ArticleHuman brain mapping2021
Shared and distinct global signal topography disturbances in subcortical and cortical networks in human epilepsy.
Article in Human brain mapping, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- A systematic review of global signal topography in aging, neuropsychiatric disorders, and cognitive task performance.Brain imaging and behavior · 2026Pooled it
- Individual-specific resting-state networks predict language dominance in drug-resistant epilepsy.medRxiv : the preprint server for health sciences · 2025Article
- Altered Global Signal Topography in Major Depressive Disorder With and Without Anxiety.Depression and anxiety · 2025Article
- The selfish network: how the brain preserves behavioral function through shifts in neuronal network state.Trends in neurosciences · 2024Review
- Hierarchical fluctuation shapes a dynamic flow linked to states of consciousness.Nature communications · 2023Article
- Effective Early Detection of Epileptic Seizures through EEG Signals Using Classification Algorithms Based on t-Distributed Stochastic Neighbor Embedding and K-Means.Diagnostics (Basel, Switzerland) · 2023Article
- Gestational age-related changes in the fetal functional connectome: in utero evidence for the global signal.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Local and Global Abnormalities in Pre-symptomatic Huntington's Disease Revealed by 7T Resting-state Functional MRI.Neuroscience bulletin · 2023Article
- Beyond noise to function: reframing the global brain activity and its dynamic topography.Communications biology · 2022Review
- Expression profile of synaptic vesicle glycoprotein 2A, B, and C paralogues in temporal neocortex tissue from patients with temporal lobe epilepsy (TLE).Molecular brain · 2022Article
- Altered topological organization of resting-state functional networks in children with infantile spasms.Frontiers in neuroscience · 2022Article
- Altered Global Signal Topography in Alcohol Use Disorders.Frontiers in aging neuroscience · 2022Article
- BOLD Coupling between Lesioned and Healthy Brain Is Associated with Glioma Patients' Recovery.Cancers · 2021Article
- Shared and distinct global signal topography disturbances in subcortical and cortical networks in human epilepsy.Human brain mapping · 2021Article
- Global Signal Topography of the Human Brain: A Novel Framework of Functional Connectivity for Psychological and Pathological Investigations.Frontiers in human neuroscience · 2021Review
- Resting-state MEG of whole-brain functional network in cingulate gyrus epilepsy.Frontiers in neurologyArticle
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Epilepsy is a common brain network disorder associated with disrupted large-scale excitatory and inhibitory neural interactions. Recent resting-state fMRI evidence indicates that global signal (GS) fluctuations that have commonly been ignored are linked to neural activity. However, the mechanisms underlying the altered global pattern of fMRI spontaneous fluctuations in epilepsy remain unclear. Here, we quantified GS topography using beta weights obtained from a multiple regression model in a large group of epilepsy with different subtypes (98 focal temporal epilepsy; 116 generalized epilepsy) and healthy population (n = 151). We revealed that the nonuniformly distributed GS topography across association and sensory areas in healthy controls was significantly shifted in patients. Particularly, such shifts of GS topography disturbances were more widespread and bilaterally distributed in the midbrain, cerebellum, visual cortex, and medial and orbital cortex in generalized epilepsy, whereas in focal temporal epilepsy, these networks spread beyond the temporal areas but mainly remain lateralized. Moreover, we found that these abnormal GS topography patterns were likely to evolve over the course of a longer epilepsy disease. Our study demonstrates that epileptic processes can potentially affect global excitation/inhibition balance and shift the normal GS topological distribution. These progressive topographical GS disturbances in subcortical-cortical networks may underlie pathophysiological mechanisms of global fluctuations in human epilepsy.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.