Evidence map›Paper›PMID 33073290›Full record

ArticleCerebral cortex (New York, N.Y. : 1991)2021

MEG Theta during Lexico-Semantic and Executive Processing Is Altered in High-Functioning Adolescents with Autism.

Yuqi You, Angeles Correas, R Joanne Jao Keehn, Laura C Wagner, Burke Q Rosen, Lauren E Beaton, Yangfeifei Gao, William T Brocklehurst, Inna Fishman, Ralph-Axel Müller and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cerebral cortex (New York, N.Y. : 1991), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Yuqi YouDepartment of Psychology, San Diego State University, San Diego, CA 92182, USA.
Angeles CorreasDepartment of Psychology, San Diego State University, San Diego, CA 92182, USA.
R Joanne Jao KeehnDepartment of Psychology, San Diego State University, San Diego, CA 92182, USA.
Laura C WagnerDepartment of Psychology, San Diego State University, San Diego, CA 92182, USA.
Burke Q RosenDepartment of Neurosciences, University of California San Diego, San Diego, CA 92093, USA.
Lauren E BeatonDepartment of Psychology, San Diego State University, San Diego, CA 92182, USA.
Yangfeifei GaoDepartment of Psychology, San Diego State University, San Diego, CA 92182, USA.
William T BrocklehurstDepartment of Psychology, San Diego State University, San Diego, CA 92182, USA.
Inna FishmanDepartment of Psychology, San Diego State University, San Diego, CA 92182, USA.
Ralph-Axel MüllerDepartment of Psychology, San Diego State University, San Diego, CA 92182, USA.
Ksenija MarinkovicDepartment of Psychology, San Diego State University, San Diego, CA 92182, USA.
San Diego State University · USUniversity of California San Diego · US

Funding

Integrity and Dynamic Processing Efficiency of Networks in ASDR01MH101173 · NIMH · SAN DIEGO STATE UNIVERSITY · PI MUELLER, RALPH-AXEL · 2014 to 2018
$3.2M
NIMH NIH HHS R01 MH101173
6 · The paper itself

Abstract

Neuroimaging studies have revealed atypical activation during language and executive tasks in individuals with autism spectrum disorders (ASD). However, the spatiotemporal stages of processing associated with these dysfunctions remain poorly understood. Using an anatomically constrained magnetoencephalography approach, we examined event-related theta oscillations during a double-duty lexical decision task that combined demands on lexico-semantic processing and executive functions. Relative to typically developing peers, high-functioning adolescents with ASD had lower performance accuracy on trials engaging selective semantic retrieval and cognitive control. They showed an early overall theta increase in the left fusiform cortex followed by greater activity in the left-lateralized temporal (starting at ~250 ms) and frontal cortical areas (after ~450 ms) known to contribute to language processing. During response preparation and execution, the ASD group exhibited elevated theta in the anterior cingulate cortex, indicative of greater engagement of cognitive control. Simultaneously increased activity in the ipsilateral motor cortex may reflect a less lateralized and suboptimally organized motor circuitry. Spanning early sensory-specific and late response selection stages, the higher event-related theta responsivity in ASD may indicate compensatory recruitment to offset inefficient lexico-semantic retrieval under cognitively demanding conditions. Together, these findings provide further support for atypical language and executive functions in high-functioning ASD.

Indexed as

SemanticsAdolescentAutism Spectrum DisorderCerebral CortexChildExecutive FunctionFemaleHumansMagnetic Resonance ImagingMagnetoencephalographyMalePsychomotor PerformanceReaction TimeTheta RhythmYoung Adultautismcognitive controllanguageMEGTheta oscillations

Identifiers

PMID33073290
PMCPMC7786353
OpenAlexW3093432841

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.