Evidence map›Paper›PMID 33073264›Full record

ArticleJCSM rapid communications

Increased tumour burden alters skeletal muscle properties in the KPC mouse model of pancreatic cancer.

Ravneet Vohra, Matthew D Campbell, Joshua Park, Stella Whang, Kayla Gravelle, Yak-Nam Wang, Joo-Ha Hwang, David J Marcinek, Donghoon Lee

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JCSM rapid communications. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.1field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Exploring heterogeneity: a dive into preclinical models of cancer cachexia.American journal of physiology. Cell physiology · 2024
    Review
  2. Histopathologic Features of Mucosal Head and Neck Cancer Cachexia.International journal of surgical oncology · 2024
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Ravneet VohraDepartment of Radiology, University of Washington, Seattle, USA.
Matthew D CampbellDepartment of Radiology, University of Washington, Seattle, USA.
Joshua ParkDepartment of Radiology, University of Washington, Seattle, USA.
Stella WhangDepartment of Medicine, University of Washington, Seattle, USA.
Kayla GravelleDepartment of Medicine, University of Washington, Seattle, USA.
Yak-Nam WangApplied Physics Laboratory, University of Washington, Seattle, USA.
Joo-Ha HwangDivision of Gastroenterology and Hepatology, Stanford University, Stanford, USA.
David J MarcinekDepartment of Radiology, University of Washington, Seattle, USA.
Donghoon LeeDepartment of Radiology, University of Washington, Seattle, USA.
University of Washington · USStanford University · USUniversity of Washington Applied Physics Laboratory · US

Funding

SPECIFICITY OF OXYGEN DNA DAMAGE AND MUTAGENESISP01AG001751 · NIA · UNIVERSITY OF WASHINGTON · PI PRUSKY, GLEN THOMAS · 1985 to 2021
$29.6M
GENETIC APPROACHES TO AGING RESEARCHT32AG000057 · NIA · UNIVERSITY OF WASHINGTON · PI RABINOVITCH, PETER S · 1985 to 2019
$14.2M
Ultrasound enhanced penetration for treatment of pancreatic cancerR01CA154451 · NCI · UNIVERSITY OF WASHINGTON · PI HWANG, JOO HA · 2011 to 2021
$4.3M
MR-HIFU induced drug delivery for pancreatic cancer treatmentR01CA188654 · NCI · UNIVERSITY OF WASHINGTON · PI LEE, DONGHOON · 2015 to 2019
$2.6M
NCI NIH HHS R01 CA154451NCI NIH HHS R01 CA188654NIA NIH HHS P01 AG001751NIA NIH HHS T32 AG000057
6 · The paper itself

Abstract

backgroundCancer cachexia is a multifactorial wasting syndrome that is characterized by the loss of skeletal muscle mass and weakness, which compromises physical function, reduces quality of life, and ultimately can lead to mortality. Experimental models of cancer cachexia have recapitulated this skeletal muscle atrophy and consequent decline in muscle force generating capacity. We address these issues in a novel transgenic mouse model Kras, Trp53 and Pdx-1-Cre (

methods

resultsIncrease in tumor size resulted in decrease in gastrocnemius maximum cross sectional area, decrease in T

conclusionsOur findings indicate that increase in tumor size may cause alterations in structural and functional parameters of skeletal muscles and that MR parameters may be used as sensitive biomarkers to noninvasively detect structural changes in cachectic muscles.

Indexed as

CachexiaDiffusion tensor imaging (DTI)Magnetic resonance imaging (MRI)Magnetization transfer ratio (MTR)Transverse relaxation time (T2)

Identifiers

PMID33073264
PMCPMC7566781
OpenAlexW3034086842

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.