ArticleActa ophthalmologica2021
Longitudinal retinal layer changes in preclinical Alzheimer's disease.
Article in Acta ophthalmologica, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 31 citations in OpenAlex.
- Retinal biomarkers for early Alzheimer's detection: a systematic review of optical coherence tomography (OCT) findings.BMJ open ophthalmology · 2026Pooled it
- A systematic survey of advances in retinal imaging modalities for Alzheimer's disease diagnosis.Metabolic brain disease · 2022Pooled it
- Brain and retina in Alzheimer's disease: Pathological intersections and estimates from imaging.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Review
- Ocular changes as potential biomarkers for early diagnosis of Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Review
- Retinal Microstructural and Microvascular Changes in Alzheimer Disease: A Review.International ophthalmology clinics · 2025Review
- Retinal assessment in 143 patients with white matter lesions: the potential of OCTA as an evaluation tool.Frontiers in neurology · 2025Article
- Pathological Mechanisms and Molecular Imaging Advances in Alzheimer's Disease.Clinical interventions in aging · 2025Review
- Progress on early diagnosing Alzheimer's disease.Frontiers of medicine · 2024Review
- Eye Adult Changes in Thought (Eye ACT) Study: Design and Report on the Inaugural Cohort.Journal of Alzheimer's disease : JAD · 2024Article
- Structural and Functional Retinal Changes in Patients with Mild Cognitive Impairment with and without Diabetes.Journal of clinical medicine · 2023Article
- Exploratory Longitudinal Study of Ocular Structural and Visual Functional Changes in Subjects at High Genetic Risk of Developing Alzheimer's Disease.Biomedicines · 2023Article
- Retinal Examination Modalities in the Early Detection of Alzheimer's Disease: Seeing Brain Through the Eye.Journal of translational internal medicine · 2022Article
- Association Between Retinal Layer Thickness and Cognitive Decline in Older Adults.JAMA ophthalmology · 2022Article
- Thicker macula in asymptomaticAlzheimer's & dementia (Amsterdam, Netherlands) · 2022Article
- Changes in retinal multilayer thickness and vascular network of patients with Alzheimer's disease.Biomedical engineering online · 2021Article
- The Value of OCT and OCTA as Potential Biomarkers for Preclinical Alzheimer's Disease: A Review Study.Life (Basel, Switzerland) · 2021Review
- Advances in retina imaging as potential biomarkers for early diagnosis of Alzheimer's disease.Translational neurodegeneration · 2021Review
- Increased choroidal thickness in adults with Down syndrome.Alzheimer's & dementia (Amsterdam, Netherlands) · 2021Article
- Inner and outer retinal abnormalities detected in Alzheimer's disease subjects diagnosed by amyloid PET not revealed when classified based on clinical criteria.Alzheimer's & dementia (Amsterdam, Netherlands)Article
- Retinal imaging biomarkers of Alzheimer's disease: A systematic review and meta-analysis of studies using brain amyloid beta status for case definition.Alzheimer's & dementia (Amsterdam, Netherlands)Review
Corrections and comments
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Authors and funding
13 authors at 3 institutions in 1 country.
Funding
Abstract
purposeSeveral studies found reduced retinal thickness on optical coherence tomography (OCT) in Alzheimer's disease (AD), even in preclinical stages, labelling this technique of interest as biomarker. In this study, we examine retinal thickness changes in preclinical AD, as defined by cognitively normal individuals with amyloid-beta (Aβ) on positron emission tomography (PET).
methodsFor this monocentre study, 145 cognitively healthy monozygotic twins aged ≥ 60 were included from the Netherlands Twin Register taking part in the EMIF-AD PreclinAD study. At baseline, participants underwent [
resultsSixteen participants (11%) were positive for Aβ. Change in retinal thickness did not differ in any region between Aβ+ and Aβ- individuals. A positive association between binding potential and change in inner plexiform layer thickness was observed in the inner macular ring (beta = 1.708, CI = 0.575 to 2.841, p = 0.003).
conclusionAβ+ individuals did not differ in rate of change of any retinal layer compared to controls, but higher binding potential at baseline was associated with less IPL thinning over time. Optical coherence tomography (OCT) as a longitudinal screening tool for preclinical AD seems limited, but IPL changes offer leads for further research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.