
Oliver GruberSection for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, Heidelberg University Hospital, Heidelberg, Germany.
Bartholomeus C M HaarmanDepartment of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Beathe HaatveitNorwegian Centre for Mental Disorders Research (NORMENT), Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
Tomas HajekDepartment of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada.
Brian HallahanCentre for Neuroimaging & Cognitive Genomics (NICOG), Clinical Neuroimaging Laboratory, NCBES Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, Galway, Ireland.
Mathew HarrisDivision of Psychiatry, University of Edinburgh, Edinburgh, UK.
Emma L HawkinsDivision of Psychiatry, University of Edinburgh, Edinburgh, UK.
Fleur M HowellsDepartment of Psychiatry and Mental Health, University of Cape Town, Cape Town, Western Cape, South Africa.
Carina HülsmannDepartment of Psychiatry, University of Münster, Münster, Germany.
Neda JahanshadImaging Genetics Center, USC Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of the University of Southern California, Marina del Rey, California, USA.
Kjetil N JørgensenNorwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Tilo KircherDepartment of Psychiatry and Psychotherapy, Philipps-University Marburg, Marburg, Germany.
Bernd KrämerSection for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, Heidelberg University Hospital, Heidelberg, Germany.ORCID 0000-0002-1145-9103
Axel KrugDepartment of Psychiatry and Psychotherapy, Philipps-University Marburg, Marburg, Germany.
Rayus KuplickiLaureate Institute for Brain Research, Tulsa, Oklahoma, USA.
Trine V LagerbergNorwegian Centre for Mental Disorders Research (NORMENT), Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
Thomas M LancasterCardiff University Brain Research Imaging Centre (CUBRIC), Cardiff University, Cardiff, UK.ORCID 0000-0003-1322-2449
Rhoshel K LenrootNeuroscience Research Australia, Randwick, New South Wales, Australia.
Vera LonningNorwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Carlos López-JaramilloResearch Group in Psychiatry, Department of Psychiatry, Faculty of Medicine, Universidad de Antioquia, Medellín, Antioquia, Colombia.
Ulrik F MaltInstitute of Clinical Medicine, University of Oslo, Oslo, Norway.
Colm McDonaldCentre for Neuroimaging & Cognitive Genomics (NICOG), Clinical Neuroimaging Laboratory, NCBES Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, Galway, Ireland.
Andrew M McIntoshDivision of Psychiatry, University of Edinburgh, Edinburgh, UK.
Genevieve McPhilemyCentre for Neuroimaging & Cognitive Genomics (NICOG), Clinical Neuroimaging Laboratory, NCBES Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, Galway, Ireland.
Dennis van der MeerNorwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Ingrid MelleNorwegian Centre for Mental Disorders Research (NORMENT), Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
Elisa M T MelloniPsychiatry and Clinical Psychobiology, Scientific Institute Ospedale San Raffaele, Milan, Italy.
Philip B MitchellSchool of Psychiatry, University of New South Wales, Sydney, New South Wales, Australia.
Leila NabulsiCentre for Neuroimaging & Cognitive Genomics (NICOG), Clinical Neuroimaging Laboratory, NCBES Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, Galway, Ireland.
Igor NenadićDepartment of Psychiatry and Psychotherapy, Philipps-University Marburg, Marburg, Germany.ORCID 0000-0002-0749-7473
Viola OertelDepartment of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt am Main, Germany.
Lucio OldaniDepartment of Neurosciences and Mental Health, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Nils OpelDepartment of Psychiatry, University of Münster, Münster, Germany.
Maria C G OtaduyLIM44, Department of Radiology and Oncology, University of São Paulo, São Paulo, Brazil.
Bronwyn J OversNeuroscience Research Australia, Randwick, New South Wales, Australia.
Julian A Pineda-ZapataResearch Group in Psychiatry, Department of Psychiatry, Faculty of Medicine, Universidad de Antioquia, Medellín, Antioquia, Colombia.
