ReviewAngewandte Chemie (International ed. in English)2021
Advancing the Logic of Chemical Synthesis: C-H Activation as Strategic and Tactical Disconnections for C-C Bond Construction.
Review in Angewandte Chemie (International ed. in English), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
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Who cites it
58 citing papers in PubMed.
- Total Synthesis of Isoriccardin C and Isoriccardin D Based on a Hydroxyl-Directed Palladium-Catalyzed Intramolecular C-H Alkenylation.Organic letters · 2026Article
- Review
- Enantioselective C-H functionalization: logic and applications in the total synthesis of natural products.Chemical science · 2026Review
- Pd-catalyzed sequential distal C-H alkenylation and π-allylic amination of arylacetic acids using MBH acetates: access to macrocyclic lactams.Chemical science · 2026Article
- Capturing the Hybrid Palladium(I)-Radical Pair Relevant to Photoexcited Palladium Catalysis.Journal of the American Chemical Society · 2025Article
- Total Synthesis of the Nominal Structure of (+)-Talaromyolide D.Journal of the American Chemical Society · 2025Article
- Skeletal editing of 4-arylpyrimidines into diverse nitrogen heteroaromatics via four-atom synthons.Nature communications · 2025Article
- COAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Electro-oxidative amination of benzylic C(sp³)-C(sp³) bonds in aromatic hydrocarbons.Nature communications · 2025Article
- Ir/Ni Metallaphotoredox Catalysis for the C(spChemistry (Weinheim an der Bergstrasse, Germany) · 2025Article
- Asymmetric total synthesis of benzenoid cephalotane-type diterpenoids through a cascade C(spNature communications · 2025Article
- Bis-CFACS catalysis · 2025Article
- Article
- Palladium-Catalyzed Oxidative Allene-Allene Cross-Coupling.Journal of the American Chemical Society · 2025Article
- Article
- Catalyst-controlled directing group translocation in the site selective C-H functionalization of 3-carboxamide indoles and metallocarbenes.Nature communications · 2025Article
- Rapid and scalable ruthenium catalyzed meta-C-H alkylation enabled by resonant acoustic mixing.Communications chemistry · 2024Article
- Total synthesis of (-)-cylindrocyclophane A facilitated by C-H functionalization.Science (New York, N.Y.) · 2024Article
- Deoxygenative radical cross-coupling of C(spNature communications · 2024Article
- Palladium (II)-Catalyzed C-H Activation with Bifunctional Ligands: From Curiosity to Industrialization.Angewandte Chemie (International ed. in English) · 2024Review
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3 authors.
Funding
Abstract
The design of synthetic routes by retrosynthetic logic is decisively influenced by the transformations available. Transition-metal-catalyzed C-H activation has emerged as a powerful strategy for C-C bond formation, with myriad methods developed for diverse substrates and coupling partners. However, its uptake in total synthesis has been tepid, partially due to their apparent synthetic intractability, as well as a lack of comprehensive guidelines for implementation. This Review addresses these issues and offers a guide to identify retrosynthetic opportunities to generate C-C bonds by C-H activation processes. By comparing total syntheses accomplished using traditional approaches and recent C-H activation methods, this Review demonstrates how C-H activation enabled C-C bond construction has led to more efficient retrosynthetic strategies, as well as the execution of previously unattainable tactical maneuvers. Finally, shortcomings of existing processes are highlighted; this Review illustrates how some highlighted total syntheses can be further economized by adopting next-generation ligand-enabled approaches.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.