Trial reportNeurosurgery2021
Survival, Dependency, and Health-Related Quality of Life in Patients With Ruptured Intracranial Aneurysm: 10-Year Follow-up of the United Kingdom Cohort of the International Subarachnoid Aneurysm Trial.
Trial report in Neurosurgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 32 citations in OpenAlex.
- Advances in Microsurgical Clipping for Intracranial Aneurysms: A Narrative Review of Intraoperative Technologies and Clinical Outcomes.Asian journal of neurosurgery · 2026Review
- Increased Antidepressant Use after Intensive Care for Aneurysmal Subarachnoid Haemorrhage: A Machine-Learning-Enhanced Propensity-Matched Nationwide Cohort Study.Neurocritical care · 2026Article
- Long-term quality of life and depressive symptoms among survivors of poor-grade aneurysmal subarachnoid hemorrhage.Brain & spine · 2026Article
- Literature review and DELPHI consensus on follow-up and retreatment of intracranial aneurysms with intrasaccular devices.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2025Article
- Self-assessment of quality of life in patients after suffering from aneurysmal subarachnoid hemorrhage, principal component analysis.Scientific reports · 2025Article
- Factors Influencing the Mortality of Patients with Subarachnoid Haemorrhage in the Intensive Care Unit: A Retrospective Cohort Study.Journal of clinical medicine · 2025Article
- Predicting lower extremity deep venous thrombosis in patients with aneurysmal subarachnoid hemorrhage: a machine learning study.Frontiers in neurology · 2025Article
- One-year survival of aneurysmal subarachnoid hemorrhage after airplane transatlantic transfer - a monocenter retrospective study.BMC anesthesiology · 2024Observational
- ClippingInterventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2024Review
- Evaluation of FRESH scores in predicting outcome and quality of life after aneurysmal subarachnoid haemorrhage in a European patient cohort.Acta neurochirurgica · 2024Article
- Cost-effectiveness of repeat delayed imaging for spontaneous subarachnoid hemorrhage.PloS one · 2023Article
- Endovascular management of intracranial aneurysms at Chris Hani Baragwanath Academic Hospital.SA journal of radiology · 2023Article
- Prognostic nomogram for predicting lower extremity deep venous thrombosis in ruptured intracranial aneurysm patients who underwent endovascular treatment.Frontiers in neurology · 2023Article
- Spontaneous subarachnoid haemorrhage.Lancet (London, England) · 2022Review
- European Stroke Organisation (ESO) guidelines on management of unruptured intracranial aneurysms.European stroke journal · 2022Article
- Microsurgical Management of Posterior Circulation Aneurysms: A Retrospective Study on Epidemiology, Outcomes, and Surgical Approaches.Brain sciences · 2022Article
- Involvement of Microglia in the Pathophysiology of Intracranial Aneurysms and Vascular Malformations-A Short Overview.International journal of molecular sciences · 2021Review
- DCI after Aneurysmal Subarachnoid Hemorrhage Is Related to the Expression of MFG-E8.BioMed research international · 2021Article
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundPrevious analyses of the International Subarachnoid Aneurysm Trial (ISAT) cohort have reported on clinical outcomes after treatment of a ruptured intracranial aneurysm with either neurosurgical clipping or endovascular coiling.
objectiveTo evaluate the long-term quality-adjusted life years (QALYs) gained of endovascular coiling compare to neurosurgical clipping in the UK cohort of ISAT.
methodsBetween September 12, 1994 and May 1, 2002, patients with ruptured intracranial aneurysms who were assumed treatment equipoise were randomly allocated to either neurosurgical clipping or endovascular coiling. We followed-up 1644 patients in 22 UK neurosurgical centers for a minimum of 10 yr. Health-related quality of life (HRQoL) was collected through yearly questionnaires, measured by utilities calculated from the EQ-5D-3L. We compared HRQoL between the 2 treatment groups over a period of 10 yr. In all, 1-yr, 5-yr, and 10-yr QALYs were estimated by combining utility and survival information.
resultsHigher average utility values were found in the endovascular group throughout the follow-up period, with mean differences between groups statistically significant in most years. The 10-yr QALYs were estimated to be 6.68 (95% CI: 6.45-6.90) in the coiling group and 6.32 (95% CI: 6.10-6.55) in the clipping group, respectively, a significant mean difference of 0.36 (95% CI: 0.04-0.66). A third of this mean QALYs gain was estimated to derive solely from HRQoL differences.
conclusionHRQoL after treatment of a ruptured intracranial aneurysm was better after endovascular coiling compared to neurosurgical clipping, which contributed significantly to the QALYs gained over a 10-yr period.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.