Evidence map›Paper›PMID 33073674›Full record

ArticleMolecular pain

Enrichment of genomic pathways based on differential DNA methylation profiles associated with chronic musculoskeletal pain in older adults: An exploratory study.

Soamy Montesino-Goicolea, Puja Sinha, Zhiguang Huo, Asha Rani, Thomas C Foster, Yenisel Cruz-Almeida

Open access · goldAbstract read
In one paragraph

Article in Molecular pain. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Epigenetic Landscapes of Pain: DNA Methylation Dynamics in Chronic Pain.International journal of molecular sciences · 2024
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Soamy Montesino-GoicoleaPain Research & Intervention Center of Excellence, University of Florida, Gainesville, FL, USA.ORCID 0000-0002-0065-0236
Puja SinhaDepartment of Neuroscience, College of Medicine, University of Florida, Gainesville, FL, USA.
Zhiguang HuoDepartment of Biostatistics, College of Public Health & Health Professions and College of Medicine, University of Florida, Gainesville, FL, USA.
Asha RaniDepartment of Neuroscience, College of Medicine, University of Florida, Gainesville, FL, USA.
Thomas C FosterDepartment of Neuroscience, College of Medicine, University of Florida, Gainesville, FL, USA.
Yenisel Cruz-AlmeidaPain Research & Intervention Center of Excellence, University of Florida, Gainesville, FL, USA.ORCID 0000-0002-0065-0236
University of Florida · US

Funding

Supplement-Discovery and Validation of Epigenetic Biomarkers in Brain TissueR01AG067757 · NIA · UNIVERSITY OF FLORIDA · PI CRUZ-ALMEIDA, YENISEL · 2020 to 2024
$4.2M
Estrogen and cognition over the lifespanR01AG037984 · NIA · UNIVERSITY OF FLORIDA · PI FOSTER, THOMAS C, KUMAR, ASHOK · 2011 to 2022
$3.3M
the Integrative and Multidisciplinary Pain and Aging Research Training (IMPART) ProgramT32AG049673 · NIA · UNIVERSITY OF FLORIDA · PI FILLINGIM, ROGER B · 2015 to 2024
$3.2M
Signaling cascades and memory deficits during agingR37AG036800 · NIA · UNIVERSITY OF FLORIDA · PI FOSTER, THOMAS C · 2010 to 2018
$2.6M
Use of viral-vectors for studying effects of chronic inflammation on executive functionR01AG052258 · NIA · UNIVERSITY OF FLORIDA · PI FOSTER, THOMAS C · 2016 to 2020
$1.9M
Mechanisms of Oxytocin's Analgesia in Older Adults (Diversity Supplement)R01AG059809 · NIA · UNIVERSITY OF FLORIDA · PI CRUZ-ALMEIDA, YENISEL, EBNER, NATALIE C · 2018 to 2022
$1.8M
Neuroimaging Age-Related Changes i Pain ModulationK01AG048259 · NIA · UNIVERSITY OF FLORIDA · PI CRUZ-ALMEIDA, YENISEL · 2015 to 2019
$831k
NIA NIH HHS K01 AG048259NIA NIH HHS R01 AG037984NIA NIH HHS R01 AG052258NIA NIH HHS R01 AG059809NIA NIH HHS R01 AG067757NIA NIH HHS R37 AG036800NIA NIH HHS T32 AG049673
6 · The paper itself

Abstract

Our study aimed to identify differentially methylated CpGs/regions and their enriched genomic pathways associated with underlying chronic musculoskeletal pain in older individuals. We recruited cognitively healthy older adults with (

Indexed as

DNA MethylationActivating Transcription Factor 2AgedAntigen PresentationApoptosisChronic PainCpG IslandsFemaleGene Expression RegulationHumansInterleukin-4MaleMusculoskeletal PainOX40 LigandProgrammed Cell Death 1 ReceptorReceptors, GABAActivating Transcription Factor 2ATF2 protein, humanIL4 protein, humanInterleukin-4OX40 LigandPDCD1 protein, humanProgrammed Cell Death 1 ReceptorReceptors, GABATNFSF4 protein, humanChronic musculoskeletal painDNA methylationgamma-aminobutyric acidgenomic pathwaysimmune signalingolder adult

Identifiers

PMID33073674
PMCPMC7711149
OpenAlexW3092948963

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.