Edith Pomarol-ClotetFIDMAG Germanes Hospitalàries Research Foundation, CIBERSAM, Barcelona, Spain.
Joaquim RaduaInstitut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), CIBERSAM, Barcelona, Spain.ORCID 0000-0003-1240-5438
Lisa RauerSection for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, Heidelberg University Hospital, Heidelberg, Germany.
Ronny RedlichDepartment of Psychiatry, University of Münster, Münster, Germany.ORCID 0000-0002-7018-4525
Jonathan ReppleDepartment of Psychiatry, University of Münster, Münster, Germany.ORCID 0000-0003-1379-9491
Maria M RivePsychiatry, Amsterdam UMC, Location AMC, Amsterdam, The Netherlands.
Gloria RobertsSchool of Psychiatry, University of New South Wales, Sydney, New South Wales, Australia.
Henricus G RuhePsychiatry, Amsterdam UMC, Location AMC, Amsterdam, The Netherlands.
Lauren E SalminenImaging Genetics Center, USC Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of the University of Southern California, Marina del Rey, California, USA.
Raymond SalvadorFIDMAG Germanes Hospitalàries Research Foundation, CIBERSAM, Barcelona, Spain.ORCID 0000-0001-5557-1562
Salvador SarróFIDMAG Germanes Hospitalàries Research Foundation, CIBERSAM, Barcelona, Spain.
Jonathan SavitzLaureate Institute for Brain Research, Tulsa, Oklahoma, USA.
Aart H ScheneDonders Institute for Brain, Cognition and Behavior, Radboud University, Nijmegen, The Netherlands.
Kang SimWest Region/Institute of Mental Health, Singapore, Singapore.
Marcio G Soeiro-de-SouzaDepartment of Psychiatry, Universidade de São Paulo, São Paulo, Brazil.
Michael StäbleinDepartment of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt am Main, Germany.
Dan J SteinDepartment of Psychiatry and Mental Health, University of Cape Town, Cape Town, Western Cape, South Africa.
Frederike SteinDepartment of Psychiatry and Psychotherapy, Philipps-University Marburg, Marburg, Germany.
Christian K TamnesNorwegian Centre for Mental Disorders Research (NORMENT), Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
Henk S TemminghDepartment of Psychiatry and Mental Health, University of Cape Town, Cape Town, Western Cape, South Africa.
Sophia I ThomopoulosImaging Genetics Center, USC Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of the University of Southern California, Marina del Rey, California, USA.ORCID 0000-0002-0046-4070
Dick J VeltmanDepartment of Psychiatry, Amsterdam UMC, Location VUMC, Amsterdam, The Netherlands.
Eduard VietaHospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain.
Lena WaltemateDepartment of Psychiatry, University of Münster, Münster, Germany.
Lars T WestlyeNorwegian Centre for Mental Disorders Research (NORMENT), Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.ORCID 0000-0001-8644-956X
Heather C WhalleyDivision of Psychiatry, University of Edinburgh, Edinburgh, UK.
Philipp G SämannMax Planck Institute of Psychiatry, Munich, Germany.ORCID 0000-0001-8523-3628
Paul M ThompsonImaging Genetics Center, USC Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of the University of Southern California, Marina del Rey, California, USA.
Christopher R K ChingImaging Genetics Center, USC Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of the University of Southern California, Marina del Rey, California, USA.
Ole A AndreassenNorwegian Centre for Mental Disorders Research (NORMENT), Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
Ingrid AgartzNorwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
ENIGMA Bipolar Disorder Working Group
Oslo University Hospital · NOUniversity of Münster · DEHospital Mare de Déu de la Mercè · ESOllscoil na Gaillimhe – University of Galway · IEUniversity of Oslo · NOUniversity of Southern California · USUniversity of Edinburgh · GBHeidelberg University · DEPhilipps University of Marburg · DEAmsterdam Neuroscience · NLBlack Dog Institute · AUCardiff University · GBDalhousie University · CAGoethe University Frankfurt · DELaureate Institute for Brain Research · USNeurosciences Institute · USRadboud University Nijmegen · NLThe University of Melbourne · AUUniversidad de Antioquia · COUniversidade de São Paulo · BR

