Evidence map›Paper›PMID 33073162›Full record

ArticleCurrent developments in nutrition2020

Maternal Diet and the Serum Metabolome in Pregnancy: Robust Dietary Biomarkers Generalizable to a Multiethnic Birth Cohort.

Russell J de Souza, Meera Shanmuganathan, Amel Lamri, Stephanie A Atkinson, Allan Becker, Dipika Desai, Milan Gupta, Piush J Mandhane, Theo J Moraes, Katherine M Morrison and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current developments in nutrition, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
7.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Observational
  4. Article
  5. Article
  6. Plasma Metabolomics of Dietary Intake of Protein-Rich Foods and Kidney Disease Progression in Children.Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation · 2024
    Article
  7. Article
  8. Article
  9. An epidemiological introduction to human metabolomic investigations.Trends in endocrinology and metabolism: TEM · 2023
    Review
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  11. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 8 institutions in 1 country.

Russell J de SouzaDepartment of Health Research Methods, Evidence, and Impact, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada.ORCID 0000-0001-8945-513X
Meera ShanmuganathanDepartment of Chemistry and Chemical Biology, McMaster University, Hamilton, ON, Canada.
Amel LamriPopulation Health Research Institute, Hamilton, ON, Canada.
Stephanie A AtkinsonDepartment of Pediatrics, McMaster University, Hamilton, ON, Canada.
Allan BeckerChildren's Hospital Research Institute, University of Manitoba, Winnipeg, MB, Canada.
Dipika DesaiDepartment of Health Research Methods, Evidence, and Impact, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada.
Milan GuptaDepartment of Medicine, McMaster University, Hamilton, ON, Canada.
Piush J MandhaneDepartment of Pediatrics, University of Alberta, Edmonton, AB, Canada.
Theo J MoraesHospital for Sick Children, Toronto, ON, Canada.
Katherine M MorrisonCentre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, ON, Canada.
Padmaja SubbaraoHospital for Sick Children, Toronto, ON, Canada.
Koon K TeoPopulation Health Research Institute, Hamilton, ON, Canada.
Stuart E TurveyBC Children's Hospital and The University of British Columbia, Vancouver, BC, Canada.
Natalie C WilliamsDepartment of Medicine, McMaster University, Hamilton, ON, Canada.
Philip Britz-McKibbinDepartment of Chemistry and Chemical Biology, McMaster University, Hamilton, ON, Canada.
Sonia S AnandDepartment of Health Research Methods, Evidence, and Impact, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada.
Population Health Research Institute · CAMcMaster University · CACanadian Respiratory Research Network · CAChildren's Hospital Research Institute of Manitoba · CAHospital for Sick Children · CAUniversity of Alberta · CAUniversity of British Columbia · CAUniversity of Toronto · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAdvances in metabolomics are anticipated to decipher associations between dietary exposures and health. Replication biomarker studies in different populations are critical to demonstrate generalizability.

objectivesTo identify and validate robust serum metabolites associated with diet quality and specific foods in a multiethnic cohort of pregnant women.

designIn this cross-sectional analysis of 3 multiethnic Canadian birth cohorts, we collected semiquantitative FFQ and serum data from 900 women at the second trimester of pregnancy. We calculated a diet quality score (DQS), defined as daily servings of "healthy" minus "unhealthy" foods. Serum metabolomics was performed by multisegment injection-capillary electrophoresis-mass spectrometry, and specific serum metabolites associated with maternal DQSs were identified. We combined the results across all 3 cohorts using meta-analysis to classify robust dietary biomarkers (

resultsDiet quality was higher in the South Asian birth cohort (mean DQS = 7.1) than the 2 white Caucasian birth cohorts (mean DQS <3.2). Sixty-six metabolites were detected with high frequency (>75%) and adequate precision (CV <30%), and 47 were common to all cohorts. Hippuric acid was positively associated with healthy diet score in all cohorts, and with the overall DQS only in the primarily white Caucasian cohorts. We observed robust correlations between:

conclusionsSpecific serum metabolites reflect intake of citrus fruit/juice, vegetables, animal foods, and nuts/legumes in pregnant women independent of ethnicity, fasting status, and delays to storage across multiple collection centers. Robust biomarkers of overall diet quality varied by cohort. Proline betaine, 3-methylhistidine, hippuric acid, TMAO, and tryptophan betaine were robust dietary biomarkers for investigations of maternal nutrition in diverse populations.

Indexed as

birth cohortdietdietary biomarkersmetabolomicspregnancyserum

Identifiers

PMID33073162
PMCPMC7547851
OpenAlexW3082422962

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.