Evidence map›Paper›PMID 33073190›Full record

ArticleACS pharmacology & translational science2020

Abuse Liability, Anti-Nociceptive, and Discriminative Stimulus Properties of IBNtxA.

Ariful Islam, Mohammad Atiqur Rahman, Megan B Brenner, Allamar Moore, Alyssa Kellmyer, Harley M Buechler, Frank DiGiorgio, Vincent R Verchio, Laura McCracken, Mousumi Sumi and 5 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS pharmacology & translational science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 8 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

Ariful IslamDepartment of Chemistry & Biochemistry and Department of Molecular & Cellular Biosciences, College of Science and Mathematics, Rowan University, 201 Mullica Hill Road, Glassboro, New Jersey 08028, United States.
Mohammad Atiqur RahmanDepartment of Chemistry & Biochemistry and Department of Molecular & Cellular Biosciences, College of Science and Mathematics, Rowan University, 201 Mullica Hill Road, Glassboro, New Jersey 08028, United States.
Megan B BrennerDepartment of Chemistry & Biochemistry and Department of Molecular & Cellular Biosciences, College of Science and Mathematics, Rowan University, 201 Mullica Hill Road, Glassboro, New Jersey 08028, United States.
Allamar MooreDepartment of Chemistry & Biochemistry and Department of Molecular & Cellular Biosciences, College of Science and Mathematics, Rowan University, 201 Mullica Hill Road, Glassboro, New Jersey 08028, United States.
Alyssa KellmyerDepartment of Chemistry & Biochemistry and Department of Molecular & Cellular Biosciences, College of Science and Mathematics, Rowan University, 201 Mullica Hill Road, Glassboro, New Jersey 08028, United States.
Harley M BuechlerDepartment of Chemistry & Biochemistry and Department of Molecular & Cellular Biosciences, College of Science and Mathematics, Rowan University, 201 Mullica Hill Road, Glassboro, New Jersey 08028, United States.
Frank DiGiorgioDepartment of Chemistry & Biochemistry and Department of Molecular & Cellular Biosciences, College of Science and Mathematics, Rowan University, 201 Mullica Hill Road, Glassboro, New Jersey 08028, United States.
Vincent R VerchioDepartment of Chemistry & Biochemistry and Department of Molecular & Cellular Biosciences, College of Science and Mathematics, Rowan University, 201 Mullica Hill Road, Glassboro, New Jersey 08028, United States.
Laura McCrackenDepartment of Chemistry & Biochemistry and Department of Molecular & Cellular Biosciences, College of Science and Mathematics, Rowan University, 201 Mullica Hill Road, Glassboro, New Jersey 08028, United States.
Mousumi SumiDepartment of Chemistry & Biochemistry and Department of Molecular & Cellular Biosciences, College of Science and Mathematics, Rowan University, 201 Mullica Hill Road, Glassboro, New Jersey 08028, United States.
Robert HartleyDepartment of Chemistry & Biochemistry and Department of Molecular & Cellular Biosciences, College of Science and Mathematics, Rowan University, 201 Mullica Hill Road, Glassboro, New Jersey 08028, United States.
Joseph R LizzaDepartment of Chemistry & Biochemistry and Department of Molecular & Cellular Biosciences, College of Science and Mathematics, Rowan University, 201 Mullica Hill Road, Glassboro, New Jersey 08028, United States.
Gustavo Moura-LettsDepartment of Chemistry & Biochemistry and Department of Molecular & Cellular Biosciences, College of Science and Mathematics, Rowan University, 201 Mullica Hill Road, Glassboro, New Jersey 08028, United States.
Bradford D FischerCooper Medical School of Rowan University, 401 Broadway, Camden, New Jersey 08103, United States.
Thomas M KeckDepartment of Chemistry & Biochemistry and Department of Molecular & Cellular Biosciences, College of Science and Mathematics, Rowan University, 201 Mullica Hill Road, Glassboro, New Jersey 08028, United States.
Rowan University · USCooper Medical School of Rowan University · US

Funding

Abuse liability and anti-addiction potential of the atypical mu opioid receptor agonist IBNtxAR03DA041560 · NIDA · ROWAN UNIVERSITY · PI KECK, THOMAS MCGOWAN · 2017 to 2017
$109k
NIDA NIH HHS R03 DA041560
6 · The paper itself

Abstract

IBNtxA (3-iodobenzoyl naltrexamine) is a novel μ-opioid receptor (MOR) agonist which is structurally related to the MOR antagonist naltrexone. Recent studies suggest IBNtxA preferentially signals through truncated MOR splice variants, resulting in anti-nociception with reduced side effects, including no conditioned place preference (CPP) when tested at a single dose. IBNtxA represents an intriguing lead compound for preclinical drug development targeting truncated MOR splice variants, but further evaluation of its

Identifiers

PMID33073190
PMCPMC7551712
OpenAlexW3046044599

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.