Funding

The Center for Neuroscience-based Mental Health Assessment and Prediction (NEUROMAP)P20GM121312 · NIGMS · LAUREATE INSTITUTE FOR BRAIN RESEARCH · PI Masaya Misaki · 2017 to 2026
$23.7M
Training U54EB020403 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2014 to 2018
$10.1M
High resolution mapping of the genetic risk for disease in the aging brainR01AG059874 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI JAHANSHAD, NEDA · 2018 to 2022
$3.1M
ENIGMA-SD: Understanding Sex Differences in Global Mental Health through ENIGMAR01MH116147 · NIMH · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2018 to 2021
$2.5M
Training Grant in Neurobehavioral GeneticsT32MH073526 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BEARDEN, CARRIE E, GESCHWIND, DANIEL H · 2006 to 2020
$2.4M
Training in the Multiscale and Multimodal Analysis of Biomarkers in Alzheimer’s DiseaseT32AG058507 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ARTHUR W TOGA · 2018 to 2026
$2.1M
A global alliance to unlock brain mechanisms influencing suicidal behaviors through the ENIGMA ConsortiumR01MH117601 · NIMH · UNIVERSITY OF SOUTHERN CALIFORNIA · PI JAHANSHAD, NEDA, SCHMAAL, LIANNE · 2018 to 2021
$1.5M
Acute modulation of neural circuitry regulating immune function in depressionR21MH113871 · NIMH · LAUREATE INSTITUTE FOR BRAIN RESEARCH · PI SAVITZ, JONATHAN · 2018 to 2019
$477k
CIHR 106469CIHR 142255Health Research Board HRA-POR-324NIA NIH HHS R01 AG059874NIA NIH HHS T32 AG058507NIBIB NIH HHS U54 EB020403NIGMS NIH HHS P20 GM121312NIGMS NIH HHS P20GM121312NIH HHS 5T32MH073526NIH HHS R01AG059874NIH HHS R01MH116147NIH HHS R01MH117601NIH HHS T32AG058507NIH HHS U54EB020403NIMH NIH HHS R01 MH116147NIMH NIH HHS R01 MH117601NIMH NIH HHS R21 MH113871NIMH NIH HHS R21MH113871NIMH NIH HHS T32 MH073526Wellcome TrustWellcome Trust 103703Wellcome Trust 104036/Z/14/Z
6 · The paper itself

Abstract

The hippocampus consists of anatomically and functionally distinct subfields that may be differentially involved in the pathophysiology of bipolar disorder (BD). Here we, the Enhancing NeuroImaging Genetics through Meta-Analysis Bipolar Disorder workinggroup, study hippocampal subfield volumetry in BD. T1-weighted magnetic resonance imaging scans from 4,698 individuals (BD = 1,472, healthy controls [HC] = 3,226) from 23 sites worldwide were processed with FreeSurfer. We used linear mixed-effects models and mega-analysis to investigate differences in hippocampal subfield volumes between BD and HC, followed by analyses of clinical characteristics and medication use. BD showed significantly smaller volumes of the whole hippocampus (Cohen's d = -0.20), cornu ammonis (CA)1 (d = -0.18), CA2/3 (d = -0.11), CA4 (d = -0.19), molecular layer (d = -0.21), granule cell layer of dentate gyrus (d = -0.21), hippocampal tail (d = -0.10), subiculum (d = -0.15), presubiculum (d = -0.18), and hippocampal amygdala transition area (d = -0.17) compared to HC. Lithium users did not show volume differences compared to HC, while non-users did. Antipsychotics or antiepileptic use was associated with smaller volumes. In this largest study of hippocampal subfields in BD to date, we show widespread reductions in nine of 12 subfields studied. The associations were modulated by medication use and specifically the lack of differences between lithium users and HC supports a possible protective role of lithium in BD.

Indexed as

Magnetic Resonance ImagingNeuroimagingBipolar DisorderGeneticsHippocampusHumansbipolar disorder subtypehippocampuslarge-scalelithiumpsychosisstructural brain MRI

Identifiers

PMID33073925
PMCPMC8675404
OpenAlexW3092994192

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.