Evidence map›Paper›PMID 33073325›Full record

ArticleParasitology research2021

Antitrichomonal activity and docking analysis of thiazole derivatives as TvMP50 protease inhibitors.

Gonzalo Mena-Rejón, Yussel Pérez-Navarro, Julio César Torres-Romero, Laura Vázquez-Carrillo, Rubén M Carballo, Rodrigo Arreola, Ángel Herrera-España, Victor Arana-Argáez, Ramiro Quijano-Quiñones, Jose Manuel Fernández-Sánchez and 1 more

Abstract read
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In one paragraph

Article in Parasitology research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 88% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Gonzalo Mena-RejónFacultad de Química, Universidad Autónoma de Yucatán (UADY), Calle 43 S/N entre calle 96 y calle 40, Colonia Inalámbrica, C.P. 97069, Mérida, Yucatán, México.
Yussel Pérez-NavarroPosgrado en Ciencias Genómicas, Universidad Autónoma de la Ciudad de México (UACM), San Lorenzo # 290, Col. Del Valle, CP 03100, México City, México.
Julio César Torres-RomeroFacultad de Química, Universidad Autónoma de Yucatán (UADY), Calle 43 S/N entre calle 96 y calle 40, Colonia Inalámbrica, C.P. 97069, Mérida, Yucatán, México.
Laura Vázquez-CarrilloPosgrado en Ciencias Genómicas, Universidad Autónoma de la Ciudad de México (UACM), San Lorenzo # 290, Col. Del Valle, CP 03100, México City, México.
Rubén M CarballoFacultad de Química, Universidad Autónoma de Yucatán (UADY), Calle 43 S/N entre calle 96 y calle 40, Colonia Inalámbrica, C.P. 97069, Mérida, Yucatán, México.
Rodrigo ArreolaPsychiatric Genetics Department, Clinical Research Branch, National Institute of Psychiatry, Ramón de la Fuente, Calzada México-Xochimilco 101, Colonia San Lorenzo Huipulco, Tlalpan, 14370, México City, DF, México.
Ángel Herrera-EspañaFacultad de Química, Universidad Autónoma de Yucatán (UADY), Calle 43 S/N entre calle 96 y calle 40, Colonia Inalámbrica, C.P. 97069, Mérida, Yucatán, México.
Victor Arana-ArgáezFacultad de Química, Universidad Autónoma de Yucatán (UADY), Calle 43 S/N entre calle 96 y calle 40, Colonia Inalámbrica, C.P. 97069, Mérida, Yucatán, México.
Ramiro Quijano-QuiñonesFacultad de Química, Universidad Autónoma de Yucatán (UADY), Calle 43 S/N entre calle 96 y calle 40, Colonia Inalámbrica, C.P. 97069, Mérida, Yucatán, México.
Jose Manuel Fernández-SánchezDivisión de Ingeniería en Gestión Empresarial, Tecnológico de Estudios Superiores de Ecatepec, Avenida Tecnológico S/N, Colonia Valle de Anahuac, Ecatepec de Morelos, Estado de México, Mexico.
María Elizbeth Alvarez-SánchezPosgrado en Ciencias Genómicas, Universidad Autónoma de la Ciudad de México (UACM), San Lorenzo # 290, Col. Del Valle, CP 03100, México City, México. elizbeth2@gmail.com.ORCID http://orcid.org/0000-0002-9212-4451
Autonomous University of Yucatán · MXUniversidad Autónoma de la Ciudad de México · MXInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz · MXUniversidad de Ecatepec · MX

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Trichomoniasis, caused by the protozoan Trichomonas vaginalis, is the most prevalent non-viral sexually transmitted infection that affects over 170 million people worldwide. The only type of drug recommended for the therapeutic control of trichomoniasis is the 5-nitroimidazoles, although there have been reports of some undesirable side effects and clinical resistance. Hence, the need for the search for new tricomonicidal agents is necessary. In a previous work, we demonstrated that two 2-amino-4-aryl thiazole derivatives (ATZ-1 and ATZ-2) possess a portent antigiardial effect. In the current paper, we investigated the in vitro antitrichomonal activity of these thiazole compounds. Both ATZ-1 and ATZ-2 reduced the viability and growth of parasites in a dose-dependent manner, with an IC

Indexed as

Antitrichomonal AgentsHumansParasitic Sensitivity TestsProtease InhibitorsThiazolesTrichomonas InfectionsTrichomonas vaginalisAntitrichomonal AgentsATZ1 thiazole derivativeProtease InhibitorsThiazolesAnti-proteolyticThiazoleTrichomoniasisT. vaginalisTvMP50

Identifiers

PMID33073325
OpenAlexW3092661425

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.