ArticleAdvanced materials (Deerfield Beach, Fla.)2020
Magneto-Driven Gradients of Diamagnetic Objects for Engineering Complex Tissues.
Article in Advanced materials (Deerfield Beach, Fla.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- 3D Cell Printing and Manipulation with Magnetic Bioinks.Biomedicines · 2026Review
- Evaluating Complexity in Orthopedic Tissue-on-a-Chip Systems.Advanced healthcare materials · 2026Review
- Overview of Magnetic Hydrogel Fabrication, Its Basic Characteristics, and Potential Uses in Biomedical Engineering.Bioengineering (Basel, Switzerland) · 2025Review
- Continuous mechanical-gradient hydrogel with on-demand distributed MnBioactive materials · 2025Article
- Polysaccharide-Based Hydrogels for Advanced Biomedical Engineering Applications.ACS polymers Au · 2024Review
- Physical-property-based patterning: simply engineering complex tissues.Trends in biotechnology · 2024Review
- Natural Polymer-Based Hydrogels: From Polymer to Biomedical Applications.Pharmaceutics · 2023Review
- Magnetic force-based cell manipulation forAPL bioengineering · 2023Review
- Multifunctional silk vinyl sulfone-based hydrogel scaffolds for dynamic material-cell interactions.Biomaterials · 2023Article
- Modeling development using hydrogels.Development (Cambridge, England) · 2023Article
- Linguistic Analysis Identifies Emergent Biomaterial Fabrication Trends for Orthopaedic Applications.Advanced healthcare materials · 2023Review
- Biomimetic natural biomaterials for tissue engineering and regenerative medicine: new biosynthesis methods, recent advances, and emerging applications.Military Medical Research · 2023Review
- Bioengineering Human Cartilage-Bone Tissues for Modeling of Osteoarthritis.Stem cells and development · 2022Article
- Gravity-based patterning of osteogenic factors to preserve bone structure after osteochondral injury in a large animal model.Biofabrication · 2022Article
- Field-Induced Assembly and Propulsion of Colloids.Langmuir : the ACS journal of surfaces and colloids · 2022Article
- Hydrogels for Treatment of Different Degrees of Osteoarthritis.Frontiers in bioengineering and biotechnology · 2022Review
- Fabrication and maturation of integrated biphasic anatomic mesenchymal stromal cell-laden composite scaffolds for osteochondral repair and joint resurfacing.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2021Article
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Authors and funding
6 authors.
Funding
Abstract
Engineering complex tissues represents an extraordinary challenge and, to date, there have been few strategies developed that can easily recapitulate native-like cell and biofactor gradients in 3D materials. This is true despite the fact that mimicry of these gradients may be essential for the functionality of engineered graft tissues. Here, a non-traditional magnetics-based approach is developed to predictably position naturally diamagnetic objects in 3D hydrogels. Rather than magnetizing the objects within the hydrogel, the magnetic susceptibility of the surrounding hydrogel precursor solution is enhanced. In this way, a range of diamagnetic objects (e.g., polystyrene beads, drug delivery microcapsules, and living cells) are patterned in response to a brief exposure to a magnetic field. Upon photo-crosslinking the hydrogel precursor, object positioning is maintained, and the magnetic contrast agent diffuses out of the hydrogel, supporting long-term construct viability. This approach is applied to engineer cartilage constructs with a depth-dependent cellularity mirroring that of native tissue. These are thought to be the first results showing that magnetically unaltered cells can be magneto-patterned in hydrogels and cultured to generate heterogeneous tissues. This work provides a foundation for the formation of opposing magnetic-susceptibility-based gradients within a single continuous material.
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Registered trials
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